Brief Information of the Compound and Protein
Compound Name
2-(1,2,3,5,6,7-hexahydro-s-indacen-4-ylamino)-5-(pyridin-2-ylmethyl)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-7-thione
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PubChem ID
CID: 164946940
Canonical SMILES
S=c1cc(Cc2ccccn2)[nH]c2nc(Nc3c4CCCc4cc4CCCc34)nn12
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Compound Formula C23H22N6S
Compound Structure
Protein Name
NACHT, LRR and PYD domains-containing protein 3
Protein Classification
Unclassified protein
Uniprot ID
Q96P20
Gene Name
NLRP3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000752 PBMC iPSC #1 Homo sapiens (Human)  1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CL000702 THP1-ASC-GFP Homo sapiens (Human)  1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS