| Compound ID |
Compound Name |
Compound Formula |
|
CP0007430
|
IBRUTINIB
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|
C25H24N6O2
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0088490
|
US10894048, Ref. Ex Comp. 1
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|
C25H24N6O2
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0060760
|
US9447106, 27b (peak 2)
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|
C27H29N5O3
|
2
|
| 1 |
IC50 = 5.4 nM
|
|
|
| 2 |
IC50 = 11.5 nM
|
|
|
|
CP0545773
|
3-amino-5-[4-[[4-(4-chlorophenyl)pyridin-2-yl]carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide
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|
C30H28ClN7O3
|
1
|
| 1 |
IC50 = 11.3 nM
|
|
|
|
CP0551189
|
2-(4-phenoxyphenyl)-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide
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|
C26H23N5O3
|
1
|
| 1 |
IC50 = 14.1 nM
|
|
|
|
CP0549768
|
2-[4-(2-fluorophenoxy)phenyl]-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide
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|
C26H22FN5O3
|
1
|
| 1 |
IC50 = 14.4 nM
|
|
|
|
CP0479464
|
2-(4-phenoxyphenyl)-7-(1-prop-2-ynoylazetidin-3-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide
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|
C24H19N5O3
|
1
|
| 1 |
IC50 = 21.4 nM
|
|
|
|
CP0946598
|
2-(4-phenoxyphenyl)-7-(1-propioloylpyrrolidin-3-yl)-1Himidazo[1,2-b]pyrazole-3-carboxamide
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|
C25H21N5O3
|
1
|
| 1 |
IC50 = 27.5 nM
|
|
|
|
CP0538473
|
2-[4-(2,4-difluorophenoxy)phenyl]-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide
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|
C26H21F2N5O3
|
1
|
| 1 |
IC50 = 34.4 nM
|
|
|
|
CP0538474
|
CHEMBL4856592
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|
C27H25N5O4
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0072678
|
5-(1,3-benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amine
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|
C20H21N5O4S
|
1
|
| 1 |
IC50 = 35.7 nM
|
|
|
|
CP0547157
|
3-amino-5-[4-[[4-(4-fluorophenyl)pyridin-2-yl]carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide
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|
C30H28FN7O3
|
1
|
| 1 |
IC50 = 46.8 nM
|
|
|
|
CP0538470
|
2-[4-(4-methoxyphenoxy)phenyl]-7-(1-prop-2-ynoylazetidin-3-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide
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|
C25H21N5O4
|
1
|
| 1 |
IC50 = 73.4 nM
|
|
|
|
CP0491433
|
3-amino-5-[4-[(4-chloropyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide
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|
C24H24ClN7O3
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0914195
|
2-(4-(2-methoxyphenoxy)phenyl)-7-(1-propioloylpyrrolidin-3-yl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide
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|
C26H23N5O4
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0551070
|
CHEMBL4878090
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|
C27H25N5O3
|
1
|
| 1 |
IC50 = 97.2 nM
|
|
|
|
CP0561985
|
3-amino-5-[4-[(4-phenylpyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide
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|
C30H29N7O3
|
1
|
| 1 |
IC50 = 114 nM
|
|
|
|
CP0906831
|
2-(4-(4-fluorophenoxy)phenyl)-7-(1-propioloylpyrrolidin-3-yl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide
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|
C25H20FN5O3
|
1
|
| 1 |
IC50 = 121 nM
|
|
|
|
CP0485099
|
CHEMBL4863078
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|
C26H25N5O3
|
1
|
| 1 |
IC50 = 179 nM
|
|
|
|
CP0551206
|
3-amino-5-[4-[(4-bromopyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide
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|
C24H24BrN7O3
|
1
|
| 1 |
IC50 = 184 nM
|
|
|
|
CP0561983
|
3-amino-5-[4-[(4-methoxypyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide
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|
C25H27N7O4
|
1
|
| 1 |
IC50 = 338 nM
|
|
|
|
CP0086121
|
ACP-196
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|
C26H23N7O2
|
1
|
| 1 |
IC50 = 598 nM
|
|
|
|
CP0243780
|
3-amino-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]-5-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazole-4-carboxamide
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|
C25H24F3N7O3
|
1
|
| 1 |
IC50 = 857 nM
|
|
|
|
CP0547464
|
3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(4-phenylpyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide
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|
C31H29N7O3
|
1
|
| 1 |
IC50 = 903 nM
|
|
|
|
CP0545774
|
3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(4-chloropyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide
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|
C25H24ClN7O3
|
1
|
| 1 |
IC50 = 3671 nM
|
|
|
|
CP0491434
|
3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazole-4-carboxamide
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|
C26H24F3N7O3
|
1
|
| 1 |
IC50 = 8615 nM
|
|
|
