Brief Information of the Cell Line and Protein
Cell Line ID: CL000263 , NCI-H295R
Synonyms
NCI H295R
NCIH295R
H295R
H-295R
H295R-S1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0458
Protein ID: PT01584 , Steroid 17-alpha-hydroxylase/17,20 lyase
Gene Name CYP17A1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P05093
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000263  Protein ID: PT01584
 
Compound ID Compound Name Compound Formula
CP0035494
(1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-(pyridin-3-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-7,13-dien-5-ol
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C24H31NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0183543
(8R,9S,10R,13S,14S)-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
   Show/Hide
C19H28O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0847245
(5aS,5bS,7aS,10aS,10bR)-5a,7a,12-trimethyl-8-(pyridin-3-yl)-3,4,5,5a,5b,6,7,7a,10,10a,11,12-dodecahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(10bH)-one
   Show/Hide
C25H32N2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0851646
(5aS,5bS,7aS,10aS,10bR,12aS)-5a,7a-dimethyl-8-(1H-1,2,3-triazol-1-yl)-3,4,5,5a,5b,6,7,7a,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(1H)-one
   Show/Hide
C21H30N4O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0851665
(3S,8R,9S,10R,13S,14S)-17-(5-(difluoromethyl)pyridin-3-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
   Show/Hide
C25H31F2NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0851672
(3S,8R,9S,10R,13S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13-decahydro-1H-cyclopenta[a]phenanthren-3-ol
   Show/Hide
C24H29NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0856551
(3aS,3bS,5aS,8aS,8bR,10aS)-6-(1H-imidazol-1-yl)-3a,5a-dimethyl-1,2,3,3a,3b,4,5,5a,8,8a,8b,9,10,10a-tetradecahydrodicyclopenta[a,f]naphthalen-2-ol
   Show/Hide
C21H30N2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0856558
(8R,9S,10R,13S,14S)-17-(5-fluoropyridin-3-yl)-10,13-dimethyl-8,9,10,11,12,13,14,15-octahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
   Show/Hide
C24H26FNO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0856611
N-((3S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)isobutyramide
   Show/Hide
C28H40N2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0862421
(3aS,5aS)-6-(5-fluoropyridin-3-yl)-3a,5a-dimethyl-1,2,3,3a,3b,4,5,5a,8,8a,8b,9,10,10a-tetradecahydrodicyclopenta[a,f]naphthalen-2-ol
   Show/Hide
C23H30FNO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0862423
(3S,8R,9S,10R,13S)-17-(5-fluoropyridin-3-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13-decahydro-1H-cyclopenta[a]phenanthren-3-ol
   Show/Hide
C24H28FNO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0862426
(4aR,4bS,6aS,9aR,9bR)-4a,6a-dimethyl-7-(pyridin-3-yl)-1a,2,3,4,4a,4b,5,6,6a,9,9a,9b,10,11-tetradecahydro-1H-cyclopenta[a]cyclopropa[j]phenanthren-2-ol
   Show/Hide
C25H33NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0862438
(4R,10S,12R)-17-((S)-5-Fluoro-pyridin-3-yl)-10,13-dimethyl-1,2,7,8,9,10,11,12,13,14,15,20-dodecahydro-6H-cyclopropa[6,7]cyclopenta[a]phenanthren-3-one
   Show/Hide
C25H28FNO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0862439
(8R,9S,10R,13S)-17-(5-fluoropyridin-3-yl)-10,13-dimethyl-6,7,8,9,10,11,12,13-octahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
   Show/Hide
C24H26FNO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0863061
(8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,5,6,7,8,9,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-4(10H)-one
   Show/Hide
C24H31NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0863082
(8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-1,7,8,9,10,11,12,13,14,15-decahydrospiro[cyclopenta[a]phenanthrene-6,1'-cyclopropan]-3(2H)-one
   Show/Hide
C26H31NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0863114
N-((3R,8R,9S,10R,13S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13-decahydro-1H-cyclopenta[a]phenanthren-3-yl)acetamide
   Show/Hide
C26H32N2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0864962
(3S,8R,9S,10R,13S)-17-(5-methoxypyridin-3-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13-decahydro-1H-cyclopenta[a]phenanthren-3-ol
   Show/Hide
C25H31NO2
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0864968
(5aR,5bS,7aS,10aS,10bR)-8-(5-fluoropyridin-3-yl)-5a,7a-dimethyl-3,4,5,5a,5b,6,7,7a,10,10a,10b,10c,11,11a-tetradecahydro-2H-cyclopenta[5,6]cyclopropa[3,4]naphtho[1,2-d]azepin-2-one
   Show/Hide
C25H29FN2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0866302
(8S,9S,10R,13S,14S)-6,10,13-trimethyl-17-(pyridin-3-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthren-3-one
   Show/Hide
C25H29NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0869132
(3aR,3bS,9aR,9bS,11aS)-5,9a,11a-trimethyl-1-(4-methylpyridin-3-yl)-3b,4,5,8,9,9a,9b,10,11,11a-decahydro-3H-cyclopenta[i]phenanthridin-7(3aH)-one
   Show/Hide
C25H32N2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0869162
(3aS,5aS)-3a,5a-dimethyl-6-(pyridin-3-yl)-1,2,3,3a,3b,4,5,5a,8,8a,8b,9,10,10a-tetradecahydrodicyclopenta[a,f]naphthlen-2-ol
   Show/Hide
C23H31NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0870396
(8R,9S,10S,13S,14S)-10,13-dimethyl-6-methylene-17-(pyridin-3-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthren-3-one
   Show/Hide
C25H27NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0870401
N-((3R,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)acetamide
   Show/Hide
C26H34N2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0873026
(8S,9S,10R,13S,14S)-17-(5-fluoropyridin-3-yl)-10,13-dimethyl-6-methylene-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthren-3-one
   Show/Hide
C25H26FNO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0873406
(5aR,5bS,7aS,10bR)-8-(5-fluoropyridin-3-yl)-5a,7a-dimethyl-3,4,5,5a,5b,6,7,7a,11,12-decahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(10bH)-one
   Show/Hide
C24H27FN2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0875207
(3S,8R,9S,10R,13S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13-decahydro-1H-cyclopenta[a]phenanthren-3-yl-2-(dimethylamino)acetate
   Show/Hide
C28H36N2O2
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0875219
(3S,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-(1H-1,2,3-triazol-1-yl)-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
   Show/Hide
C23H33N3O2
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0881254
(3S,8S,9S,10R,13S,14S)-6-fluoro-17-(5-fluoropyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,5-diol
   Show/Hide
C24H31F2NO2
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0882917
(3S,8R,9S,10R,13S)-10,13-dimethyl-17-(4-methylpyridin-3-yl)-2,3,4,7,8,9,10,11,12,13-decahydro-1H-cyclopenta[a]phenanthren-3-ol
   Show/Hide
C25H31NO
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0883791
(8R,9S,10R,13S)-17-(5-fluoropyridin-3-yl)-6,10,13-trimethyl-6,7,8,9,10,11,12,13-octahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
   Show/Hide
C25H28FNO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0888267
(3S,8R,9S,10R,13S)-17-(5-(difluoromethyl)pyridin-3-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13-decahydro-1H-cyclopenta[a]phenanthren-3-ol
   Show/Hide
C25H29F2NO
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0888268
(5aR,5bS,7aS,10aS,10bR)-5a,7a-dimethyl-8-(pyridin-3-yl)-3,4,5,5a,5b,6,7,7a,10,10a,10b,11-dodecahydro-2H-spiro[cyclopenta[5,6]naphtho[1,2-d]azepine-12,1'-cyclopropan]-2-one
   Show/Hide
C26H32N2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0888462
(3S,5S,8R,9S,10S,13S)-17-(1H-imidazol-1-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
   Show/Hide
C22H30N2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0888472
(5aR,5bS,7aS,10aS,10bR)-8-(5-(difluoromethyl)pyridin-3-yl)-5a,7a-dimethyl-3,4,5,5a,5b,6,7,7a,10,10a,11,12-dodecahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(10bH)-one
   Show/Hide
C25H30F2N2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0893649
N-((3R,8R,9S,10R,13S,14S)-17-(1H-imidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)acetamide
   Show/Hide
C24H33N3O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0895707
3-fluoro-5-((8R,9S,10R,13S,14S)-3-fluoro-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine
   Show/Hide
C24H29F2N
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0895916
(9S,8R,10R,13S,14S)-6,10,13-trimethyl-17-(pyridin-3-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
   Show/Hide
C25H31NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0897740
(5aR,5bS,7aS,10aS,10bR)-8-(1H-imidazol-1-yl)-5a,7a-dimethyl-4,5,5a,5b,6,7,7a,10,10a,10b,11,12-dodecahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(3H)-one
   Show/Hide
C22H29N3O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0901797
(5aR,5bS,7aS,10bR)-8-(1H-imidazol-1-yl)-3,5a,7a-trimethyl-4,5,5a,5b,6,7,7a,10b,11,12-decahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(3H)-one
   Show/Hide
C23H29N3O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0901799
(8R,9S,10R,13S,14S)-4,10,13-trimethyl-17-(pyridin-3-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
   Show/Hide
C25H31NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0902734
(3aS,5aS,5bR,8S,11aR,11bS)-3a,5b-dimethyl-3-(pyridin-3-yl)-3a,4,5,5a,5b,6,7,8,9,10,10a,11,11a,11b-tetradecahydro-1H-cyclopenta[a]cyclopropa[k]phenanthren-8-ol
   Show/Hide
C25H33NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0921841
(3R,8R,9S,10S,13S,14S)-17-(5-fluoropyridin-3-yl)-3,10,13-trimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
   Show/Hide
C25H34FNO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0928825
(5aS,5bS,7aS,10aS,10bR,12aS)-5a,7a-dimethyl-8-(4-methylpyridin-3-yl)-3,4,5,5a,5b,6,7,7a,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(1H)-one
   Show/Hide
C25H34N2O
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0930231
(8R,9S,10R,13S,14S)-17-(5-fluoropyridin-3-yl)-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
   Show/Hide
C25H30FNO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0940806
(8S,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-7,8,9,11,12,13,14,15-octahydrospiro[cyclopenta[a]phenanthrene-6,1'-cyclopropan]-3(10H)-one
   Show/Hide
C26H29NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0942318
(8R,9S,10R,13S,14S)-4,10,13-trimethyl-17-(pyridin-3-yl)-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
   Show/Hide
C25H35NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0946230
(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylene-17-(pyridin-3-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
   Show/Hide
C25H29NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0947210
(8R,9S,10R,13S)-10,13-dimethyl-17-(pyridin-3-yl)-6,7,8,9,10,11,12,13-octahydro-3H-cyclopenta[a]phenanthren-3-one
   Show/Hide
C24H25NO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS
CP0957267
(8S,9S,10R,13S,14S)-6-fluoro-10,13-dimethyl-17-(pyridin-3-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
   Show/Hide
C24H28FNO
 1
1
IC50 <= 15 nM
   TI
   LI
   LO
   TS