Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT03925 , Lysophosphatidic acid receptor 1
Gene Name LPAR1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q92633
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT03925
 
Compound ID Compound Name Compound Formula
CP0477581
3-[1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]pyrrol-3-yl]propanoic acid
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C29H35NO5
 3
1
IC50 = 0.16 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.19 nM
   TI
   LI
   LO
   TS
3
IC50 = 86 nM
   TI
   LI
   LO
   TS
CP0089898
5-chloro-2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]benzoic acid
   Show/Hide
C33H32ClNO6
 1
1
IC50 = 3.5 nM
   TI
   LI
   LO
   TS
CP0576287
(1S,3S)-3-[6-[3-methyl-4-[(2-phenylethylsulfonylamino)methyl]-1,2-oxazol-5-yl]pyridin-3-yl]oxycyclohexane-1-carboxylic acid
   Show/Hide
C25H29N3O6S
 1
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
CP0459357
(1S,3S)-3-[6-[4-[[(3-fluorophenyl)methoxycarbonylamino]methyl]-3-methyl-1,2-oxazol-5-yl]pyridin-3-yl]oxycyclohexane-1-carboxylic acid
   Show/Hide
C25H26FN3O6
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0543033
4-chloro-2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]benzoic acid
   Show/Hide
C33H32ClNO6
 1
1
IC50 = 5.9 nM
   TI
   LI
   LO
   TS
CP0952861
(R)-2-((2-(2-fluoro-4-methoxyphenyl)-2-hydroxy-N-(3-phenylpropyl)acetamido)methyl)-5-methyl-N-(methylsulfonyl)thiazole-4-carboxamide
   Show/Hide
C25H28FN3O6S2
 1
1
IC50 = 6.6 nM
   TI
   LI
   LO
   TS
CP0558533
(1S,3S)-3-[6-[4-[[(4-fluorophenyl)methoxycarbonylamino]methyl]-3-methyl-1,2-oxazol-5-yl]pyridin-3-yl]oxycyclohexane-1-carboxylic acid
   Show/Hide
C25H26FN3O6
 1
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
CP0384713
2-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-phenylpentyl]pyrrol-3-yl]acetic acid
   Show/Hide
C27H33NO5
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0530979
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]-4-methylbenzoic acid
   Show/Hide
C34H35NO6
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0855804
(R)-2-(4'-(4-((1-(2-chlorophenyl)ethoxy)carbonylamino)-3-methylisoxazol-5-yl)biphenyl-4-yl)acetic acid
   Show/Hide
C27H23ClN2O5
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0431765
3-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-phenylpentyl]pyrrol-3-yl]propanoic acid
   Show/Hide
C28H35NO5
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0477577
2-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-thiophen-3-ylpentyl]pyrrol-3-yl]acetic acid
   Show/Hide
C25H31NO5S
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0148963
2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid
   Show/Hide
C27H24N2O5
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0562327
(1S,3S)-3-[6-[4-[[(3,5-difluorophenyl)methoxycarbonylamino]methyl]-3-methyl-1,2-oxazol-5-yl]pyridin-3-yl]oxycyclohexane-1-carboxylic acid
   Show/Hide
C25H25F2N3O6
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0567433
2-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-thiophen-2-ylpentyl]pyrrol-3-yl]acetic acid
   Show/Hide
C25H31NO5S
 1
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
CP0561828
2-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-phenylpentyl]pyrazol-4-yl]acetic acid
   Show/Hide
C26H32N2O5
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0536861
2-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-phenylpentyl]pyrazol-3-yl]acetic acid
   Show/Hide
C26H32N2O5
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0567261
3-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-phenylpentyl]pyrazol-4-yl]propanoic acid
   Show/Hide
C27H34N2O5
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0561827
3-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-thiophen-3-ylpentyl]pyrrol-3-yl]propanoic acid
   Show/Hide
C26H33NO5S
 1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
CP0477578
3-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-phenylpentyl]pyrazol-3-yl]propanoic acid
   Show/Hide
C27H34N2O5
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0445816
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]-5-methylbenzoic acid
   Show/Hide
C34H35NO6
 1
1
IC50 = 42 nM
   TI
   LI
   LO
   TS
CP0431764
3-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-thiophen-2-ylpentyl]pyrrol-3-yl]propanoic acid
   Show/Hide
C26H33NO5S
 1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CP0861029
(R)-2-(4'-(4-((1-(2-chlorophenyl)ethoxy)carbonylamino)-3-methylisothiazol-5-yl)biphenyl-4-yl)acetic acid
   Show/Hide
C27H23ClN2O4S
 1
1
IC50 < 50 nM
   TI
   LI
   LO
   TS
CP0477576
2-[1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]pyrrol-3-yl]acetic acid
   Show/Hide
C28H33NO5
 1
1
IC50 = 61 nM
   TI
   LI
   LO
   TS
CP0477579
2-[4-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-phenylpentyl]phenyl]acetic acid
   Show/Hide
C29H34O5
 1
1
IC50 = 61 nM
   TI
   LI
   LO
   TS
CP0477605
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]benzoic acid
   Show/Hide
C33H33NO6
 1
1
IC50 = 71 nM
   TI
   LI
   LO
   TS
CP0422336
2-[4-[[(3,5-dimethoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]benzoic acid
   Show/Hide
C32H31NO6
 1
1
IC50 = 89 nM
   TI
   LI
   LO
   TS
CP0248077
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]acetic acid
   Show/Hide
C28H31NO6
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0551370
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]-6-methylbenzoic acid
   Show/Hide
C34H35NO6
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0567434
1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-phenylpentyl]pyrrole-3-carboxylic acid
   Show/Hide
C26H31NO5
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0465057
2-[4-[[3-phenylpropyl-(3,4,5-trimethoxybenzoyl)amino]methyl]phenoxy]benzoic acid
   Show/Hide
C33H33NO7
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0481815
3-[4-[[(3,5-dimethoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]benzoic acid
   Show/Hide
C32H31NO6
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0569670
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]-3-methylbenzoic acid
   Show/Hide
C34H35NO6
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0248075
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]acetic acid
   Show/Hide
C28H31NO5
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0511839
2-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-phenylpentyl]imidazol-4-yl]acetic acid
   Show/Hide
C26H32N2O5
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0507011
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-[3-(3-fluorophenyl)propyl]amino]methyl]phenyl]acetic acid
   Show/Hide
C28H30FNO5
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0445697
2-[2-[4-[[(3,5-dimethoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]phenyl]acetic acid
   Show/Hide
C33H33NO5
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0530977
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-[3-(2-fluorophenyl)propyl]amino]methyl]phenyl]acetic acid
   Show/Hide
C28H30FNO5
 1
1
IC50 = 220 nM
   TI
   LI
   LO
   TS
CP0575347
(1S,3S)-3-[4-[4-[[(4-chlorophenyl)methoxycarbonylamino]methyl]-3-methyl-1,2-oxazol-5-yl]phenoxy]cyclohexane-1-carboxylic acid
   Show/Hide
C26H27ClN2O6
 1
1
IC50 = 227 nM
   TI
   LI
   LO
   TS
CP0511815
3-[2-[4-[[(3,5-dimethoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]phenyl]propanoic acid
   Show/Hide
C34H35NO5
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0477628
2-[4-[[(3,5-dimethoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]benzoic acid
   Show/Hide
C32H31NO5
 1
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
CP0530873
2-[4-[[(3,5-dimethylbenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]benzoic acid
   Show/Hide
C32H31NO3
 1
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
CP0450341
2-[4-[[3-phenylpropyl-(3,4,5-trimethoxybenzoyl)amino]methyl]phenyl]benzoic acid
   Show/Hide
C33H33NO6
 1
1
IC50 = 390 nM
   TI
   LI
   LO
   TS
CP0511840
2-[4-[2-(3,5-dimethoxy-4-methylbenzoyl)-5-phenylpentyl]phenyl]acetic acid
   Show/Hide
C29H32O5
 1
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
CP0489959
2-[1-[(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)-hydroxymethyl]-5-phenylpentyl]-3,5-dimethylpyrazol-4-yl]acetic acid
   Show/Hide
C28H36N2O5
 1
1
IC50 = 520 nM
   TI
   LI
   LO
   TS
CP0558532
(1S,3S)-3-[6-[4-[(benzylsulfonylamino)methyl]-3-methyl-1,2-oxazol-5-yl]-2-methylpyridin-3-yl]oxycyclohexane-1-carboxylic acid
   Show/Hide
C25H29N3O6S
 1
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
CP0555797
3-[3-[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]propoxy]benzoic acid
   Show/Hide
C29H33NO6
 1
1
IC50 = 680 nM
   TI
   LI
   LO
   TS
CP0567605
2-[4-[[(3-methoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]benzoic acid
   Show/Hide
C31H29NO4
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0530978
2-[4-[[(3-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]benzoic acid
   Show/Hide
C31H29NO3
 1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0465056
2-[4-[[(2-methoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]benzoic acid
   Show/Hide
C31H29NO4
 1
1
IC50 = 3300 nM
   TI
   LI
   LO
   TS
CP0445696
2-[4-[[(3,4-dimethoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]benzoic acid
   Show/Hide
C32H31NO5
 1
1
IC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0511814
2-[4-[[(4-methoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]benzoic acid
   Show/Hide
C31H29NO4
 1
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS
CP0566615
2-[4-[[(3-fluorobenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]benzoic acid
   Show/Hide
C30H26FNO3
 1
1
IC50 = 5500 nM
   TI
   LI
   LO
   TS
CP0455953
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(4-phenylbutyl)amino]methyl]phenoxy]acetic acid
   Show/Hide
C29H33NO6
 1
1
IC50 = 6600 nM
   TI
   LI
   LO
   TS
CP0567604
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(2-phenylethyl)amino]methyl]phenoxy]acetic acid
   Show/Hide
C27H29NO6
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0445695
2-[4-[[benzoyl(3-phenylpropyl)amino]methyl]phenyl]benzoic acid
   Show/Hide
C30H27NO3
 1
1
IC50 = 12100 nM
   TI
   LI
   LO
   TS
CP0387271
4-(2-ethylbutyl)-N-[3-(4-fluorophenoxy)-5-pyridin-4-yloxyphenyl]-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C29H34FN3O4
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0398647
N-[3,5-bis(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C30H34F2N2O4
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0398735
N-[3-(4-cyanophenoxy)-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C31H34FN3O4
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0411434
4-(2-ethylbutyl)-N-[3-(4-fluorophenoxy)-5-pyridin-2-yloxyphenyl]-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C29H34FN3O4
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0477277
4-(2-ethylbutyl)-N-[3-(4-fluorophenoxy)-5-pyridin-3-yloxyphenyl]-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C29H34FN3O4
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0355224
4-(2-ethylbutyl)-N-[3-(4-fluorophenoxy)-5-[4-(methylcarbamoyl)phenoxy]phenyl]-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C32H38FN3O5
 1
1
IC50 > 800 nM
   TI
   LI
   LO
   TS
CP0375037
N-[3-(4-carbamoylphenoxy)-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C31H36FN3O5
 1
1
IC50 > 800 nM
   TI
   LI
   LO
   TS
CP0379497
4-(2-ethylbutyl)-N-[3-(4-fluorophenoxy)-5-(4-sulfamoylphenoxy)phenyl]-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C30H36FN3O6S
 1
1
IC50 > 800 nM
   TI
   LI
   LO
   TS
CP0387270
N-[3-(3-carbamoylphenoxy)-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C31H36FN3O5
 1
1
IC50 > 800 nM
   TI
   LI
   LO
   TS
CP0388589
N-[3-[4-(dimethylcarbamoyl)phenoxy]-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C33H40FN3O5
 1
1
IC50 > 800 nM
   TI
   LI
   LO
   TS
CP0398734
N-[3-(2-carbamoylphenoxy)-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C31H36FN3O5
 1
1
IC50 > 800 nM
   TI
   LI
   LO
   TS
CP0411436
4-(2-ethylbutyl)-N-[3-(4-fluorophenoxy)-5-(4-methylsulfonylphenoxy)phenyl]-4-hydroxypiperidine-1-carboxamide
   Show/Hide
C31H37FN2O6S
 1
1
IC50 > 800 nM
   TI
   LI
   LO
   TS
CP0445815
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-[3-(4-fluorophenyl)propyl]amino]methyl]phenyl]acetic acid
   Show/Hide
C28H30FNO5
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0477580
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-[(E)-3-phenylprop-2-enyl]amino]methyl]phenyl]acetic acid
   Show/Hide
C28H29NO5
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0567606
4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]benzoic acid
   Show/Hide
C27H29NO5
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0905898
3-[1-[(2S,3S)-3-(3,5-dimethoxy-4-methyl-phenyl)-3-hydroxy-2-(indan-2-ylmethyl)propyl]pyrrol-3-yl]-2,3-ditritio-propanoic acid
   Show/Hide
C29H35NO5
 6
1
Kd = 0.34 nM
   TI
   LI
   LO
   TS
2
Kd = 0.49 nM
   TI
   LI
   LO
   TS
3
Kd = 0.74 nM
   TI
   LI
   LO
   TS
4
Kd = 1.26 nM
   TI
   LI
   LO
   TS
5
Kd = 2.34 nM
   TI
   LI
   LO
   TS
6
Kd = 22.5 nM
   TI
   LI
   LO
   TS
CP0867590
2-[4-[[(3,5-dimethoxy-4-methyl-benzoyl)-(3-phenyl-2,3-ditritio-propyl)amino]methyl]phenyl]acetic acid
   Show/Hide
C28H31NO5
 4
1
Kd = 5.96 nM
   TI
   LI
   LO
   TS
2
Kd = 6.54 nM
   TI
   LI
   LO
   TS
3
Kd = 8.12 nM
   TI
   LI
   LO
   TS
4
Kd = 10.2 nM
   TI
   LI
   LO
   TS