| Compound ID |
Compound Name |
Compound Formula |
|
CP0917216
|
(1S,5S)-8-(butylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
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|
C22H30N4O4S
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0453350
|
(1-methylcyclopropyl) 9-[6-(2-chloro-4-cyanoanilino)-5-methylpyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
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|
C24H26ClN5O4
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0259933
|
tert-butyl (3R)-4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
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|
C21H26N6O3
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0376173
|
(1-methylcyclopropyl) 9-[6-(2-chloro-4-cyanoanilino)-5-methoxypyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
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|
C24H26ClN5O5
|
1
|
| 1 |
EC50 = 43 nM
|
|
|
|
CP0450357
|
(1-methylcyclopropyl) 9-[6-(4-cyano-2-fluoroanilino)-5-methoxypyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
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|
C24H26FN5O5
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0025099
|
4-[[2-[(2R)-2-methyl-4-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)piperazin-1-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile
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|
C21H24N8O2
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
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CP0917214
|
(1R,5R)-isopropyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]oct-6-ene-8-carboxylate
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|
C22H26N4O4
|
1
|
| 1 |
EC50 = 52 nM
|
|
|
|
CP0922343
|
(1S,5S)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-(propylsulfonyl)-8-azabicyclo[3.2.1]octane
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|
C21H28N4O4S
|
1
|
| 1 |
EC50 = 53 nM
|
|
|
|
CP0895062
|
(1S,5S)-isopropyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C22H28N4O4
|
1
|
| 1 |
EC50 = 55 nM
|
|
|
|
CP0915408
|
(1S,5S)-1-cyclopropylethyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
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|
C24H30N4O4
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0895065
|
(1S,5S)-8-(cyclopropylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C21H26N4O4S
|
1
|
| 1 |
EC50 = 63 nM
|
|
|
|
CP0895067
|
2-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-yloxy)benzonitrile
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|
C22H24N4O4S
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0847545
|
(1S,5S)-8-(isobutylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C22H30N4O4S
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0915403
|
(1S,5S)-3-(6-(2-chlorophenoxy)-5-methylpyrimidin-4-yloxy)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octane
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|
C21H24ClN3O4S
|
1
|
| 1 |
EC50 = 82 nM
|
|
|
|
CP0881291
|
(R)-4-((2-(2-methyl-4-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)piperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
|
C22H24N8O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0460295
|
(1-methylcyclopropyl) 9-[6-(2-chloro-4-cyanophenoxy)-5-methylpyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
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|
C24H25ClN4O5
|
1
|
| 1 |
EC50 = 128 nM
|
|
|
|
CP0654582
|
3-chloro-4-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-ylamino)benzonitrile
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|
C22H24ClN5O3S
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0895066
|
(1S,5S)-8-(5-chlorothiophen-2-ylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
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|
C22H23ClN4O4S2
|
1
|
| 1 |
EC50 = 145 nM
|
|
|
|
CP0690692
|
(R)-3-(trifluoromethyl)oxetan-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C21H21F3N6O4
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0868802
|
4-((2-((R)-4-(5-((S)-1-methoxyethyl)-1,2,4-oxadiazol-3-yl)-2-methylpiperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
|
C21H24N8O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0893051
|
4-((2-((R)-4-(5-((R)-1-methoxyethyl)-1,2,4-oxadiazol-3-yl)-2-methylpiperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
|
C21H24N8O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0893106
|
(3R)-3-(trifluoromethyl)tetrahydrofuran-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C22H23F3N6O4
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0847548
|
2-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-ylamino)benzonitrile
Show/Hide
|
C22H25N5O3S
|
1
|
| 1 |
EC50 = 180 nM
|
|
|
|
CP0453358
|
tert-butyl 7-[6-(2-chloro-4-methylsulfonylanilino)-5-methylpyrimidin-4-yl]oxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate
Show/Hide
|
C24H31ClN4O6S
|
1
|
| 1 |
EC50 = 190 nM
|
|
|
|
CP0377829
|
(1R,3S,5R)-8-(cyclopropylsulfonyl)-6,6-difluoro-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C21H24F2N4O4S
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0895060
|
4-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-ylamino)-3-fluorobenzonitrile
Show/Hide
|
C22H24FN5O3S
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0895061
|
(1R,5R)-8-(cyclopropylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]oct-6-ene
Show/Hide
|
C21H24N4O4S
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0917218
|
(1S,5S)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-(3,3,3-trifluoropropylsulfonyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C21H25F3N4O4S
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0406105
|
(1-methylcyclopropyl) 9-[6-(2-chloro-4-cyanoanilino)pyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C23H24ClN5O4
|
1
|
| 1 |
EC50 = 254 nM
|
|
|
|
CP0895068
|
5-chloro-2-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-yloxy)benzonitrile
Show/Hide
|
C22H23ClN4O4S
|
1
|
| 1 |
EC50 = 290 nM
|
|
|
|
CP0910253
|
(1S,5S)-tert-butyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H30N4O4
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0915400
|
(1S,5S)-ethyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C21H26N4O4
|
1
|
| 1 |
EC50 = 324 nM
|
|
|
|
CP0847546
|
(1S,5S)-8-(4-fluorophenylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C24H25FN4O4S
|
1
|
| 1 |
EC50 = 350 nM
|
|
|
|
CP0121403
|
4-[[2-[(2R)-2-methyl-4-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]piperazin-1-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile
Show/Hide
|
C19H17F3N8O2
|
1
|
| 1 |
EC50 = 398.11 nM
|
|
|
|
CP0498951
|
propan-2-yl 4-[6-(2-fluoro-4-methylsulfonylphenoxy)pyrimidin-4-yl]oxypiperidine-1-carboxylate
Show/Hide
|
C20H24FN3O6S
|
1
|
| 1 |
EC50 = 403 nM
|
|
|
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CP0890135
|
(R)-3-isopropyloxetan-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C23H28N6O4
|
1
|
| 1 |
EC50 = 501.19 nM
|
|
|
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CP0375029
|
(1-methylcyclopropyl) 7-[6-(2-fluoro-4-methylsulfonylanilino)-5-methylpyrimidin-4-yl]oxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate
Show/Hide
|
C24H29FN4O6S
|
1
|
| 1 |
EC50 = 511 nM
|
|
|
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CP0868801
|
4-((2-((2R)-4-(5-(1,4-dioxan-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylpiperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
|
C22H24N8O4
|
1
|
| 1 |
EC50 = 630.96 nM
|
|
|
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CP0890134
|
(R)-4-((2-(4-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylpiperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
|
C21H24N8O3
|
1
|
| 1 |
EC50 = 630.96 nM
|
|
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CP0894309
|
(R)-3-methyloxetan-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C21H24N6O4
|
1
|
| 1 |
EC50 = 630.96 nM
|
|
|
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CP0910358
|
6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-N-(2-fluoro-4-(methylsulfonyl)phenyl)-5-methylpyrimidin-4-amine
Show/Hide
|
C22H27FN4O5S2
|
1
|
| 1 |
EC50 = 640 nM
|
|
|
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CP0847542
|
(1S,5S)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-(2,2,2-trifluoroethylsulfonyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C20H23F3N4O4S
|
1
|
| 1 |
EC50 = 660 nM
|
|
|
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CP0460707
|
(1R,3S,5R)-8-(cyclopropylsulfonyl)-6-fluoro-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C21H25FN4O4S
|
1
|
| 1 |
EC50 = 710 nM
|
|
|
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CP0847543
|
2-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-ylamino)-5-fluorobenzonitrile
Show/Hide
|
C22H24FN5O3S
|
1
|
| 1 |
EC50 = 820 nM
|
|
|
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CP0406104
|
3-chloro-4-[[6-[(7-cyclopropylsulfonyl-3-oxa-7-azabicyclo[3.3.1]nonan-9-yl)oxy]-5-methylpyrimidin-4-yl]amino]benzonitrile
Show/Hide
|
C22H24ClN5O4S
|
1
|
| 1 |
EC50 = 844 nM
|
|
|
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CP0894314
|
(R)-3-ethyloxetan-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C22H26N6O4
|
1
|
| 1 |
EC50 = 1000 nM
|
|
|
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CP0416312
|
3-chloro-4-[[6-[(9-cyclopropylsulfonyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)oxy]-5-methylpyrimidin-4-yl]amino]benzonitrile
Show/Hide
|
C22H24ClN5O4S
|
1
|
| 1 |
EC50 = 1600 nM
|
|
|
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CP0917217
|
6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methyl-N-(2-methylpyridin-3-yl)pyrimidin-4-amine
Show/Hide
|
C21H27N5O3S
|
1
|
| 1 |
EC50 = 2000 nM
|
|
|
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CP0893105
|
(R)-((R)-tetrahydrofuran-3-yl)4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C21H24N6O4
|
1
|
| 1 |
EC50 = 3162.28 nM
|
|
|
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CP0847544
|
(1S,5S)-cyclopropylmethyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H28N4O4
|
1
|
| 1 |
EC50 = 7573 nM
|
|
|
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CP0847541
|
(1S,5S)-2,2,2-trifluoroethyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C21H23F3N4O4
|
1
|
| 1 |
EC50 = 10357 nM
|
|
|
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CP0847540
|
(1S,5S)-1-methylcyclopropyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H28N4O4
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
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CP0893107
|
(R)-oxetan-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C20H22N6O4
|
1
|
| 1 |
EC50 > 31622.78 nM
|
|
|
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CP0949268
|
(R)-((S)-tetrahydrofuran-3-yl)4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C21H24N6O4
|
1
|
| 1 |
EC50 > 1995.26 nM
|
|
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CP0840907
|
(R)-4-((2-(4-(5-isopropyl-1,3,4-oxadiazol-2-yl)-2-methylpiperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
|
C21H24N8O2
|
1
|
| 1 |
EC50 > 3981.07 nM
|
|
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CP0868780
|
(R)-tetrahydro-2H-pyran-4-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C22H26N6O4
|
1
|
| 1 |
EC50 > 7943.28 nM
|
|
|
