Brief Information of the Cell Line and Protein
Cell Line ID: CL000012 , Sf21
Synonyms
SF21
Sf-21
SF-21
IPLB-SF-21-AE
IPLB-Sf21-AE
IPLB-SF21-AE
IPLB-SF 21AE
IPLB-Sf21AE
IPLB-SF21AE
IPLB-SF-21
IPLB-Sf-21
IPLB-SF 21
IPLB-Sf21
IPLB-SF21
Category Spontaneously immortalized cell line
Organism
Spodoptera frugiperda (Fall armyworm)
Cellosaurus ID
CVCL_0518
Protein ID: PT01592 , Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Gene Name DYRK1A
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q13627
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000012  Protein ID: PT01592
 
Compound ID Compound Name Compound Formula
CP0270792
(2S,6R)-N-[4-[1-(4-hydroxy-4-methylcyclohexyl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]-2,6-dimethylmorpholine-4-carboxamide
   Show/Hide
C26H33N5O3
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0074483
4-ethyl-N-[4-[1-(oxan-4-yl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]piperazine-1-carboxamide
   Show/Hide
C24H30N6O2
 1
1
IC50 = 6.2 nM
   TI
   LI
   LO
   TS
CP0868382
3-[8-Fluoro-4-(pyridin-3-yl)quinolin-6-yl]-N-methyl-N-(prop-2-en-1-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C26H20FN5O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0868383
3-{4-[(4-Aminocyclohexyl)amino]-3-nitroquinolin-6-yl}-N-(pyridin-3-ylmethyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C29H29ClN8O3
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0870241
3-[8-Fluoro-4-(pyridin-3-yl)quinolin-6-yl]-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C23H16FN5O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0870242
3-[8-Methoxy-4-(pyridin-3-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C23H17N5O2
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0870243
N-Methyl-3-[4-(morpholin-4-yl)-3-[(oxan-4-ylmethyl)amino]quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C28H32N6O3
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0870244
4-(Pyridin-4-yl)-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline
   Show/Hide
C21H14N4
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0870245
8-Methyl-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline hydrochloride
   Show/Hide
C17H14ClN3
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0870246
6-{1H-Pyrrolo[2,3-b]pyridin-3-yl}quinoline
   Show/Hide
C16H11N3
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0871639
N-Methyl-N-(1-methylpiperidin-4-yl)-3-nitro-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinolin-4-amine
   Show/Hide
C23H24N6O2
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0903314
3-{3-[(Oxan-4-ylmethyl)amino]quinolin-6-yl}-N-(pyridin-3-ylmethyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C29H28N6O2
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0911261
3-{4-[(3S)-3-Aminopiperidin-1-yl]-3-nitroquinolin-6-yl}-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C23H24ClN7O3
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0911262
3-(3-{[(3-Chlorophenyl)methyl]amino}-4-(morpholin-4-yl)quinolin-6-yl)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C29H27ClN6O2
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0924808
3-(4-Chloroquinolin-6-yl)-N-methyl-N-(prop-2-en-1-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbomide
   Show/Hide
C21H17ClN4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0924813
(3R)-1-(6-{5-[(Benzylamino)methyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-8-fluoroquinolin-4-yl)piperidin-3-amine
   Show/Hide
C29H29FN6
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0924814
4-(Pyridin-3-yl)-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline
   Show/Hide
C21H14N4
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0924815
3-(3-Acetamidoquinolin-6-yl)-N-(pyridin-3-ylmethyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C25H20N6O2
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0924822
N-Methyl-3-[4-(pyridin-3-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C23H17N5O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0942969
N-Benzyl-3-(8-chloroquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C24H17ClN4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0956127
N-(3-Aminopropyl)-3-(8-chloroquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C20H19Cl2N5O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0956128
N-(1-Methylpiperidin-4-yl)-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinolin-4-amine
   Show/Hide
C22H23N5
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0956129
6-{1H-Pyrrolo[2,3-b]pyridin-3-yl}-8-(trifluoromethoxy)quinoline
   Show/Hide
C17H10F3N3O
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0956130
8-Methyl-4-(pyridin-3-yl)-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline
   Show/Hide
C22H16N4
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0956131
8-Fluoro-4-(pyridin-3-yl)-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline
   Show/Hide
C21H13FN4
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0956132
3-(8-Methoxyquinolin-6-yl)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C19H16N4O2
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0956133
N-(3-Aminopropyl)-3-[8-fluoro-4-(pyridin-3-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C25H22ClFN6O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0956134
3-[8-Fluoro-4-(pyridin-3-yl)quinolin-6-yl]-N-(pyridin-3-ylmethyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C28H19FN6O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0956135
({3-[8-Fluoro-4-(pyridin-3-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}methyl)(methyl)(prop-2-en-1-yl)amine
   Show/Hide
C26H22FN5
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0956136
3-[3-Acetamido-4-(morpholin-4-yl)quinolin-6-yl]-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C24H24N6O3
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0956137
3-(3-Aminoquinolin-6-yl)-N-(pyridin-3-ylmethyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C23H18N6O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0958177
3-(8-Fluoroquinolin-6-yl)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C18H13FN4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0958178
N-Benzyl-3-[8-fluoro-4-(pyridin-3-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C29H20FN5O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0959634
N-Benzyl-3-(8-fluoroquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C24H17FN4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0959635
3-(8-Fluoroquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C17H11FN4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0959636
Benzyl({3-[8-fluoro-4-(pyridin-3-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}methyl)amine
   Show/Hide
C29H22FN5
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0959637
(3S)-1-(6-{1H-Pyrrolo[2,3-b]pyridin-3-yl}quinolin-4-yl)piperidin-3-amine
   Show/Hide
C21H21N5
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0959755
3-{3-Amino-4-[(3S)-3-aminopiperidin-1-yl]quinolin-6-yl}-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C23H26ClN7O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0959756
8-Fluoro-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline
   Show/Hide
C16H10FN3
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0959940
3-{4-[(3R)-3-Aminopiperidin-1-yl]-8-fluoroquinolin-6-yl}-N-(pyrimidin-5-ylmethyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C27H26ClFN8O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0961055
4-Phenyl-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline
   Show/Hide
C22H15N3
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0961124
3-(4-Chloroquinolin-6-yl)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C18H13ClN4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0961940
N-(3-Aminopropyl)-3-(8-fluoroquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C20H19ClFN5O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0961941
3-[8-Fluoro-4-(2-phenylethyl)quinolin-6-yl]-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C26H21FN4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0961942
3-{4-[(4-Aminocyclohexyl)amino]-3-[(oxan-4-ylmethyl)amino]quinolin-6-yl}-N-(pyridin-3-ylmethyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C35H41ClN8O2
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0961943
N-{3-[8-Fluoro-4-(pyridin-3-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetamide
   Show/Hide
C23H16FN5O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0961953
8-Methoxy-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline
   Show/Hide
C17H13N3O
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0961954
N-Methyl-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C18H14N4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0962466
N-(Furan-3-ylmethyl)-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinolin-3-amine
   Show/Hide
C21H16N4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0962467
Methyl({3-[4-(pent-4-en-1-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}methyl)(prop-2-en-1-yl)amine
   Show/Hide
C26H28N4
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0962468
N-Methyl-3-[8-methyl-4-(pyridin-3-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C24H19N5O
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0962470
3-{4-[(3R)-3-Aminopiperidin-1-yl]-8-fluoroquinolin-6-yl}-N-(pyridin-3-ylmethyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C28H27ClFN7O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0962471
3-{4-[(3S)-3-Aminopiperidin-1-yl]-3-{[(3-chlorophenyl)methyl]amino}quinolin-6-yl}-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C30H31Cl2N7O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0962709
N-Methyl-3-[4-(morpholin-4-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C22H21N5O2
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0965933
{5-Ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinolin-4-yl)methanol
   Show/Hide
C26H26N4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0965936
3-(8-Chloroquinolin-6-yl)-N-methyl-N-(prop-2-en-1-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C21H17ClN4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0965992
4-[(1-Methylpiperidin-4-yl)amino]-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline-3-carbonitrile
   Show/Hide
C23H22N6
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0966681
3-{4-[(3R)-3-Aminopiperidin-1-yl]-8-fluoroquinolin-6-yl}-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C23H24ClFN6O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0966682
1-{4-[(3-Amino-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinolin-4-yl)amino]piperidin-1-yl}ethan-1-one
   Show/Hide
C23H24N6O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0966683
3-{4-[(3S)-3-Aminopiperidin-1-yl]-8-fluoroquinolin-6-yl}-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride
   Show/Hide
C23H24ClFN6O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0966684
N-Methyl-3-[8-fluoro-4-(4-methylpyridin-3-yl)quinolin-6-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C24H18FN5O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0967052
3-(8-Fluoroquinolin-6-yl)-N-methyl-N-(prop-2-en-1-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
   Show/Hide
C21H17FN4O
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0968434
8-Chloro-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline hydrochloride
   Show/Hide
C16H11Cl2N3
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0532055
3,3-dimethyl-N-[4-[1-(oxan-4-yl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]azetidine-1-carboxamide
   Show/Hide
C23H27N5O2
 1
1
IC50 = 11.6 nM
   TI
   LI
   LO
   TS
CP0493840
1-phenyl-3-pyridin-4-ylpyrrolo[2,3-c]pyridine
   Show/Hide
C18H13N3
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0349959
1-cyclopropyl-3-[4-(1-phenylpyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl]urea
   Show/Hide
C22H19N5O
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0396847
4-(1-phenylpyrrolo[2,3-c]pyridin-3-yl)pyridin-2-amine
   Show/Hide
C18H14N4
 1
1
IC50 = 16.7 nM
   TI
   LI
   LO
   TS
CP0535419
1-cyclopropyl-3-[4-[1-(oxan-4-yl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]urea
   Show/Hide
C21H23N5O2
 1
1
IC50 = 17.1 nM
   TI
   LI
   LO
   TS
CP0349958
N-[4-[1-(oxan-4-yl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]morpholine-4-carboxamide
   Show/Hide
C22H25N5O3
 1
1
IC50 = 24.5 nM
   TI
   LI
   LO
   TS
CP0414623
1-(2-methylpropyl)-3-pyridin-4-ylpyrrolo[2,3-c]pyridine
   Show/Hide
C16H17N3
 1
1
IC50 = 43 nM
   TI
   LI
   LO
   TS
CP0074461
(2S,6R)-2,6-dimethyl-N-[4-[1-(oxan-4-yl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]morpholine-4-carboxamide
   Show/Hide
C24H29N5O3
 1
1
IC50 = 43.3 nM
   TI
   LI
   LO
   TS
CP0409349
1-benzyl-3-pyridin-4-ylpyrrolo[2,3-c]pyridine
   Show/Hide
C19H15N3
 1
1
IC50 = 106 nM
   TI
   LI
   LO
   TS
CP0532052
1-(cyclopropylmethyl)-3-pyridin-4-ylpyrrolo[2,3-c]pyridine
   Show/Hide
C16H15N3
 1
1
IC50 = 109 nM
   TI
   LI
   LO
   TS
CP0532054
1-(2-methoxyethyl)-3-pyridin-4-ylpyrrolo[2,3-c]pyridine
   Show/Hide
C15H15N3O
 1
1
IC50 = 272 nM
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CP0477527
N-[4-(1-phenylpyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl]cyclopropanecarboxamide
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C22H18N4O
 1
1
IC50 = 301 nM
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CP0396849
1-[(3-methyloxetan-3-yl)methyl]-3-pyridin-4-ylpyrrolo[2,3-c]pyridine
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C17H17N3O
 1
1
IC50 = 315 nM
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CP0390388
1-(oxan-4-yl)-3-pyridin-4-ylpyrrolo[2,3-c]pyridine
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C17H17N3O
 1
1
IC50 = 352 nM
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CP0959754
3-(8-Methoxyquinolin-6-yl)-N-methyl-N-(prop-2-en-1-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C22H20N4O2
 1
1
IC50 >= 100 nM
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CP0966680
8-Methyl-4-phenyl-6-{1H-pyrrolo[2,3-b]pyridin-3-yl}quinoline
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C23H17N3
 1
1
IC50 >= 100 nM
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