Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01205 , Prostaglandin E2 receptor EP1 subtype
Gene Name PTGER1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P34995
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01205
 
Compound ID Compound Name Compound Formula
CP0938030
7-((1R,2S,3R,5R)-5-chloro-2-(2,3-dihydro-1H-inden-5-yl)-3-hydroxycyclopentyl)heptanoic acid
   Show/Hide
C21H29ClO3
 1
1
EC50 = 221 nM
   TI
   LI
   LO
   TS
CP0866395
7-((1R,2S,3R)-3-hydroxy-5-oxo-2-p-tolylcyclopentyl)heptanoic acid
   Show/Hide
C19H26O4
 1
1
EC50 = 1873 nM
   TI
   LI
   LO
   TS
CP0437306
7-[2-(3-hydroxyoctyl)-6-oxopyridin-1-yl]heptanoic acid
   Show/Hide
C20H33NO4
 1
1
EC50 = 2350 nM
   TI
   LI
   LO
   TS
CP0866241
5-(3-{(S)-1-[4-(1-Hydroxy-heptyl)-phenyl]-5-oxo-pyrrolidin-2-yl}-propyl)-thiophene-2-carboxylic acid
   Show/Hide
C25H33NO4S
 1
1
EC50 = 6952 nM
   TI
   LI
   LO
   TS
CP0847242
5-[(R)-1-(4-tert-Butyl-phenyl)-5-oxo-pyrrolidin-2-ylmethoxymethyl]-thiophene-2-carboxylic acid
   Show/Hide
C21H25NO4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0866254
7-((1R,2S,3R,5R)-2-(4-tert-butylphenyl)-5-chloro-3-hydroxycyclopentyl)hept-5-enoic acid
   Show/Hide
C22H31ClO3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0866304
7-((1R,2S,3R)-2-(4-tert-butylphenyl)-3-hydroxy-5-oxocyclopentyl)hept-5-enoic acid
   Show/Hide
C22H30O4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0866433
7-((1R,2S,3R,5R)-2-(4-tert-butylphenyl)-5-chloro-3-hydroxycyclopentyl)heptanoic acid
   Show/Hide
C22H33ClO3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0866744
7-[(S)-1-(4-tert-Butyl-phenyl)-5-oxo-pyrrolidin-2-yl]-heptanoic acid
   Show/Hide
C21H31NO3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0924067
7-((1R,2S,3R)-2-(4-tert-butylphenyl)-3-hydroxy-5-oxocyclopentyl)heptanoic acid
   Show/Hide
C22H32O4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0420325
4-[2-[3,5-dichloro-2-[(E)-3-hydroxyoct-1-enyl]-6-oxopyridin-1-yl]ethyl]benzoic acid
   Show/Hide
C22H25Cl2NO4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0423796
4-[2-[3,5-dichloro-2-(3-hydroxyoctyl)-6-oxopyridin-1-yl]ethyl]benzoic acid
   Show/Hide
C22H27Cl2NO4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0437308
4-[2-[3,5-dichloro-2-[(E)-3-hydroxy-3-methyloct-1-enyl]-6-oxopyridin-1-yl]ethyl]benzoic acid
   Show/Hide
C23H27Cl2NO4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0487510
7-[3,5-dibromo-2-[(E)-3-hydroxyoct-1-enyl]-6-oxopyridin-1-yl]heptanoic acid
   Show/Hide
C20H29Br2NO4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0525833
7-[3,5-dichloro-2-[(E)-3-hydroxyoct-1-enyl]-6-oxopyridin-1-yl]heptanoic acid
   Show/Hide
C20H29Cl2NO4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0272414
US11149018, Example 34
   Show/Hide
C26H27BrClN3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0432637
5-{3-[(S)-2-(4-biphenyl-3-yl-3-hydroxy-butyl)-5-oxo-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid
   Show/Hide
C28H31NO4S
 1
1
IC50 = 18550 nM
   TI
   LI
   LO
   TS
CP0379520
5-(3-((S)-2-(4-(4-chlorophenyl)-3-hydroxybutyl)-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylic acid
   Show/Hide
C22H26ClNO4S
 1
1
IC50 > 3200 nM
   TI
   LI
   LO
   TS
CP0393919
4-(3-(2-(3-hydroxy-4-phenylbutyl)-5-oxopyrrolidin-1-yl)propyl)benzoic acid
   Show/Hide
C24H29NO4
 1
1
IC50 > 3200 nM
   TI
   LI
   LO
   TS
CP0419598
4-(3-(2-(4-(3-chlorophenyl)-3-hydroxybutyl)-5-oxopyrrolidin-1-yl)propyl)benzoic acid
   Show/Hide
C24H28ClNO4
 1
1
IC50 > 3200 nM
   TI
   LI
   LO
   TS
CP0435419
7-((S)-2-(3-hydroxy-4-phenylbutyl)-5-oxopyrrolidin-1-yl)heptanoic acid
   Show/Hide
C21H31NO4
 1
1
IC50 > 3200 nM
   TI
   LI
   LO
   TS
CP0436870
4-(3-(2-(4-(4-fluorophenyl)-3-hydroxybutyl)-5-oxopyrrolidin-1-yl)propyl)benzoic acid
   Show/Hide
C24H28FNO4
 1
1
IC50 > 3200 nM
   TI
   LI
   LO
   TS
CP0439427
7-((S)-2-((R)-3-hydroxy-4-(3-(methoxymethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)heptanoic acid
   Show/Hide
C23H35NO5
 1
1
IC50 > 3200 nM
   TI
   LI
   LO
   TS
CP0442359
7-((S)-2-(3-hydroxy-4-(3-phenoxyphenyl)butyl)-5-oxopyrrolidin-1-yl)heptanoic acid
   Show/Hide
C27H35NO5
 1
1
IC50 > 3200 nM
   TI
   LI
   LO
   TS
CP0055947
(15S)-prostaglandin E2
   Show/Hide
C20H32O5
 1
1
Ki = 9.1 nM
   TI
   LI
   LO
   TS
CP0441655
4-[3-(2-Benzyloxy-phenyl)-propyl]-benzoic acid
   Show/Hide
C23H22O3
 1
1
Ki = 230 nM
   TI
   LI
   LO
   TS
CP0404532
3-[2''-(2,6-Dichloro-benzyloxy)-[1,1';3',1'']terphenyl-2-yl]-propionic acid
   Show/Hide
C28H22Cl2O3
 1
1
Ki = 1100 nM
   TI
   LI
   LO
   TS
CP0343798
2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid
   Show/Hide
C21H19ClFNO4S
 1
1
Ki = 1160 nM
   TI
   LI
   LO
   TS
CP0404585
3-[2-[3-(2-phenylmethoxyphenyl)phenyl]phenyl]-N-thiophen-2-ylsulfonylpropanamide
   Show/Hide
C32H27NO4S2
 1
1
Ki = 2600 nM
   TI
   LI
   LO
   TS
CP0374187
2-[(3R)-5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid
   Show/Hide
C20H16BrClFNO2
 1
1
Ki = 4400 nM
   TI
   LI
   LO
   TS
CP0160939
(E)-3-[2-(3,4-dichlorophenyl)phenyl]-N-thiophen-2-ylsulfonylprop-2-enamide
   Show/Hide
C19H13Cl2NO3S2
 1
1
Ki = 8100 nM
   TI
   LI
   LO
   TS
CP0406374
3-(2''-Benzyloxy-[1,1';3',1'']terphenyl-2-yl)-2-methyl-propionic acid
   Show/Hide
C29H26O3
 1
1
Ki = 8300 nM
   TI
   LI
   LO
   TS
CP0436538
3-(2-Benzyloxy-[1,1';3',1'']terphenyl-2''-yl)-propionic acid
   Show/Hide
C28H24O3
 1
1
Ki = 8300 nM
   TI
   LI
   LO
   TS
CP0441093
(2''-Benzyloxy-[1,1';3',1'']terphenyl-2-yl)-acetic acid
   Show/Hide
C27H22O3
 1
1
Ki = 9300 nM
   TI
   LI
   LO
   TS
CP0404232
3-(2-Phenoxymethyl-[1,1';3',1'']terphenyl-2''-yl)-propionic acid
   Show/Hide
C28H24O3
 1
1
Ki = 9500 nM
   TI
   LI
   LO
   TS
CP0112283
APD-811
   Show/Hide
C23H26ClNO5
 1
1
Ki = 9600 nM
   TI
   LI
   LO
   TS
CP0415118
(E)-3-(3',4'-Dichloro-biphenyl-2-yl)-acrylic acid
   Show/Hide
C15H10Cl2O2
 1
1
Ki = 10000 nM
   TI
   LI
   LO
   TS
CP0080235
4-(2-((R)-2-((S)-3-hydroxyhept-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoate
   Show/Hide
C20H27NO4
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0452766
4-(2-((R)-2-(4-methylocta-1,3-dienyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid
   Show/Hide
C22H29NO3
 1
1
Ki = 10000 nM
   TI
   LI
   LO
   TS
CP0464527
4-(2-((R)-2-(4-methylocta-1,3-dienyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid
   Show/Hide
C22H29NO3
 1
1
Ki = 10000 nM
   TI
   LI
   LO
   TS
CP0437614
4-(2-Benzyloxy-[1,1';3',1'']terphenyl-2''-yl)-butyric acid
   Show/Hide
C29H26O3
 1
1
Ki = 11900 nM
   TI
   LI
   LO
   TS
CP0277044
(E)-3-{2-[(E)-3-(2-Benzyloxy-3-methyl-phenyl)-allyl]-phenyl}-acrylic acid
   Show/Hide
C26H24O3
 1
1
Ki = 12000 nM
   TI
   LI
   LO
   TS
CP0430206
3-{2-[5-(2-Benzyloxy-phenyl)-thiophen-3-yl]-phenyl}-2-methyl-propionic acid
   Show/Hide
C27H24O3S
 1
1
Ki = 13000 nM
   TI
   LI
   LO
   TS
CP0424293
3-{2-[4-(2-Benzyloxy-phenyl)-thiophen-2-yl]-phenyl}-propionic acid
   Show/Hide
C26H22O3S
 1
1
Ki = 17500 nM
   TI
   LI
   LO
   TS
CP0381724
3-{2-[5-(2-Benzyloxy-phenyl)-thiophen-3-yl]-phenyl}-propionic acid
   Show/Hide
C26H22O3S
 1
1
Ki = 17800 nM
   TI
   LI
   LO
   TS
CP0041889
2-((R)-4-(4-chlorobenzyl)-5-(1-hydroxyethyl)-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid
   Show/Hide
C23H24ClNO5S
 1
1
Ki > 20000 nM
   TI
   LI
   LO
   TS
CP0108218
(R)-2-(4-(4-chlorobenzyl)-5-acetyl-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid
   Show/Hide
C23H22ClNO5S
 1
1
Ki > 20000 nM
   TI
   LI
   LO
   TS
CP0466770
3-{2-[5-(2-Benzyloxy-phenyl)-thiophen-2-yl]-phenyl}-propionic acid
   Show/Hide
C26H22O3S
 1
1
Ki = 27000 nM
   TI
   LI
   LO
   TS
CP0381706
3-[1,1';3',1'']Terphenyl-2-yl-propionic acid
   Show/Hide
C21H18O2
 1
1
Ki = 34000 nM
   TI
   LI
   LO
   TS
CP0372972
3-{2-[5-(2-Benzyloxy-phenyl)-thiophen-3-yl]-phenyl}-butyric acid
   Show/Hide
C27H24O3S
 1
1
Ki = 35000 nM
   TI
   LI
   LO
   TS
CP0181173
2-{2-[5-(2-Benzyloxy-phenyl)-thiophen-3-yl]-phenyl}-cyclopropanecarboxylic acid
   Show/Hide
C27H22O3S
 1
1
Ki = 48000 nM
   TI
   LI
   LO
   TS
CP0496137
(E)-3-(2-Benzyloxy-[1,1';3',1'']terphenyl-2''-yl)-acrylic acid
   Show/Hide
C28H22O3
 1
1
Ki = 72000 nM
   TI
   LI
   LO
   TS
CP0466746
2-[2-[5-(2-phenylmethoxyphenyl)thiophen-3-yl]anilino]acetic acid
   Show/Hide
C25H21NO3S
 1
1
Ki = 85000 nM
   TI
   LI
   LO
   TS
CP0404233
3-(4''-Benzyloxy-[1,1';3',1'']terphenyl-2-yl)-propionic acid
   Show/Hide
C28H24O3
 1
1
Ki > 97000 nM
   TI
   LI
   LO
   TS
CP0393748
N-[[4-(5,9-diethoxy-6-oxo-8H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylphenyl]methylsulfonyl]-2-(2-methoxyphenyl)acetamide
   Show/Hide
C32H33N3O7S
 1
1
Ki > 7000 nM
   TI
   LI
   LO
   TS
CP0372074
2-[(3R)-5-acetyl-4-[(4-chlorophenyl)methyl]-7-fluoro-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid
   Show/Hide
C22H19ClFNO3
 1
1
Ki > 9000 nM
   TI
   LI
   LO
   TS
CP0422463
1-(2,6-dimethoxyphenyl)-N-[[3-methyl-4-[6-oxo-5,9-bis(2,2,2-trifluoroethoxy)-8H-pyrrolo[3,4-g]quinolin-7-yl]phenyl]methylsulfonyl]cyclopropane-1-carboxamide
   Show/Hide
C35H31F6N3O8S
 1
1
Ki > 9000 nM
   TI
   LI
   LO
   TS