| Compound ID |
Compound Name |
Compound Formula |
|
CP0403392
|
US9085584, 113
Show/Hide
|
C23H22ClN5O2
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0482193
|
1-(2,6-dichlorophenyl)-N-ethyl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C19H15Cl2N5O
|
1
|
| 1 |
IC50 = 0.28 nM
|
|
|
|
CP0425613
|
N-benzyl-1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C24H18ClN5O
|
1
|
| 1 |
IC50 = 0.38 nM
|
|
|
|
CP0425611
|
1-(2-chlorophenyl)-4-methyl-N-(pyridin-2-ylmethyl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C23H17ClN6O
|
1
|
| 1 |
IC50 = 0.42 nM
|
|
|
|
CP0385743
|
1-(2-chlorophenyl)-4-methyl-N-(2-morpholin-4-ylethyl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C23H23ClN6O2
|
1
|
| 1 |
IC50 = 0.47 nM
|
|
|
|
CP0450415
|
1-(2-chlorophenyl)-N-ethyl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C19H16ClN5O
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0540141
|
1-benzofuran-5-yl-[(3S,4R)-3-[5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-4-methylpiperidin-1-yl]methanone
Show/Hide
|
C21H19F2N5O2
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0013428
|
N-[(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C19H18F4N4O5
|
1
|
| 1 |
IC50 = 0.61 nM
|
|
|
|
CP0408315
|
US9085584, 69
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|
C23H24ClN5O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0438211
|
US9085584, 91
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|
C22H22ClN5O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0459958
|
US9085584, 9
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|
C18H14ClN5O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0463186
|
US9085584, 88
Show/Hide
|
C22H20ClN5O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0538395
|
US9085584, 94
Show/Hide
|
C23H22ClN5O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0500072
|
1-benzofuran-5-yl-[3-[5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-4-methylpiperidin-1-yl]methanone
Show/Hide
|
C21H19F2N5O2
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0542606
|
5-(difluoromethyl)-7-[(3S,4R)-4-methyl-1-(4-phenylpyridin-2-yl)piperidin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidine
Show/Hide
|
C23H22F2N6
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0565855
|
1-(2-chlorophenyl)-N-[2-(diethylamino)ethyl]-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C23H25ClN6O
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0542605
|
(1-methylsulfonylindol-5-yl)-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C20H20N6O3S
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0567258
|
7-methoxy-N-[(1S)-2-methoxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C19H19F3N4O5
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0381821
|
1-(2-chlorophenyl)-4-methyl-N-(2-phenylethyl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C25H20ClN5O
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0484240
|
[(3S,4R)-3-[5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-4-methylpiperidin-1-yl]-(3,4-dimethoxyphenyl)methanone
Show/Hide
|
C21H23F2N5O3
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0415066
|
US9085584, 8
Show/Hide
|
C18H16FN5O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0459023
|
US9085584, 92
Show/Hide
|
C22H22FN5O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0491018
|
US9085584, 68
Show/Hide
|
C24H27N5O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0535019
|
1-[5-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carbonyl]indol-1-yl]ethanone
Show/Hide
|
C21H20N6O2
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0482195
|
1-(2-chlorophenyl)-4-methyl-N-(2-pyrrolidin-1-ylethyl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C23H23ClN6O
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0498444
|
(1-methylsulfonylindol-5-yl)-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C20H20N6O3S
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0414199
|
4-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
Show/Hide
|
C21H20ClN5O
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0450414
|
N-ethyl-1-(2-fluorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C19H16FN5O
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0475345
|
7-methoxy-N-[2-methoxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C19H19F3N4O5
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0488089
|
3-[2-chloro-5-(2,2,2-trifluoroethoxymethyl)phenyl]-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
|
C18H13ClF3N5O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0413898
|
US9085584, 2
Show/Hide
|
C16H12ClN5O
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
|
CP0425069
|
US9085584, 35a
Show/Hide
|
C21H20ClN5O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0431786
|
US9085584, 5
Show/Hide
|
C18H14FN5O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0434743
|
US9085584, 66
Show/Hide
|
C23H24FN5O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0462825
|
US9085584, 103
Show/Hide
|
C24H25N5O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0508734
|
US9085584, 7
Show/Hide
|
C19H19N5O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0546113
|
US9085584, 6
Show/Hide
|
C19H17N5O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0459033
|
US9085584, 32
Show/Hide
|
C21H20ClN5O2
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 26 nM
|
|
|
|
CP0535021
|
[3-[5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
Show/Hide
|
C20H21F2N5OS
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0513495
|
7-cyclopropyl-N-[2-methoxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C21H21F3N4O4
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0498445
|
[3-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
Show/Hide
|
C20H23N5OS
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0468158
|
US9085584, 61
Show/Hide
|
C20H20ClN5O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0470047
|
US9085584, 77
Show/Hide
|
C21H22ClN5O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0543527
|
US9085584, 83
Show/Hide
|
C22H22ClN5O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0385716
|
US9085584, 27
Show/Hide
|
C19H18ClN5O2
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 18 nM
|
|
|
|
CP0418082
|
US9085584, 33
Show/Hide
|
C20H17ClF3N5O2
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 5 nM
|
|
|
|
CP0435545
|
ethyl 1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxylate
Show/Hide
|
C19H15ClN4O2
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0521463
|
4-[[1-(2-chloro-5-propan-2-yloxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
Show/Hide
|
C24H26ClN5O2
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0481488
|
1-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]pyrrolidin-3-ol
Show/Hide
|
C21H20ClN5O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0402816
|
US11419874, Example 7
Show/Hide
|
C22H22ClN5O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0441453
|
US9085584, 95
Show/Hide
|
C23H22FN5O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0482330
|
N-ethyl-1-(2-methoxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C20H19N5O2
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0486899
|
3-(5-butoxy-2-chlorophenyl)-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
|
C19H18ClN5O
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0382539
|
US9085584, 84
Show/Hide
|
C22H20FN5O
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0396419
|
US9085584, 32a
Show/Hide
|
C23H22ClN5O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0413987
|
US9085584, 85
Show/Hide
|
C21H20ClN5O
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0419391
|
4-[[1-(2-chloro-5-ethoxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
Show/Hide
|
C23H24ClN5O2
|
1
|
| 1 |
IC50 = 6.1 nM
|
|
|
|
CP0385740
|
N-ethyl-4-methyl-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C19H17N5O
|
1
|
| 1 |
IC50 = 6.2 nM
|
|
|
|
CP0453340
|
1-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]piperidin-3-ol
Show/Hide
|
C22H22ClN5O
|
1
|
| 1 |
IC50 = 6.3 nM
|
|
|
|
CP0481490
|
N-ethyl-4-methyl-1-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C19H18N6O
|
1
|
| 1 |
IC50 = 6.3 nM
|
|
|
|
CP0482864
|
4-[[1-(2-chloro-5-propoxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
Show/Hide
|
C24H26ClN5O2
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0459013
|
US9085584, 81
Show/Hide
|
C23H25N5O
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0538100
|
US9085584, 107
Show/Hide
|
C22H20FN5O3
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0472454
|
US9085584, 31
Show/Hide
|
C20H20ClN5O2
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 8 nM
|
|
|
|
CP0450478
|
1-(2-chlorophenyl)-4-methyl-8-[(4-methylpiperazin-1-yl)methyl]-[1,2,4]triazolo[4,3-a]quinoxaline
Show/Hide
|
C22H23ClN6
|
1
|
| 1 |
IC50 = 7.1 nM
|
|
|
|
CP0482191
|
1-(2-chlorophenyl)-4-methyl-N-(oxan-4-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-8-amine
Show/Hide
|
C21H20ClN5O
|
1
|
| 1 |
IC50 = 7.3 nM
|
|
|
|
CP0508762
|
4-[[1-(5-butoxy-2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
Show/Hide
|
C25H28ClN5O2
|
1
|
| 1 |
IC50 = 7.7 nM
|
|
|
|
CP0388918
|
US9085584, 59
Show/Hide
|
C20H20ClN5O
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0417812
|
US9085584, 47
Show/Hide
|
C22H22FN5O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0468099
|
US9085584, 48
Show/Hide
|
C23H25N5O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0468770
|
N-[2-methoxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-7-methyl-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C19H19F3N4O4
|
1
|
| 1 |
IC50 = 8.7 nM
|
|
|
|
CP0447959
|
N-ethyl-1-(5-methoxypyridin-3-yl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C19H18N6O2
|
1
|
| 1 |
IC50 = 8.9 nM
|
|
|
|
CP0375687
|
US9085584, 12
Show/Hide
|
C16H9ClF3N5O
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0527399
|
US9085584, 51
Show/Hide
|
C23H27N5O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0385891
|
US9085584, 28
Show/Hide
|
C18H16ClN5O2
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
|
CP0385892
|
US9085584, 35
Show/Hide
|
C19H18ClN5O2
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 17 nM
|
|
|
|
CP0418083
|
US9085584, 34
Show/Hide
|
C19H18ClN5O2
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 17 nM
|
|
|
|
CP0481487
|
1-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]piperidin-4-ol
Show/Hide
|
C22H22ClN5O
|
1
|
| 1 |
IC50 = 9.7 nM
|
|
|
|
CP0389452
|
3-[2-chloro-5-(propan-2-yloxymethyl)phenyl]-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
|
C19H18ClN5O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0402820
|
US9085584, 80
Show/Hide
|
C22H22FN5O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0409797
|
US9085584, 78
Show/Hide
|
C22H25N5O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0532944
|
4,5,6,7-tetrahydro-1-benzothiophen-2-yl-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C19H21N5OS
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0532947
|
7-[1-(4,5,6,7-tetrahydro-1-benzothiophene-2-carbonyl)piperidin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidine-5-carbonitrile
Show/Hide
|
C20H20N6OS
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0090153
|
4-[[1-(5-butoxypyridin-3-yl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
Show/Hide
|
C24H28N6O2
|
1
|
| 1 |
IC50 = 10.1 nM
|
|
|
|
CP0398225
|
4-[[1-(2-chloro-5-methoxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
Show/Hide
|
C22H22ClN5O2
|
1
|
| 1 |
IC50 = 10.4 nM
|
|
|
|
CP0462807
|
US9085584, 52
Show/Hide
|
C22H24FN5O2
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0542666
|
US9085584, 62
Show/Hide
|
C19H18ClN5O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0481489
|
4-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]amino]cyclohexan-1-ol
Show/Hide
|
C22H22ClN5O
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0527413
|
US11419874, Example 8
Show/Hide
|
C22H23N5O
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0573430
|
4-[[1-(5-methoxypyridin-3-yl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
Show/Hide
|
C21H22N6O2
|
1
|
| 1 |
IC50 = 12.1 nM
|
|
|
|
CP0225130
|
1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline
Show/Hide
|
C16H11ClN4
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0385742
|
1-(2-chlorophenyl)-8-[(4-methoxypiperidin-1-yl)methyl]-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline
Show/Hide
|
C23H24ClN5O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0440871
|
N-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]-1-phenylmethanamine
Show/Hide
|
C24H20ClN5
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0448308
|
3-(2-chlorophenyl)-7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
|
C15H10ClN5
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0413529
|
US9085584, 1
Show/Hide
|
C15H10ClN5O
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
IC50 = 41 nM
|
|
|
|
CP0527414
|
US9085584, 100
Show/Hide
|
C22H23N5O2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0412276
|
US9085584, 29
Show/Hide
|
C19H18ClN5O2
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
|
CP0487183
|
US9085584, 89
Show/Hide
|
C20H18ClN5O
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0433377
|
N-benzyl-1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C25H20ClN5O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0374614
|
US9085584, 60
Show/Hide
|
C17H14ClN5O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0455341
|
N-[2-methoxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C18H17F3N4O4
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0538446
|
1-[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]-N,N-dimethylmethanamine
Show/Hide
|
C19H18ClN5
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0418081
|
US9085584, 30
Show/Hide
|
C22H20ClF2N5O
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
|
CP0409221
|
N-ethyl-4-methyl-1-(4-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C19H18N6O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0448309
|
3-[2-chloro-5-(propoxymethyl)phenyl]-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
|
C19H18ClN5O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0546829
|
US9085584, 76
Show/Hide
|
C21H20FN5O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0455338
|
2-oxo-N-[1-[4-(trifluoromethoxy)phenyl]propyl]-1H-1,5-naphthyridine-4-carboxamide
Show/Hide
|
C19H16F3N3O3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0409878
|
US9085584, 21
Show/Hide
|
C21H18ClF2N5O
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
IC50 = 70 nM
|
|
|
|
CP0425610
|
[1-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]piperidin-3-yl]methanol
Show/Hide
|
C23H24ClN5O
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0482192
|
N-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]ethanamine
Show/Hide
|
C19H18ClN5
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0474856
|
6-methyl-N-[(1R)-1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C18H17F3N4O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0462078
|
N-[2-hydroxy-2-methyl-1-[4-(trifluoromethoxy)phenyl]propyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C19H19F3N4O4
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0484239
|
7-[(3S)-1-[(2-chloro-6-methylpyridin-4-yl)methyl]piperidin-3-yl]-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine
Show/Hide
|
C18H19ClF2N6
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0550584
|
1-benzofuran-5-yl-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C19H17N5O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0477195
|
N-ethyl-1-(2-methoxypyridin-3-yl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C19H18N6O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0385890
|
US9085584, 20
Show/Hide
|
C20H18ClN5O2
|
2
|
| 1 |
IC50 = 28 nM
|
|
|
| 2 |
IC50 = 77 nM
|
|
|
|
CP0414049
|
N-ethyl-4-methyl-1-pyridin-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C18H16N6O
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0147040
|
US11419874, Example 28
Show/Hide
|
C15H10ClN5
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0553655
|
N-[2-methylsulfonyl-1-[4-(trifluoromethoxy)phenyl]ethyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C18H17F3N4O5S
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0433369
|
ethyl 4-methyl-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxylate
Show/Hide
|
C19H16N4O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0542604
|
[3-[5-(difluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl]piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
Show/Hide
|
C21H22F2N4OS
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0482863
|
4-[[4-methyl-1-(5-propoxypyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
Show/Hide
|
C23H26N6O2
|
1
|
| 1 |
IC50 = 30.5 nM
|
|
|
|
CP0470058
|
US9085584, 72
Show/Hide
|
C22H22FN5O
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0456754
|
US9085584, 49
Show/Hide
|
C20H18ClN5O2
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0470539
|
7-chloro-N-[2-methoxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C18H16ClF3N4O4
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0425030
|
US9085584, 12a
Show/Hide
|
C17H12F3N5O
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0472607
|
US9085584, 25
Show/Hide
|
C20H18ClN5O2
|
2
|
| 1 |
IC50 = 38 nM
|
|
|
| 2 |
IC50 = 55 nM
|
|
|
|
CP0435544
|
N-ethyl-4-methyl-1-pyridin-3-yl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
|
C18H16N6O
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0479323
|
US9085584, 15
Show/Hide
|
C17H14ClN5O2
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 112 nM
|
|
|
|
CP0462079
|
N-[2-methoxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-6-methyl-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C19H19F3N4O4
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0567257
|
N-[1-[3-fluoro-4-(trifluoromethoxy)phenyl]propyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C18H16F4N4O3
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0524244
|
US9085584, 96
Show/Hide
|
C21H17ClF3N5O2
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0390440
|
US9085584, 64
Show/Hide
|
C20H20ClN5O
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0468508
|
US9085584, 101
Show/Hide
|
C22H22FN5O
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0540142
|
(3,4-dimethoxyphenyl)-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C19H21N5O3
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0542607
|
2,3-dihydro-1,4-benzodioxin-6-yl-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C19H19N5O3
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0545223
|
US9085584, 46
Show/Hide
|
C20H20ClN5O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0535020
|
4,5,6,7-tetrahydro-1-benzothiophen-2-yl-[3-[5-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]piperidin-1-yl]methanone
Show/Hide
|
C20H20F3N5OS
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0553921
|
(4-methoxyphenyl)-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0411423
|
US9085584, 13
Show/Hide
|
C18H16ClN5O2
|
2
|
| 1 |
IC50 = 53 nM
|
|
|
| 2 |
IC50 = 95 nM
|
|
|
|
CP0495618
|
6-methyl-N-[1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C18H17F3N4O2
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0414237
|
3-(5-butoxypyridin-3-yl)-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
|
C18H18N6O
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0456767
|
US9085584, 54
Show/Hide
|
C22H24ClN5O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0468185
|
US9085584, 16
Show/Hide
|
C18H16ClN5O2
|
2
|
| 1 |
IC50 = 58 nM
|
|
|
| 2 |
IC50 = 98 nM
|
|
|
|
CP0402817
|
US9085584, 11
Show/Hide
|
C16H12ClN5O
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0411935
|
US9085584, 63
Show/Hide
|
C18H16ClN5O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0446586
|
N-[3-methoxy-1-[4-(trifluoromethoxy)phenyl]propyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C19H19F3N4O4
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0510545
|
N-[2-hydroxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C17H15F3N4O4
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0486657
|
[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
Show/Hide
|
C20H23N5O4
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0484316
|
5-(difluoromethyl)-7-[(3S)-1-[(2,6-dimethylpyridin-4-yl)methyl]piperidin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidine
Show/Hide
|
C19H22F2N6
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0385894
|
US9085584, 18
Show/Hide
|
C18H16ClN5O2
|
2
|
| 1 |
IC50 = 71 nM
|
|
|
| 2 |
IC50 = 90 nM
|
|
|
|
CP0553664
|
2-oxo-N-[1-[4-(trifluoromethyl)phenyl]propyl]-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C18H17F3N4O2
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0550845
|
US9085584, 87
Show/Hide
|
C19H16ClN5O
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0484309
|
(3-methoxyphenyl)-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0422627
|
US9085584, 40
Show/Hide
|
C20H18ClN5O2
|
2
|
| 1 |
IC50 = 77 nM
|
|
|
| 2 |
IC50 = 80 nM
|
|
|
|
CP0529477
|
N-[2-methoxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-2-oxo-7-propan-2-yloxy-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C21H23F3N4O5
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0553665
|
N-[1-(4-cyclopropylphenyl)propyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C20H22N4O2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0475344
|
N-[2-methoxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-8-methyl-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C19H19F3N4O4
|
1
|
| 1 |
IC50 = 85 nM
|
|
|
|
CP0402800
|
US9085584, 93
Show/Hide
|
C20H18ClN5O2
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0382548
|
US9085584, 96b
Show/Hide
|
C22H20F3N5O2
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0484314
|
(1-methylsulfonylindol-5-yl)-[(3R)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C20H20N6O3S
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0553977
|
[4-methyl-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
Show/Hide
|
C19H22N6OS
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0484310
|
4,5,6,7-tetrahydro-1-benzothiophen-2-yl-[(2S)-2-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)morpholin-4-yl]methanone
Show/Hide
|
C18H19N5O2S
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0488088
|
3-[2-chloro-5-(2-methoxyethoxy)phenyl]-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
|
C18H16ClN5O2
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0413531
|
US9085584, 17
Show/Hide
|
C18H16ClN5O2
|
2
|
| 1 |
IC50 = 98 nM
|
|
|
| 2 |
IC50 = 162 nM
|
|
|
|
CP0491021
|
US9085584, 103b
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0385470
|
US9085584, 90
Show/Hide
|
C20H18FN5O
|
1
|
| 1 |
IC50 = 103 nM
|
|
|
|
CP0411381
|
US9085584, 102
Show/Hide
|
C21H21N5O
|
1
|
| 1 |
IC50 = 103 nM
|
|
|
|
CP0468273
|
US9085584, 71
Show/Hide
|
C19H18ClN5O
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0546854
|
US9085584, 43a
Show/Hide
|
C19H16ClN5O2
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0573429
|
2-[3-[5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-4-methylpiperidin-1-yl]-N-methylpyridine-4-carboxamide
Show/Hide
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C19H21F2N7O
|
1
|
| 1 |
IC50 = 110 nM
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CP0466700
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US9085584, 26
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C18H16FN5O2
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1
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| 1 |
IC50 = 116 nM
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CP0409883
|
US9085584, 4
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C15H10FN5O
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2
|
| 1 |
IC50 = 120 nM
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| 2 |
IC50 = 138 nM
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CP0547066
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4-[[1-[5-(2-methoxyethoxy)pyridin-3-yl]-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C23H26N6O3
|
1
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| 1 |
IC50 = 123 nM
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CP0411424
|
US9085584, 53
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C20H18FN5O2
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1
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| 1 |
IC50 = 140 nM
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CP0415901
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US9085584, 58
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C20H18ClN5O3
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1
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| 1 |
IC50 = 143 nM
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CP0462986
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US9085584, 79
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C22H25N5O
|
1
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| 1 |
IC50 = 144 nM
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CP0488803
|
US9085584, 19
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C19H18ClN5O2
|
1
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| 1 |
IC50 = 146 nM
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CP0448292
|
3-[2-chloro-5-(trifluoromethoxy)phenyl]-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
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C16H9ClF3N5O
|
1
|
| 1 |
IC50 = 150 nM
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CP0567377
|
US9085584, 3
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C16H13N5O
|
1
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| 1 |
IC50 = 155 nM
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CP0484311
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7-[(3S,4R)-1-(4-tert-butylpyridin-2-yl)-4-methylpiperidin-3-yl]-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine
Show/Hide
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C21H26F2N6
|
1
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| 1 |
IC50 = 155 nM
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CP0381477
|
US9085584, 44
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C19H18ClN5O2
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1
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| 1 |
IC50 = 156 nM
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CP0462003
|
US9085584, 70
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C18H16ClN5O
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1
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| 1 |
IC50 = 163 nM
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CP0499854
|
US9085584, 37
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C20H18ClN5O2
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1
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| 1 |
IC50 = 171 nM
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CP0524289
|
US9085584, 67
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C21H23N5O
|
1
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| 1 |
IC50 = 175 nM
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CP0382560
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US9085584, 73
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C20H19N5O
|
1
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| 1 |
IC50 = 189 nM
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CP0450449
|
3-(2-chlorophenyl)-7-methyl-2,4,5,8,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
|
C15H10ClN5
|
1
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| 1 |
IC50 = 190 nM
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CP0456772
|
US9085584, 50
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C21H21N5O2
|
1
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| 1 |
IC50 = 194 nM
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CP0484243
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[3-(5-methoxy-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
Show/Hide
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C20H23N5O2S
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1
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| 1 |
IC50 = 195 nM
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CP0429589
|
US9085584, 82
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C19H18ClN5O
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1
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| 1 |
IC50 = 199 nM
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CP0546676
|
US9085584, 96a
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C21H17F4N5O2
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1
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| 1 |
IC50 = 199 nM
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CP0499839
|
US9085584, 14
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C20H20ClN5O2
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1
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| 1 |
IC50 = 202 nM
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CP0455340
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N-[1-[2-fluoro-4-(trifluoromethoxy)phenyl]propyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
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C18H16F4N4O3
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1
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| 1 |
IC50 = 210 nM
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CP0474331
|
US9085584, 65
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C20H20FN5O
|
1
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| 1 |
IC50 = 214 nM
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CP0418084
|
US9085584, 36
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C19H19N5O2
|
1
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| 1 |
IC50 = 219 nM
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CP0414101
|
US9085584, 10
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C16H13N5O
|
1
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| 1 |
IC50 = 229 nM
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CP0529994
|
cyclopropyl-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
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C14H17N5O
|
1
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| 1 |
IC50 = 246 nM
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CP0475155
|
2-oxo-N-[1-[4-(trifluoromethoxy)phenyl]butyl]-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
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C19H19F3N4O3
|
1
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| 1 |
IC50 = 250 nM
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CP0425609
|
N-ethyl-4-methyl-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Show/Hide
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C18H16N6O
|
1
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| 1 |
IC50 = 263 nM
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CP0540143
|
4,5,6,7-tetrahydro-1-benzothiophen-2-yl-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)azepan-1-yl]methanone
Show/Hide
|
C20H23N5OS
|
1
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| 1 |
IC50 = 263 nM
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CP0425612
|
ethyl 4-methyl-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylate
Show/Hide
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C19H16N4O2
|
1
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| 1 |
IC50 = 280 nM
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CP0428749
|
4-[4-chloro-3-(7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenyl]morpholine
Show/Hide
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C19H17ClN6O
|
1
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| 1 |
IC50 = 310 nM
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CP0532945
|
[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-[4-(trifluoromethyl)phenyl]methanone
Show/Hide
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C18H16F3N5O
|
1
|
| 1 |
IC50 = 324 nM
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CP0535016
|
phenyl-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C17H17N5O
|
1
|
| 1 |
IC50 = 339 nM
|
|
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CP0440527
|
US9085584, 110b
Show/Hide
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C21H17F4N5O3
|
1
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| 1 |
IC50 = 388 nM
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CP0482862
|
4-[[4-methyl-1-(5-propan-2-yloxypyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
Show/Hide
|
C23H26N6O2
|
1
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| 1 |
IC50 = 404 nM
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CP0491961
|
[3-(7-methylimidazo[1,2-a]pyrimidin-5-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
Show/Hide
|
C21H24N4OS
|
1
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| 1 |
IC50 = 407 nM
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|
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CP0385893
|
US9085584, 38
Show/Hide
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C22H22ClN5O2
|
1
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| 1 |
IC50 = 417 nM
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|
|
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CP0515365
|
US9085584, 86
Show/Hide
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C19H16FN5O
|
1
|
| 1 |
IC50 = 434 nM
|
|
|
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CP0481502
|
US9085584, 110d
Show/Hide
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C21H17F4N5O3
|
1
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| 1 |
IC50 = 467 nM
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CP0484308
|
2-(3,4-dimethoxyphenyl)-1-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]ethanone
Show/Hide
|
C20H23N5O3
|
1
|
| 1 |
IC50 = 479 nM
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CP0462076
|
N-[1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C17H15F3N4O2
|
1
|
| 1 |
IC50 = 480 nM
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CP0474854
|
N-[1-(4-methoxyphenyl)propyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C18H20N4O2
|
1
|
| 1 |
IC50 = 490 nM
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CP0553666
|
N-[1-[4-(azetidin-1-yl)phenyl]propyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C20H23N5O2
|
1
|
| 1 |
IC50 = 500 nM
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CP0535017
|
[3-(2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
Show/Hide
|
C21H25N5OS
|
1
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| 1 |
IC50 = 562 nM
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CP0484312
|
4-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carbonyl]benzonitrile
Show/Hide
|
C18H16N6O
|
1
|
| 1 |
IC50 = 589 nM
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|
|
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CP0459949
|
US9085584, 96c
Show/Hide
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C20H15F4N5O2
|
1
|
| 1 |
IC50 = 591 nM
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CP0475342
|
N-[1-(4-methoxyphenyl)propyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C18H20N4O3
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
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CP0459026
|
US9085584, 103c
Show/Hide
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C19H15F4N5O
|
1
|
| 1 |
IC50 = 622 nM
|
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CP0535023
|
5-(difluoromethyl)-7-[1-[(3,4-dimethoxyphenyl)methyl]piperidin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidine
Show/Hide
|
C20H23F2N5O2
|
1
|
| 1 |
IC50 = 741 nM
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|
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CP0534535
|
N-[(1R)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C19H18F4N4O5
|
1
|
| 1 |
IC50 = 910 nM
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|
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CP0498448
|
(2-methoxyphenyl)-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
IC50 = 912 nM
|
|
|
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CP0481156
|
US9085584, 39
Show/Hide
|
C21H20ClN5O2
|
1
|
| 1 |
IC50 = 914 nM
|
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CP0539033
|
6-cyclopropyl-N-[1-(4-methoxyphenyl)propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C20H22N4O2
|
1
|
| 1 |
IC50 = 1000 nM
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CP0532946
|
7-[1-(1-benzofuran-5-ylmethyl)piperidin-3-yl]-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine
Show/Hide
|
C20H19F2N5O
|
1
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| 1 |
IC50 = 1148 nM
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CP0510665
|
6-chloro-N-[1-(4-methoxyphenyl)propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C17H17ClN4O2
|
1
|
| 1 |
IC50 = 1400 nM
|
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CP0529995
|
4,5,6,7-tetrahydro-1-benzothiophen-2-yl-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]methanone
Show/Hide
|
C18H20N6OS
|
1
|
| 1 |
IC50 = 1412 nM
|
|
|
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CP0527831
|
cyclohexyl-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
Show/Hide
|
C17H23N5O
|
1
|
| 1 |
IC50 = 1580 nM
|
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CP0408130
|
N-[1-(4-methoxyphenyl)propyl]-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C18H20N4O2
|
1
|
| 1 |
IC50 = 2200 nM
|
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CP0428748
|
7-methyl-3-(4-methylpyridin-3-yl)-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
|
C15H12N6
|
1
|
| 1 |
IC50 = 2450 nM
|
|
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CP0484238
|
[3-[5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
Show/Hide
|
C21H22F3N5OS
|
1
|
| 1 |
IC50 = 2951 nM
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CP0408132
|
6-methyl-N-(1-phenylpropyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C17H18N4O
|
1
|
| 1 |
IC50 = 3600 nM
|
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CP0564043
|
N-[1-(4-methoxyphenyl)propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C17H18N4O2
|
1
|
| 1 |
IC50 = 3800 nM
|
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CP0553667
|
2-oxo-N-[1-[3-(trifluoromethoxy)phenyl]propyl]-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C18H17F3N4O3
|
1
|
| 1 |
IC50 = 4100 nM
|
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CP0414238
|
3-(5-chloropyridin-3-yl)-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Show/Hide
|
C14H9ClN6
|
1
|
| 1 |
IC50 = 5750 nM
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CP0910630
|
(RS)-[3-(1H-Pyrrolo[2,3-b]pyridin-4-yl)-1-piperidyl]-(4,5,6,7-tetrahydrobenzothiophen-2-yl)methanone
Show/Hide
|
C21H23N3OS
|
1
|
| 1 |
IC50 = 6020 nM
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CP0542603
|
[3-(5-propan-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
Show/Hide
|
C22H27N5OS
|
1
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| 1 |
IC50 = 6031 nM
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CP0408134
|
6-methyl-N-[[4-(trifluoromethoxy)phenyl]methyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C16H13F3N4O2
|
1
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| 1 |
IC50 = 6100 nM
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CP0529675
|
3-methyl-N-[1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-b][1,2,4]triazine-8-carboxamide
Show/Hide
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C17H16F3N5O2
|
1
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| 1 |
IC50 = 6500 nM
|
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CP0408131
|
N-[1-(4-methoxyphenyl)propyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C19H22N4O2
|
1
|
| 1 |
IC50 = 7000 nM
|
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CP0475343
|
2-oxo-N-[1-[2-(trifluoromethoxy)phenyl]propyl]-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
Show/Hide
|
C18H17F3N4O3
|
1
|
| 1 |
IC50 = 8100 nM
|
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CP0444327
|
[4-[3-(4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
Show/Hide
|
C29H32N4O2
|
2
|
| 1 |
IC50 = 9540 nM
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| 2 |
IC50 = 13340 nM
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CP0000847
|
(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione
Show/Hide
|
C22H19N3O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
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|
CP0010658
|
5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Show/Hide
|
C22H30N6O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
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CP0384486
|
N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C24H35N5O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0484242
|
1-[4-(4,5,6,7-tetrahydro-1-benzothiophene-2-carbonyl)-2-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanone
Show/Hide
|
C20H22N6O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0176508
|
[4-[3-(3-fluoro-4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
Show/Hide
|
C29H31FN4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
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CP0419692
|
N-(2-hydroxyethyl)-4-[3-(4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]benzamide
Show/Hide
|
C26H27N3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0365459
|
[4-[5-tert-butyl-3-(3,5-difluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
Show/Hide
|
C26H32F2N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0419693
|
[4-[5-tert-butyl-3-(2,3-difluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
Show/Hide
|
C26H32F2N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0447148
|
N-[1-(4-methoxyphenyl)propyl]-2-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C18H20N4O2
|
1
|
| 1 |
IC50 = 16000 nM
|
|
|
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CP0455339
|
5-oxo-N-[1-[4-(trifluoromethoxy)phenyl]propyl]-6H-1,6-naphthyridine-8-carboxamide
Show/Hide
|
C19H16F3N3O3
|
1
|
| 1 |
IC50 = 19000 nM
|
|
|
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CP0109248
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(2S,8R)-2-(5-bromothiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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C19H16BrN3O2S
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1
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| 1 |
IC50 > 20000 nM
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CP0109250
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(2S,8R)-6-methyl-2-(5-methylthiophen-2-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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C20H19N3O2S
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1
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| 1 |
IC50 > 20000 nM
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CP0144390
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(2S,8R)-2-(5-ethylfuran-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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C21H21N3O3
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1
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| 1 |
IC50 > 20000 nM
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CP0157968
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(10S,15S)-13-ethyl-10-(5-methylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C20H19N3O3
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1
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| 1 |
IC50 > 20000 nM
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CP0157969
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(10S,15S)-13-ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O2S
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1
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| 1 |
IC50 > 20000 nM
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CP0164472
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(10S,15R)-13-ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O2S
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1
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| 1 |
IC50 > 20000 nM
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CP0168902
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(10S,15R)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O3
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1
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| 1 |
IC50 > 20000 nM
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CP0257911
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(10S,15S)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O3
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1
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| 1 |
IC50 > 20000 nM
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CP0268684
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(2S,8R)-2-(5-ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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C21H21N3O2S
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1
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| 1 |
IC50 > 20000 nM
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CP0392073
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(10S,15S)-13-butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C23H25N3O2S
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1
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| 1 |
IC50 > 20000 nM
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CP0392075
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(10R,15R)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O3
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1
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| 1 |
IC50 > 20000 nM
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CP0392491
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(2R,8S)-2-(5-ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
Show/Hide
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C21H21N3O2S
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1
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| 1 |
IC50 > 20000 nM
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CP0432292
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(10S,15R)-13-butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C23H25N3O2S
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1
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| 1 |
IC50 > 20000 nM
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CP0440103
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(10S,15S)-13-ethyl-10-(3-methylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C20H19N3O2S
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1
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| 1 |
IC50 > 20000 nM
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CP0474852
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6-[1-(4-methoxyphenyl)propyl]-1,2,6-triazatricyclo[6.3.1.04,12]dodeca-2,4(12),8,10-tetraen-5-one
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C19H19N3O2
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1
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| 1 |
IC50 = 21000 nM
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CP0548729
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N-[1-(4-methoxyphenyl)propyl]-6-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
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C23H22N4O2
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1
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| 1 |
IC50 = 23000 nM
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CP0564044
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6-methyl-N-(1-phenylethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
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C16H16N4O
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1
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| 1 |
IC50 = 28000 nM
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CP0567259
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7-methoxy-N-[(1R)-2-methoxy-1-[4-(trifluoromethoxy)phenyl]ethyl]-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
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C19H19F3N4O5
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1
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| 1 |
IC50 = 39000 nM
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CP0408133
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N-(2,3-dihydro-1H-inden-1-yl)-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
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C17H16N4O
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1
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| 1 |
IC50 = 49000 nM
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CP0564777
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N-[(4-methoxyphenyl)methyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
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C16H16N4O2
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1
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| 1 |
IC50 = 52000 nM
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CP0462077
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3-oxo-N-[1-[4-(trifluoromethoxy)phenyl]propyl]-2,4-dihydroquinoxaline-1-carboxamide
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C19H18F3N3O3
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1
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| 1 |
IC50 = 70000 nM
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CP0394353
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1-(4-methoxyphenyl)-N-[(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]propan-1-amine
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C18H22N4O
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1
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| 1 |
IC50 > 100000 nM
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CP0474853
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N-[1-(4-methoxyphenyl)propyl]pyrazolo[1,5-a]pyridine-3-carboxamide
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C18H19N3O2
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1
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| 1 |
IC50 > 100000 nM
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CP0474855
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N-[(2-methoxyphenyl)methyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
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C16H16N4O2
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1
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| 1 |
IC50 > 100000 nM
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CP0509513
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N-[1-(4-methoxyphenyl)propyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-sulfonamide
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C17H20N4O3S
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1
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| 1 |
IC50 > 100000 nM
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CP0558991
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N-[(3-methoxyphenyl)methyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
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C16H16N4O2
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1
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| 1 |
IC50 > 100000 nM
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CP0564778
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6-methyl-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
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C18H17F3N4O2
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1
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| 1 |
IC50 > 100000 nM
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CP0564779
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N-[1-(4-methoxyphenyl)propyl]-N,6-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
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C19H22N4O2
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1
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| 1 |
IC50 > 100000 nM
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