Brief Information of the Cell Line and Protein
Cell Line ID: CL000702 , THP1-ASC-GFP
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_A8AT
Protein ID: PT03614 , NACHT, LRR and PYD domains-containing protein 3
Gene Name NLRP3
Organism Homo sapiens, Human
Protein Classification Unclassified protein
Uniprot ID Q96P20
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000702  Protein ID: PT03614
 
Compound ID Compound Name Compound Formula
CP0577087
2-(1,2,3,5,6,7-hexahydro-s-indacen-4-ylamino)-5-(pyridin-2-ylmethyl)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-7-thione
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C23H22N6S
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0543672
1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[[(6S)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl]sulfonyl]urea
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C20H25N5O4S
 1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0578401
2-(1,2,3,5,6,7-hexahydro-s-indacen-4-ylamino)-5-(oxan-2-ylmethyl)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-7-thione
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C23H27N5OS
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0551749
2-(1,2,3,5,6,7-hexahydro-s-indacen-4-ylamino)-5-(pyridin-2-ylmethyl)-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
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C23H22N6O
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0546714
2-(1,2,3,5,6,7-hexahydro-s-indacen-4-ylamino)-5-(oxan-2-ylmethyl)-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
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C23H27N5O2
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS