| Compound ID |
Compound Name |
Compound Formula |
|
CP0702276
|
(R)-3-(4-(aminomethyl)phenyl)-6-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one trifluoroacetic acid salt
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C31H35F3N6O5
|
1
|
| 1 |
IC50 = 19.7 nM
|
|
|
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CP0322777
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methyl 4-[[4-[[3-[4-(aminomethyl)phenyl]-2-methyl-7-oxopyrazolo[4,3-d]pyrimidin-6-yl]methyl]-4-hydroxypiperidin-1-yl]methyl]-3-chlorobenzoate;2,2,2-trifluoroacetic acid
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C32H33ClF6N6O8
|
1
|
| 1 |
IC50 = 40.8 nM
|
|
|
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CP0553771
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methyl 4-[4-[[3-[4-(acetamidomethyl)phenyl]-2-methyl-7-oxopyrazolo[4,3-d]pyrimidin-6-yl]methyl]-4-hydroxypiperidin-1-yl]-3-chlorobenzoate
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|
C29H31ClN6O5
|
1
|
| 1 |
IC50 = 121.3 nM
|
|
|
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CP0565073
|
methyl 4-[4-[(3-bromo-2-methyl-7-oxopyrazolo[4,3-d]pyrimidin-6-yl)methyl]-4-hydroxypiperidin-1-yl]-3-chlorobenzoate
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|
C20H21BrClN5O4
|
1
|
| 1 |
IC50 = 156.6 nM
|
|
|
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CP0557134
|
methyl 3-chloro-4-[4-hydroxy-4-[[2-methyl-3-[4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]phenyl]-7-oxopyrazolo[4,3-d]pyrimidin-6-yl]methyl]piperidin-1-yl]benzoate
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|
C32H37ClN6O6
|
1
|
| 1 |
IC50 = 208.8 nM
|
|
|
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CP0532328
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methyl 3-fluoro-4-[[4-[[1-(4-fluorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]methyl]-4-hydroxypiperidin-1-yl]methyl]benzoate
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|
C26H25F2N5O4
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
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CP0553770
|
methyl 3-chloro-4-[[4-[[1-(4-fluorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]methyl]-4-hydroxypiperidin-1-yl]methyl]benzoate
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|
C26H25ClFN5O4
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
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CP0570288
|
methyl 3-bromo-4-[[4-[[1-(4-fluorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]methyl]-4-hydroxypiperidin-1-yl]methyl]benzoate
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|
C26H25BrFN5O4
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
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CP0507608
|
5-[[1-[(2-chloro-4-fluorophenyl)methyl]-4-hydroxypiperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
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|
C24H22ClF2N5O2
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
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CP0568145
|
5-[[1-[(4-bromo-2-chlorophenyl)methyl]-4-hydroxypiperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
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|
C24H22BrClFN5O2
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
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CP0573056
|
5-[[1-[(2-bromophenyl)methyl]-4-hydroxypiperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
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|
C24H23BrFN5O2
|
1
|
| 1 |
IC50 = 3100 nM
|
|
|
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CP0507609
|
5-[[1-[(2,4-dichlorophenyl)methyl]-4-hydroxypiperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
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|
C24H22Cl2FN5O2
|
1
|
| 1 |
IC50 = 3300 nM
|
|
|
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CP0552704
|
5-[[1-[(2-chlorophenyl)methyl]-4-hydroxypiperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
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|
C24H23ClFN5O2
|
1
|
| 1 |
IC50 = 3400 nM
|
|
|
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CP0551759
|
methyl 4-[[4-[[1-(4-fluorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]methyl]-4-hydroxypiperidin-1-yl]methyl]benzoate
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|
C26H26FN5O4
|
1
|
| 1 |
IC50 = 4500 nM
|
|
|
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CP0558440
|
5-[[1-[(4-bromophenyl)methyl]-4-hydroxypiperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
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|
C24H23BrFN5O2
|
1
|
| 1 |
IC50 = 6700 nM
|
|
|
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CP0534591
|
5-[[1-[(4-chlorophenyl)methyl]-4-hydroxypiperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
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|
C24H23ClFN5O2
|
1
|
| 1 |
IC50 = 8000 nM
|
|
|
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CP0424988
|
2-[[4-[[1-(4-fluorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]methyl]-4-hydroxypiperidin-1-yl]methyl]benzonitrile
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|
C25H23FN6O2
|
1
|
| 1 |
IC50 = 8100 nM
|
|
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CP0571938
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1-(4-fluorophenyl)-5-[[4-hydroxy-1-[(4-nitrophenyl)methyl]piperidin-4-yl]methyl]pyrazolo[3,4-d]pyrimidin-4-one
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|
C24H23FN6O4
|
1
|
| 1 |
IC50 = 9000 nM
|
|
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CP0507611
|
1-(4-fluorophenyl)-5-[[1-[(2-fluorophenyl)methyl]-4-hydroxypiperidin-4-yl]methyl]pyrazolo[3,4-d]pyrimidin-4-one
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|
C24H23F2N5O2
|
1
|
| 1 |
IC50 = 9800 nM
|
|
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CP0557135
|
5-chloro-2-[[4-[[1-(4-fluorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]methyl]-4-hydroxypiperidin-1-yl]methyl]benzonitrile
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|
C25H22ClFN6O2
|
1
|
| 1 |
IC50 = 11400 nM
|
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