8-(3,5-dichloroanilino)-4-methyl-5-methylsulfonyl-2,6,7,11-tetrazatricyclo[7.4.0.03,7]trideca-1,3,5,8-tetraen-10-one

8-(3-methoxyanilino)-4-methyl-5-methylsulfonyl-2,6,7,11-tetrazatricyclo[7.4.0.03,7]trideca-1,3,5,8-tetraen-10-one

7-(3,5-dichloroanilino)-2-[3-(dimethylcarbamoyl)phenyl]sulfonyl-3-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

8-(3,5-dichloroanilino)-4-methyl-5-methylsulfanyl-2,6,7,11-tetrazatricyclo[7.4.0.03,7]trideca-1,3,5,8-tetraen-10-one

2-[3-(dimethylcarbamoyl)phenyl]sulfonyl-7-(3-methoxyanilino)-3-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

N-benzyl-1-ethyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxamide

2-(benzenesulfonyl)-7-(3-methoxyanilino)-3-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

7-(3-methoxyanilino)-2-methylsulfonyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-6-carboxamide

7-(3,5-dichloroanilino)-2-methylsulfonyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-6-carboxamide

7-(3,5-dichloroanilino)-3-methyl-2-methylsulfonylpyrazolo[1,5-a]pyrimidine-6-carboxamide

2-(benzenesulfonyl)-7-(3,5-dichloroanilino)-3-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

N-(cyclohexylmethyl)-1-ethyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxamide

ethyl 4-(cyclohexylamino)-1-ethylpyrazolo[3,4-b]pyridine-5-carboxylate

3-[4-[[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino]phenyl]propan-1-ol

1-ethyl-N-(4-fluorophenyl)-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxamide

4-(3,4-dimethoxyphenyl)-N-pyridin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide

ethyl 1-ethyl-4-(2-methylpropylamino)pyrazolo[3,4-b]pyridine-5-carboxylate

7-(3,5-dichloroanilino)-3-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

1-ethyl-N-(2-ethylbutyl)-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxamide

(S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

2-[4-[[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino]phenyl]ethanol

1-ethyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxamide

7-(3-methoxyanilino)-3-methyl-2-methylsulfonylpyrazolo[1,5-a]pyrimidine-6-carboxamide

N-(3,4-dimethoxyphenyl)-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide

3-ethyl-7-(3-methoxyanilino)pyrazolo[1,5-a]pyrimidine-6-carboxamide

2-[4-[[2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl]amino]phenyl]acetamide

N-(3,5-dichloropyridin-4-yl)-4-(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamide

4-[[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino]benzamide

2-[4-[[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino]phenyl]acetamide

N-benzyl-1-ethyl-N-methyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxamide

N-cyclopentyl-1-ethyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxamide

2-[4-[[2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl]amino]phenyl]ethanol

2-[4-[2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl]oxyphenyl]ethanol

N-[2-(3,4-dimethoxyphenyl)ethyl]-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide

N,4-bis(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamide

ethyl 4-(cyclopentylamino)-1-ethylpyrazolo[3,4-b]pyridine-5-carboxylate

N-(3,4-dimethoxyphenyl)-4-morpholin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide

N-(3,5-dichloropyridin-4-yl)-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide

N-[(2,4-dimethoxyphenyl)methyl]-4-morpholin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide

4-(3,4-dimethoxyphenyl)-2-methylsulfanyl-N-pyridin-4-ylpyrimidine-5-carboxamide

2-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]-N-methylacetamide

N-cyclopropyl-1-ethyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxamide

ethyl 4-(oxan-4-ylamino)-1-propylpyrazolo[3,4-b]pyridine-5-carboxylate

[4-[[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino]phenyl]methanol

(R,S)-Rolipram

azetidin-1-yl-[3-(3,4-dichlorophenyl)imidazo[4,5-b]pyridin-2-yl]methanone

N-(1-acetylpiperidin-4-yl)-1-ethyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxamide

2-[4-[[2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl]methyl]phenyl]-N-(2-hydroxyethyl)acetamide

2-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]acetamide

2-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]methyl]phenyl]acetamide

[3-(3,4-dichlorophenyl)imidazo[4,5-b]pyridin-2-yl]-(3,3-difluoroazetidin-1-yl)methanone

N-[2-(3,4-dimethoxyphenyl)ethyl]-4-morpholin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide

ethyl 1-(2-hydroxyethyl)-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxylate

ethyl 4-anilino-1-ethylpyrazolo[3,4-b]pyridine-5-carboxylate

[1-ethyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridin-5-yl]-pyrrolidin-1-ylmethanone

7-(3-methoxyanilino)-3-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

N-[2-(1H-indol-3-yl)ethyl]-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide

3-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]propanamide

N-(2-chlorophenyl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide

N-(3,5-dichloropyridin-4-yl)-4-(3,4-dimethoxyphenyl)-2-methylsulfanylpyrimidine-5-carboxamide

N-cyclopropyl-4-(3,4-dimethoxyphenyl)-2-methylsulfonylpyrimidine-5-carboxamide

4-(3,4-dimethoxyphenyl)-N-(2-morpholin-4-ylethyl)-2-(trifluoromethyl)pyrimidine-5-carboxamide

4-Butylamino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

ethyl 4-(oxan-4-ylamino)-1-propan-2-ylpyrazolo[3,4-b]pyridine-5-carboxylate

ethyl 2-[3-(3-chloroquinoxalin-2-yl)-5-methoxyindol-1-yl]acetate

[1-(4-chloro-3,5-difluorophenyl)pyrrolo[2,3-b]pyridin-2-yl]-(3-fluoroazetidin-1-yl)methanone

4-(3,4-dimethoxyphenyl)-N-[2,6-di(propan-2-yl)phenyl]-2-(trifluoromethyl)pyrimidine-5-carboxamide

2-[4-[[2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl]methyl]phenyl]acetamide

[3-(3,4-dichlorophenyl)imidazo[4,5-b]pyridin-2-yl]-(3-fluoroazetidin-1-yl)methanone

N-[2-(3,4-dimethoxyphenyl)ethyl]-4-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylsulfanylpyrimidine-5-carboxamide

4-(3,4-dimethoxyphenyl)-2-methylsulfanyl-N-(oxan-4-yl)pyrimidine-5-carboxamide

4-[[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino]benzoic acid

ethyl 1-methyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxylate

ethyl 1-ethyl-4-[methyl(oxan-4-yl)amino]pyrazolo[3,4-b]pyridine-5-carboxylate

N-cyclopropyl-4-(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamide

4-(3,4-dimethoxyphenyl)-N-(oxan-4-yl)-2-(trifluoromethyl)pyrimidine-5-carboxamide

ethyl 1-ethyl-4-[(4-fluorophenyl)methylamino]pyrazolo[3,4-b]pyridine-5-carboxylate

N-[[3-(3-fluorophenyl)-4-methoxyphenyl]methyl]pyridin-3-amine

2-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]-N,N-dimethylacetamide

N-(4-fluorophenyl)-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide

2-chloro-3-(5-methoxy-1-prop-2-enylindol-3-yl)quinoxaline

[1-(3,5-difluoro-4-methoxyphenyl)pyrrolo[2,3-b]pyridin-2-yl]-(3-fluoroazetidin-1-yl)methanone

2,6-difluoro-4-[2-(3-fluoroazetidine-1-carbonyl)pyrrolo[2,3-b]pyridin-1-yl]benzonitrile

[3-(3,4-dichlorophenyl)imidazo[4,5-b]pyridin-2-yl]-[3-(trifluoromethyl)azetidin-1-yl]methanone

2-chloro-3-(5-methoxy-1-propan-2-ylindol-3-yl)quinoxaline

N-cyclopropyl-4-(3,4-dimethoxyphenyl)-2-methylsulfanylpyrimidine-5-carboxamide

1-(3-chloro-4-methylphenyl)-N-cyclopropylpyrrolo[2,3-b]pyridine-2-carboxamide

[1-(5-chloro-6-methoxypyridin-3-yl)pyrrolo[2,3-b]pyridin-2-yl]-(3-fluoroazetidin-1-yl)methanone

4-(3,4-dimethoxyphenyl)-2-methylsulfonyl-N-(oxan-4-yl)pyrimidine-5-carboxamide

2-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]ethanol

2-[4-[[2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl]methyl]phenyl]ethanol

3-(3,4-dichlorophenyl)-N-(3-fluorocyclobutyl)imidazo[4,5-b]pyridine-2-carboxamide

[1-(4-chloro-3-fluorophenyl)pyrrolo[2,3-b]pyridin-2-yl]-(3-fluoroazetidin-1-yl)methanone

N-Cyclopropyl-3-(3,4-dichlorophenyl)-3H-imidazo[4,5-b]pyridine-2-carboxamide

ethyl 1-ethyl-4-pyrrolidin-1-ylpyrazolo[3,4-b]pyridine-5-carboxylate

N,4-bis(3,4-dimethoxyphenyl)-2-methylsulfanylpyrimidine-5-carboxamide

N-[[4-methoxy-3-(3-methoxyphenyl)phenyl]methyl]pyridin-3-amine

2-[4-[[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino]phenyl]acetic acid

N-[[7-(3-fluorophenyl)-2,3-dihydro-1-benzofuran-5-yl]methyl]pyridin-3-amine

3-(3-Chloro-4-methylphenyl)-N-cyclopropyl-3H-imidazo[4,5-b]pyridine-2-carboxamide

4-(3,4-dimethoxyphenyl)-N,N-diethyl-2-(trifluoromethyl)pyrimidine-5-carboxamide

N-(3,4-dimethoxyphenyl)-4-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylsulfanylpyrimidine-5-carboxamide

[1-(3-chloro-4-methylphenyl)pyrrolo[2,3-b]pyridin-2-yl]-(3-fluoroazetidin-1-yl)methanone

N-[[7-(3-chlorophenyl)-2,3-dihydro-1-benzofuran-5-yl]methyl]pyridin-3-amine

2-[4-[2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl]oxyphenyl]acetamide

1-(4-chloro-3-fluorophenyl)-N-cyclopropylpyrrolo[2,3-b]pyridine-2-carboxamide

6-azaspiro[3.4]octan-6-yl-[3-(3,4-dichlorophenyl)imidazo[4,5-b]pyridin-2-yl]methanone

(3-fluoroazetidin-1-yl)-[1-(2-fluoropyridin-4-yl)pyrrolo[2,3-b]pyridin-2-yl]methanone

ethyl 1-ethyl-4-(4-methoxyanilino)pyrazolo[3,4-b]pyridine-5-carboxylate

2-(1-butan-2-yl-5-methoxyindol-3-yl)-3-chloroquinoxaline

2-[4-[[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino]phenyl]propanoic acid

10-[(5-bromo-1-methylsulfonylindol-2-yl)methyl]-2-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-b][1,5]benzodiazepine

N-cyclobutyl-3-(3,4-dichlorophenyl)imidazo[4,5-b]pyridine-2-carboxamide

1-(4-chloro-3-fluorophenyl)-N-cyclobutylpyrrolo[2,3-b]pyridine-2-carboxamide

1-(4-chloro-3,5-difluorophenyl)-N-cyclobutylpyrrolo[2,3-b]pyridine-2-carboxamide

N-[2-[(5-fluoro-1-methylsulfonylindol-2-yl)methoxymethyl]phenyl]-2,3-dimethylaniline

4-[1,3-dimethyl-2,6-dioxo-8-(2-phenylethylamino)purin-7-yl]-N-[(E)-(2,3,4-trihydroxyphenyl)methylideneamino]butanamide

1-(4-chloro-3,5-difluorophenyl)-N-cyclopropylpyrrolo[2,3-b]pyridine-2-carboxamide

1-(4-cyano-3,5-difluorophenyl)-N-cyclopropylpyrrolo[2,3-b]pyridine-2-carboxamide

2-[3-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]ethanol

2-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]acetic acid

2,3-dimethyl-N-[2-[(1-methylsulfonylindol-2-yl)methoxymethyl]phenyl]aniline

4-[1,3-dimethyl-2,6-dioxo-8-(pyridin-2-ylmethylamino)purin-7-yl]-N-[(E)-(2,3,4-trihydroxyphenyl)methylideneamino]butanamide

1-(4-cyano-3,5-difluorophenyl)-N-cyclobutylpyrrolo[2,3-b]pyridine-2-carboxamide

4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxopurin-7-yl]-N-[(E)-(2,3,4-trihydroxyphenyl)methylideneamino]butanamide

7-anilino-3-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

2-(5-methoxy-1-prop-2-enylindol-3-yl)pyridine-3-carbonitrile

ethyl 4-(oxan-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

2-[4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl]phenyl]acetic acid

N-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]pyridin-3-amine

1-(3-chloro-4-methylphenyl)-N-cyclobutylpyrrolo[2,3-b]pyridine-2-carboxamide

[1-(3,4-dichlorophenyl)benzimidazol-2-yl]-(3-fluoroazetidin-1-yl)methanone

ethyl 4-benzamido-1-ethylpyrazolo[3,4-b]pyridine-5-carboxylate

1-(4-chlorophenyl)-N-cyclopropylpyrrolo[2,3-b]pyridine-2-carboxamide

ethyl 4-(oxan-4-ylamino)-1-phenylpyrazolo[3,4-b]pyridine-5-carboxylate

2-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]-methylamino]phenyl]acetamide

4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]morpholine

4-[[3-(3-fluorophenyl)-4-methoxyphenyl]methyl]morpholine

2-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]sulfonyl]phenyl]acetamide

methyl (E)-3-[3-(3-chloroquinoxalin-2-yl)-1H-indol-2-yl]prop-2-enoate

ethyl 1-benzyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxylate

4-[[3-(3-chlorophenyl)-4-(difluoromethoxy)phenyl]methyl]morpholine

2,3-dimethyl-N-[2-[(5-methyl-1-methylsulfonylindol-2-yl)methoxymethyl]phenyl]aniline

N-cyclopropyl-3-(3,4-dichlorophenyl)pyrazolo[1,5-a]pyridine-2-carboxamide

N-[(E)-(2,4-dihydroxyphenyl)methylideneamino]-4-[8-(furan-2-ylmethylamino)-1,3-dimethyl-2,6-dioxopurin-7-yl]butanamide

N-[2-[(5-chloro-1-methylsulfonylindol-2-yl)methoxymethyl]phenyl]-2,3-dimethylaniline

2-chloro-3-(1-prop-2-enylindol-3-yl)quinoxaline

1-(4-chlorophenyl)-N-cyclobutylpyrrolo[2,3-b]pyridine-2-carboxamide

ethyl 1-(3-ethoxy-3-oxopropyl)-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxylate

4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxopurin-7-yl]-N-[(E)-(2,4-dihydroxyphenyl)methylideneamino]butanamide

ethyl (E)-3-[3-(3-chloroquinoxalin-2-yl)-5-methoxy-1-propan-2-ylindol-2-yl]prop-2-enoate

methyl (E)-3-[3-(3-chloroquinoxalin-2-yl)-5-methoxy-1-propan-2-ylindol-2-yl]prop-2-enoate

4-[8-(furan-2-ylmethylamino)-1,3-dimethyl-2,6-dioxopurin-7-yl]-N-[(E)-(2,3,4-trihydroxyphenyl)methylideneamino]butanamide

4-[1,3-dimethyl-2,6-dioxo-8-(pyridin-2-ylmethylamino)purin-7-yl]-N-[(E)-(2-hydroxyphenyl)methylideneamino]butanamide

4-(8-ethoxy-1,3-dimethyl-2,6-dioxopurin-7-yl)-N-[(E)-(2-hydroxyphenyl)methylideneamino]butanamide

1-(3-chloro-4-methylphenyl)-N-(3-fluorocyclobutyl)pyrrolo[2,3-b]pyridine-2-carboxamide

2-(5-bromo-1-propan-2-ylindol-3-yl)-3-chloroquinoxaline

7-(3-methoxyanilino)-N,3-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxamide

N-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]-4-fluoroaniline

1-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]-3-methylpiperidine

(2S)-2-[[3-(3-chlorophenyl)-4-methoxyphenyl]methylamino]-3-phenylpropanoic acid

N-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]pyridin-2-amine

4-chloro-N-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]aniline

methyl 4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methylamino]benzoate

1-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]piperidin-4-ol

N-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]-6-methoxypyridin-3-amine

N-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]-4-methoxyaniline

N-[[3-(3-chlorophenyl)-4-(difluoromethoxy)phenyl]methyl]pyridin-3-amine

[4-[3-(3-fluoro-4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone