General Information of the Compound
Compound ID
CP0387771
Compound Name
N'-[[(3R)-2-propan-2-yl-3,4-dihydro-1H-isoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
    Show/Hide
Structure
Formula
C26H38N4
Molecular Weight
406.618
Canonical SMILES
CC(C)N1Cc2ccccc2C[C@@H]1CN(CCCCN)[C@H]1CCCc2cccnc12
    Show/Hide
InChI
InChI=1S/C26H38N4/c1-20(2)30-18-23-10-4-3-9-22(23)17-24(30)19-29(16-6-5-14-27)25-13-7-11-21-12-8-15-28-26(21)25/h3-4,8-10,12,15,20,24-25H,5-7,11,13-14,16-19,27H2,1-2H3/t24-,25+/m1/s1
    Show/Hide
InChIKey
XGDFDKUAACCDGW-RPBOFIJWSA-N
Physicochemical Property
logP
4.3352
Rotatable Bonds
8
Heavy Atom Count
30
Polar Areas
45.39
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 72546066
ChEMBL ID
CHEMBL3091694
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02059, C-X-C chemokine receptor type 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000501 HeLa-MAGI-CCR5 Homo sapiens (Human)  1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CL000064 Chem-1 Rattus norvegicus (Rat)  1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS