| Compound ID |
Compound Name |
Compound Formula |
|
CP0545513
|
(2S)-10-[[5-chloro-2-[(3R,5S)-3-hydroxy-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
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|
C26H29ClF2N6O3
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
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CP0568349
|
N-[(3R,5S)-1-[5-chloro-4-[[(2S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-10-yl]amino]pyrimidin-2-yl]-5-methylpiperidin-3-yl]acetamide
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|
C28H32ClF2N7O3
|
1
|
| 1 |
EC50 = 2.2 nM
|
|
|
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CP0571292
|
(2S)-10-[[5-chloro-2-[(3R)-4,4-difluoro-3-(hydroxymethyl)piperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
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|
C26H27ClF4N6O3
|
1
|
| 1 |
EC50 = 2.7 nM
|
|
|
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CP0543844
|
(2S)-10-[[5-chloro-2-[(3S)-3-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
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|
C26H29ClF2N6O2
|
1
|
| 1 |
EC50 = 6.3 nM
|
|
|
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CP0570246
|
(2S)-10-[[5-chloro-2-[(3S)-4,4-difluoro-3-hydroxypiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
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|
C25H25ClF4N6O3
|
1
|
| 1 |
EC50 = 7.1 nM
|
|
|
|
CP0543758
|
(2S)-10-[[5-chloro-2-[(3R,5S)-3-(dimethylamino)-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
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|
C28H34ClF2N7O2
|
1
|
| 1 |
EC50 = 9.8 nM
|
|
|
|
CP0547237
|
(2S)-10-[[5-chloro-2-[(3R)-3-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
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|
C26H29ClF2N6O2
|
1
|
| 1 |
EC50 = 32.6 nM
|
|
|
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CP0576728
|
5-[[5-chloro-2-[(3R,5S)-3-hydroxy-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-3-(3-hydroxy-3-methylbutyl)-1-methylbenzimidazol-2-one
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|
C23H31ClN6O3
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0260408
|
5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-3-(3-hydroxy-3-methylbutyl)-1-methylbenzimidazol-2-one
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|
C24H31ClF2N6O2
|
1
|
| 1 |
EC50 = 54 nM
|
|
|
|
CP0489925
|
5-[[5-chloro-2-[4,4-difluoro-3-(hydroxymethyl)piperidin-1-yl]pyrimidin-4-yl]amino]-3-(3-hydroxy-3-methylbutyl)-1-methylbenzimidazol-2-one
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|
C23H29ClF2N6O3
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0572795
|
5-[[5-chloro-2-(4,4-difluoro-3-hydroxypiperidin-1-yl)pyrimidin-4-yl]amino]-3-(3-hydroxy-3-methylbutyl)-1-methylbenzimidazol-2-one
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|
C22H27ClF2N6O3
|
1
|
| 1 |
EC50 = 276 nM
|
|
|
|
CP0543843
|
(2S)-10-[[5-chloro-2-[(3S,5R)-3-hydroxy-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
Show/Hide
|
C26H29ClF2N6O3
|
1
|
| 1 |
EC50 > 2000 nM
|
|
|
|
CP0545488
|
(2S)-10-[[5-chloro-2-[(3R,5R)-3-hydroxy-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
Show/Hide
|
C26H29ClF2N6O3
|
1
|
| 1 |
EC50 > 2000 nM
|
|
|
|
CP0568374
|
(2S)-10-[[5-chloro-2-[(3R)-4,4-difluoro-3-hydroxypiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
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|
C25H25ClF4N6O3
|
1
|
| 1 |
EC50 > 2000 nM
|
|
|
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CP0570531
|
N-[(3S,5R)-1-[5-chloro-4-[[(2S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-10-yl]amino]pyrimidin-2-yl]-5-methylpiperidin-3-yl]acetamide
Show/Hide
|
C28H32ClF2N7O3
|
1
|
| 1 |
EC50 > 2000 nM
|
|
|
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CP0570532
|
(2S)-10-[[5-chloro-2-[(3S)-3-hydroxypiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
Show/Hide
|
C25H27ClF2N6O3
|
1
|
| 1 |
EC50 > 2000 nM
|
|
|
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CP0571319
|
(2S)-10-[[5-chloro-2-[(3S,5S)-3-hydroxy-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
Show/Hide
|
C26H29ClF2N6O3
|
1
|
| 1 |
EC50 > 2000 nM
|
|
|
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CP0577099
|
(2S)-10-[[5-chloro-2-[(3S,5R)-3-(dimethylamino)-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
Show/Hide
|
C28H34ClF2N7O2
|
1
|
| 1 |
EC50 > 2000 nM
|
|
|
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CP0577100
|
(2S)-10-[[5-chloro-2-[(3S)-4,4-difluoro-3-(hydroxymethyl)piperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
Show/Hide
|
C26H27ClF4N6O3
|
1
|
| 1 |
EC50 > 2000 nM
|
|
|
|
CP0580074
|
(2S)-10-[[5-chloro-2-[(3R)-3-hydroxypiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
Show/Hide
|
C25H27ClF2N6O3
|
1
|
| 1 |
EC50 > 2000 nM
|
|
|
