Brief Information of the Cell Line and Protein
Cell Line ID: CL000355 , MES-SA/Dx5
Synonyms
MES-SA/Dx-5
MES-SA-Dx5
MES-SA Dx5
MESSA/Dx5
MESSA-DX5
MESSA Dx5
MESSADX5
Dx5
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2598
Protein ID: PT01546 , ATP-dependent translocase ABCB1
Gene Name ABCB1
Organism Homo sapiens, Human
Protein Classification Transporter
Uniprot ID P08183
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000355  Protein ID: PT01546
 
Compound ID Compound Name Compound Formula
CP0559059
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-6-methyl-4-oxochromene-2-carboxamide
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C39H38N6O7
 1
1
EC50 = 4 nM
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CP0317641
Encequidar
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C38H36N6O7
 3
1
EC50 = 4.9 nM
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2
EC50 = 13 nM
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3
IC50 = 11 nM
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CP0557693
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-5-methoxy-4-oxochromene-2-carboxamide
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C39H38N6O8
 1
1
EC50 = 5.9 nM
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CP0564666
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-6-fluoro-4-oxochromene-2-carboxamide
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C38H35FN6O7
 1
1
EC50 = 7.5 nM
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CP0552262
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide
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C38H37N7O5
 2
1
EC50 = 14.5 nM
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2
EC50 = 75 nM
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CP0116921
1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]phenyl}-4,5-dimethoxy-2-(3-quinolylcarboxamido)benzamide
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C38H38N4O6
 1
1
EC50 = 16 nM
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CP0471412
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]thiophene-3-carboxamide
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C33H34N6O5S
 1
1
EC50 = 66.2 nM
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CP0471409
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]quinoline-8-carboxamide
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C38H37N7O5
 1
1
EC50 = 69.2 nM
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CP0471411
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-3,4-difluorobenzamide
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C35H34F2N6O5
 1
1
EC50 = 80.4 nM
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CP0557692
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]furan-3-carboxamide
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C33H34N6O6
 1
1
EC50 = 83.7 nM
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CP0552264
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]isoquinoline-3-carboxamide
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C38H37N7O5
 1
1
EC50 = 83.8 nM
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CP0554575
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]benzamide
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C35H36N6O5
 1
1
EC50 = 86.9 nM
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CP0559391
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]isoquinoline-4-carboxamide
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C38H37N7O5
 1
1
EC50 = 88.6 nM
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CP0471410
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]pyridine-3-carboxamide
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C34H35N7O5
 1
1
EC50 = 97.9 nM
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CP0554574
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]pyrazine-2-carboxamide
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C33H34N8O5
 1
1
EC50 = 97.9 nM
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CP0559057
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]quinoline-2-carboxamide
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C38H37N7O5
 1
1
EC50 = 109.9 nM
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CP0558082
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]naphthalene-2-carboxamide
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C39H38N6O5
 1
1
EC50 = 112.7 nM
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CP0552263
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxochromene-3-carboxamide
   Show/Hide
C38H36N6O7
 1
1
EC50 = 139.5 nM
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CP0559058
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]isoquinoline-1-carboxamide
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C38H37N7O5
 1
1
EC50 = 162 nM
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CP0569650
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-5-methoxy-4-(pyridin-3-ylmethoxy)phenyl]-4-oxochromene-2-carboxamide
   Show/Hide
C43H39N7O7
 1
1
IC50 = 8 nM
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CP0578197
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4-(pyridin-3-ylmethoxy)phenyl]-4-oxochromene-2-carboxamide
   Show/Hide
C42H37N7O6
 1
1
IC50 = 14 nM
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CP0488478
N-[2-[2-[4-[2-(6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl)ethyl]phenyl]tetrazol-5-yl]-5-methoxy-4-phenylmethoxyphenyl]-4-oxochromene-2-carboxamide
   Show/Hide
C39H34N8O5
 1
1
IC50 = 18 nM
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CP0552673
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4-(pyridin-4-ylmethoxy)phenyl]-4-oxochromene-2-carboxamide
   Show/Hide
C42H37N7O6
 1
1
IC50 = 35 nM
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CP0552803
N-[2-[2-[4-[2-(3,4-dihydro-1H-2,6-naphthyridin-2-yl)ethyl]phenyl]tetrazol-5-yl]-5-methoxy-4-phenylmethoxyphenyl]quinoline-3-carboxamide
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C41H36N8O3
 1
1
IC50 = 39 nM
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CP0577812
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4-pyridin-3-yloxyphenyl]-4-oxochromene-2-carboxamide
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C41H35N7O6
 1
1
IC50 = 39 nM
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CP0570046
N-[2-[2-[4-[2-(3,4-dihydro-1H-2,6-naphthyridin-2-yl)ethyl]phenyl]tetrazol-5-yl]-5-methoxy-4-phenylmethoxyphenyl]-4-oxochromene-2-carboxamide
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C41H35N7O5
 1
1
IC50 = 41 nM
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CP0554131
N-[2-[2-[4-[2-(3,4-dihydro-1H-2,6-naphthyridin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxochromene-2-carboxamide
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C35H31N7O5
 1
1
IC50 = 49 nM
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CP0488477
N-[2-[2-[4-[2-(3,4-dihydro-1H-2,7-naphthyridin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxochromene-2-carboxamide
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C35H31N7O5
 1
1
IC50 = 50 nM
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CP0577247
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-5-methoxy-4-phenylmethoxyphenyl]-4-oxochromene-2-carboxamide
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C44H40N6O7
 1
1
IC50 = 61 nM
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CP0552801
6-bromo-N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxochromene-2-carboxamide
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C38H35BrN6O7
 1
1
IC50 = 91 nM
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CP0576285
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-pyridin-4-ylbenzamide
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C40H39N7O5
 1
1
IC50 = 94 nM
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CP0554125
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4-(2-pyridin-3-ylethoxy)phenyl]-4-oxochromene-2-carboxamide
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C43H39N7O6
 1
1
IC50 = 210 nM
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CP0544325
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-pyridin-3-ylbenzamide
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C40H39N7O5
 1
1
IC50 = 222 nM
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CP0575203
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-imidazol-1-ylbenzamide
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C38H38N8O5
 1
1
IC50 = 495 nM
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CP0577246
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4-pyridin-4-yloxyphenyl]-4-oxochromene-2-carboxamide
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C41H35N7O6
 1
1
IC50 = 993 nM
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CP0096660
1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
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C26H28Cl2N4O4
 1
1
IC50 = 1058 nM
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CP0036382
CAS_52-53-9
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C27H38N2O4
 1
1
IC50 = 4780 nM
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CP0069095
(S) Verapamil
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C27H38N2O4
 1
1
IC50 = 5330 nM
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CP0067890
(R)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile
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C27H38N2O4
 1
1
IC50 = 5520 nM
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CP0398503
(1S)-1-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-4,5-dimethoxy-2,3-dihydroindene-1-carbonitrile
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C26H34N2O4
 1
1
IC50 = 6630 nM
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CP0939907
KR30031 (racemic)
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C26H34N2O4
 1
1
IC50 = 7630 nM
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CP0398504
(1R)-1-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-4,5-dimethoxy-2,3-dihydroindene-1-carbonitrile
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C26H34N2O4
 1
1
IC50 = 7650 nM
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CP0549823
N-[2-[2-[4-[2-(6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxochromene-2-carboxamide
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C33H30N8O5
 1
1
IC50 > 1280 nM
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CP0551411
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-6-imidazol-1-yl-4-oxochromene-2-carboxamide
   Show/Hide
C41H38N8O7
 1
1
IC50 > 1280 nM
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CP0552768
N-[2-[2-[4-[2-(6-imidazol-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxochromene-2-carboxamide
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C39H34N8O5
 1
1
IC50 > 1280 nM
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CP0552802
N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-6-pyridin-4-ylchromene-2-carboxamide
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C43H39N7O7
 1
1
IC50 > 1280 nM
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CP0579662
N-[2-[2-[4-[2-(7-imidazol-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxochromene-2-carboxamide
   Show/Hide
C39H34N8O5
 1
1
IC50 > 1280 nM
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