Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01549 , Mu-type opioid receptor
Gene Name OPRM1
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID P33535
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01549
 
Compound ID Compound Name Compound Formula
CP0393121
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(2-ethenylphenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
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C30H42N8O5
 1
1
EC50 = 0.012 nM
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CP0552003
2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetic acid
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C25H32N4O6
 1
1
EC50 = 0.012 nM
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CP0386948
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-(2-thiophen-3-ylphenyl)propan-2-yl]-5-(diaminomethylideneamino)pentanamide
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C32H42N8O5S
 1
1
EC50 = 0.04 nM
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CP0417239
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-[2-(2-methylprop-1-enyl)phenyl]-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
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C32H46N8O5
 1
1
EC50 = 0.1 nM
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CP0413476
(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-(2-phenylphenyl)propanamide
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C31H37N5O5
 1
1
EC50 = 0.12 nM
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CP0545964
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-[4-(trifluoromethyl)phenyl]propan-2-yl]-5-(diaminomethylideneamino)pentanamide
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C29H39F3N8O5
 1
1
EC50 = 0.12 nM
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CP0043301
(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide
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C26H35N5O6
 1
1
EC50 = 0.26 nM
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CP0548660
(S)-4-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-4-{(S)-1-[(S)-1-(carboxymethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-butyric acid
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C38H53N7O11
 1
1
EC50 = 16 nM
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CP0475884
(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-(2-thiophen-3-ylphenyl)propanamide
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C29H35N5O5S
 1
1
EC50 = 34.8 nM
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CP0054764
2-[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]guanidine
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C27H29N5O3
 3
1
Ki = 0.09 nM
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2
Ki = 0.5 nM
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3
Ki = 22.5 nM
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CP0050068
(1S,2S,13R,21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
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C26H26N2O3
 3
1
Ki = 0.36 nM
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2
Ki = 13.5 nM
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3
Ki = 34.4 nM
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CP0048724
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(oxidanyl)-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
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C20H23NO4
 3
1
Ki = 1.6 nM
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2
Ki = 2 nM
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3
Ki = 2.5 nM
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CP0038839
(4R,4aS,7aR,12bS)-3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
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C19H21NO4
 1
1
Ki = 2 nM
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CP0096567
7-(2'-spiroindanyl)oxymorphone
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C25H25NO4
 3
1
Ki = 3.9 nM
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2
Ki = 88.4 nM
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3
Ki = 154 nM
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CP0848535
5'-(Trimethylammonium)methyl-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan Iodide
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C30H36IN3O3
 1
1
Ki = 12.8 nM
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CP0048256
10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one
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C17H19NO4
 3
1
Ki = 17.4 nM
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2
Ki = 23.1 nM
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3
Ki = 26.2 nM
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CP0409091
5'-N-Biguanidino-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C28H31N7O3
 1
1
Ki = 21.5 nM
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CP0377768
2-[2-[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]ethyl]guanidine
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C29H33N5O3
 1
1
Ki = 33.4 nM
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CP0505602
5'-(Dimethylamino)methyl-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C29H33N3O3
 1
1
Ki = 36 nM
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CP0430310
5'-Amidinomethyl-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C28H30N4O3
 1
1
Ki = 40.8 nM
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CP0041449
C18130
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C40H43N3O6
 2
1
Ki = 49.7 nM
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2
Ki = 56.6 nM
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CP0405336
5'-Amidino-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C27H28N4O3
 1
1
Ki = 65.7 nM
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CP0381067
2-[[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]methyl]guanidine
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C28H31N5O3
 1
1
Ki = 66 nM
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CP0182209
5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C28H28N6O3
 1
1
Ki = 89.8 nM
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CP0396914
1-(2,4-dibromophenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
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C16H16Br2N2O
 1
1
Ki = 470 nM
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CP0396908
1-(2-bromo-4-chlorophenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
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C16H16BrClN2O
 1
1
Ki = 610 nM
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CP0553464
1-(2-bromo-4-methylphenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
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C17H19BrN2O
 1
1
Ki = 740 nM
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CP0402523
6,7-Dihydro-4,5alpha-epoxy-5'-guanidinyl-17-methyl-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C24H25N5O3
 1
1
Ki = 876 nM
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CP0396909
3-cyclopropyl-1-(2,4-dichlorophenyl)-6,6-dimethyl-5,7-dihydroindazol-4-one
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C18H18Cl2N2O
 1
1
Ki = 1300 nM
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CP0568893
1-(2,4-dimethylphenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
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C18H22N2O
 1
1
Ki = 3930 nM
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CP0396913
1-(2,4-dibromophenyl)-3,6,6-trimethyl-5,7-dihydro-4H-indazol-4-ol
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C16H18Br2N2O
 1
1
Ki > 100000 nM
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CP0530688
1-(4-chloro-2-methylphenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
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C17H19ClN2O
 1
1
Ki > 100000 nM
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