Brief Information of the Cell Line and Protein
Cell Line ID: CL000026 , CHO-K1
Synonyms
CHO K1
CHOK1
CHO cell clone K1
GM15452
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0214
Protein ID: PT02509 , G-protein coupled bile acid receptor 1
Gene Name GPBAR1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q8TDU6
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000026  Protein ID: PT02509
 
Compound ID Compound Name Compound Formula
CP0204869
5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)-2-[2-(4-imidazol-1-ylphenoxy)ethylsulfanyl]imidazole
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C31H31FN4O3S
 1
1
EC50 = 0.057 nM
   TI
   LI
   LO
   TS
CP0510886
5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)-2-[2-[4-(2-methylimidazol-1-yl)phenoxy]ethylsulfanyl]imidazole
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C32H33FN4O3S
 1
1
EC50 = 1.48 nM
   TI
   LI
   LO
   TS
CP0553637
2-[2-[(2-chloro-6-fluorophenyl)methoxy]ethylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole
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C29H29ClF2N2O3S
 1
1
EC50 = 1.6 nM
   TI
   LI
   LO
   TS
CP0459488
4-[2-[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylethoxy]benzonitrile
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C29H28FN3O3S
 1
1
EC50 = 2.3 nM
   TI
   LI
   LO
   TS
CP0480938
4-[2-[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylethoxymethyl]benzonitrile
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C30H30FN3O3S
 1
1
EC50 = 2.3 nM
   TI
   LI
   LO
   TS
CP0420118
5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-2-[2-(2-fluoro-4-imidazol-1-ylphenoxy)ethylsulfanyl]-1-(4-fluorophenyl)imidazole
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C31H30F2N4O3S
 1
1
EC50 = 5.8 nM
   TI
   LI
   LO
   TS
CP0509843
5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)-2-[2-(4-pyrrol-1-ylphenoxy)ethylsulfanyl]imidazole
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C32H32FN3O3S
 1
1
EC50 = 7.8 nM
   TI
   LI
   LO
   TS
CP0508991
5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-2-[2-[2-fluoro-4-(2-methylimidazol-1-yl)phenoxy]ethylsulfanyl]-1-(4-fluorophenyl)imidazole
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C32H32F2N4O3S
 1
1
EC50 = 8.6 nM
   TI
   LI
   LO
   TS
CP0533333
2-[2-[(2,6-difluorophenyl)methoxy]ethylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole
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C29H29F3N2O3S
 1
1
EC50 = 14.4 nM
   TI
   LI
   LO
   TS
CP0508992
1-[4-[2-[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylethoxy]phenyl]-1,2,4-triazole
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C30H30FN5O3S
 1
1
EC50 = 16.8 nM
   TI
   LI
   LO
   TS
CP0508993
2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole
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C27H25ClF2N2O2S
 1
1
EC50 = 17.08 nM
   TI
   LI
   LO
   TS
CP0567164
2-[2-[(3-chlorophenyl)methoxy]ethylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole
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C29H30ClFN2O3S
 1
1
EC50 = 17.2 nM
   TI
   LI
   LO
   TS
CP0443438
5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)-2-[2-(4-pyrazol-1-ylphenoxy)ethylsulfanyl]imidazole
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C31H31FN4O3S
 1
1
EC50 = 19.6 nM
   TI
   LI
   LO
   TS
CP0412480
3-[2-[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylethoxymethyl]benzonitrile
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C30H30FN3O3S
 1
1
EC50 = 21.6 nM
   TI
   LI
   LO
   TS
CP0572671
2-[4-[2-[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylethoxy]phenyl]-1,3-thiazole
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C31H30FN3O3S2
 1
1
EC50 = 31.5 nM
   TI
   LI
   LO
   TS
CP0570437
2-[2-[(2-chloro-6-fluorophenyl)methoxy]ethylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole
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C27H23Cl3F2N2OS
 1
1
EC50 = 35.7 nM
   TI
   LI
   LO
   TS
CP0574182
5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)-2-(2-phenoxyethylsulfanyl)imidazole
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C28H29FN2O3S
 1
1
EC50 = 38 nM
   TI
   LI
   LO
   TS
CP0520042
4-[2-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylethoxymethyl]benzonitrile
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C28H24Cl2FN3OS
 1
1
EC50 = 67.5 nM
   TI
   LI
   LO
   TS
CP0567165
4-[2-[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfonylethoxymethyl]benzonitrile
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C30H30FN3O5S
 1
1
EC50 = 94.7 nM
   TI
   LI
   LO
   TS
CP0420117
5-[2-[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylethoxy]-1H-indole
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C30H30FN3O3S
 1
1
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0504964
5-[2-[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylethoxy]-1H-indazole
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C29H29FN4O3S
 1
1
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0533331
5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)-2-[2-[[4-(oxolan-3-yl)phenyl]methoxy]ethylsulfanyl]imidazole
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C33H37FN2O4S
 1
1
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0567163
5-[4-[2-[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylethoxymethyl]phenyl]-2H-tetrazole
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C30H31FN6O3S
 1
1
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0533332
5-[4-[2-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylethoxymethyl]phenyl]-2H-tetrazole
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C28H25Cl2FN6OS
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0561294
4-[2-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfonylethoxymethyl]benzonitrile
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C28H24Cl2FN3O3S
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS