Brief Information of the Cell Line and Protein
Cell Line ID: CL000501 , HeLa-MAGI-CCR5
Synonyms
MAGI-CCR5
MAGI-CCR-5
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_D260
Protein ID: PT02059 , C-X-C chemokine receptor type 4
Gene Name CXCR4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P61073
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000501  Protein ID: PT02059
 
Compound ID Compound Name Compound Formula
CP0070322
N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C23H32N4
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0387771
N'-[[(3R)-2-propan-2-yl-3,4-dihydro-1H-isoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C26H38N4
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0387864
N'-[[(3R)-2-methyl-3,4-dihydro-1H-isoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C24H34N4
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0466954
N,N-dimethyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C25H36N4
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0387863
N'-[[(3R)-2-(1,3-oxazol-4-ylmethyl)-3,4-dihydro-1H-isoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C27H35N5O
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0445507
N-propan-2-yl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C26H38N4
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0432257
N'-[[(3R)-2-(pyridin-4-ylmethyl)-3,4-dihydro-1H-isoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C29H37N5
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0444196
N'-[[(3R)-2-(pyridin-2-ylmethyl)-3,4-dihydro-1H-isoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C29H37N5
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0524752
N'-[[(3R)-2-(pyridin-3-ylmethyl)-3,4-dihydro-1H-isoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C29H37N5
 1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CP0392740
2-[(3R)-3-[[4-aminobutyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-1-morpholin-4-ylethanone
   Show/Hide
C29H41N5O2
 1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0489179
N-(pyridin-2-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C29H37N5
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0484544
4-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]butylurea
   Show/Hide
C24H33N5O
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0445508
N'-[[(1R)-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C23H32N4
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0471105
N-[4-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]butyl]acetamide
   Show/Hide
C25H34N4O
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0387865
1,1-dimethyl-3-[4-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]butyl]urea
   Show/Hide
C26H37N5O
 1
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
CP0524974
N'-[[(1S)-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C23H32N4
 1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0524118
N'-[[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
   Show/Hide
C23H32N4
 1
1
IC50 = 1360 nM
   TI
   LI
   LO
   TS
CP0484545
N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]-N'-[[(2R)-1,2,3,4-tetrahydroquinolin-2-yl]methyl]butane-1,4-diamine
   Show/Hide
C23H32N4
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0563697
N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]-N'-[[(2S)-1,2,3,4-tetrahydroquinolin-2-yl]methyl]butane-1,4-diamine
   Show/Hide
C23H32N4
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS