Brief Information of the Cell Line and Protein
Cell Line ID: CL001057 , Ptch-deficient MEF
 Cell Line Info 
Category Transformed cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_4240
Protein ID: PT02397 , Protein smoothened
 Protein Info 
Gene Name SMO
Organism Mus musculus, Mouse
Protein Classification Membrane receptor
Uniprot ID P56726
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL001057
 Cell Line Info 
 Protein ID: PT02397
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0136263
 Compound Info 
(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
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C27H41NO2
  2
1
IC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0381132
 Compound Info 
2-[(3R,8E,11S)-3-(4-chlorophenyl)-5,12-dioxo-1-oxa-4-azacyclododec-8-en-11-yl]-N-[(4-chlorophenyl)methyl]acetamide
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C25H26Cl2N2O4
  2
1
IC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 3500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0445334
 Compound Info 
2-[(3R,8E,11S)-3-benzyl-5,12-dioxo-1-oxa-4-azacyclododec-8-en-11-yl]-N-[(4-chlorophenyl)methyl]acetamide
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C26H29ClN2O4
  2
1
IC50 = 8100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 8800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS