Brief Information of the Cell Line and Protein
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Synonyms
SF21
Sf-21
SF-21
IPLB-SF-21-AE
IPLB-Sf21-AE
IPLB-SF21-AE
IPLB-SF 21AE
IPLB-Sf21AE
IPLB-SF21AE
IPLB-SF-21
IPLB-Sf-21
IPLB-SF 21
IPLB-Sf21
IPLB-SF21
Category Spontaneously immortalized cell line
Organism
Spodoptera frugiperda (Fall armyworm)
Cellosaurus ID
CVCL_0518
Protein ID: PT01390 , BDNF/NT-3 growth factors receptor
 Protein Info 
Gene Name NTRK2
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q16620
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000012
 Cell Line Info 
 Protein ID: PT01390
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0559176
 Compound Info 
(3R)-N-[5-[(2S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide
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C21H22F2N6O2
  1
1
IC50 = 4.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0494238
 Compound Info 
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
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C26H30F2N6O
  1
1
IC50 = 23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0555714
 Compound Info 
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-morpholin-4-ylbenzamide
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C25H27F2N5O2
  1
1
IC50 = 27 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419166
 Compound Info 
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
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C26H30F2N6O
  1
1
IC50 = 28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0553600
 Compound Info 
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-morpholin-4-ylbenzamide
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C25H27F2N5O2
  1
1
IC50 = 35 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419168
 Compound Info 
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-morpholin-4-ylbenzamide
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C25H27F2N5O2
  1
1
IC50 = 170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0555715
 Compound Info 
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-(4-methylpiperazin-1-yl)benzamide
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C26H30F2N6O
  1
1
IC50 = 190 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0542725
 Compound Info 
N-(5-tert-butyl-2-phenylpyrazol-3-yl)-2-(1-phenyltetrazol-5-yl)sulfanylacetamide
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C22H23N7OS
  1
1
Kd = 1.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS