| Compound ID |
Compound Name |
Compound Formula |
|
CP0967056
|
methyl(3R,5S)-3,5-dimethyl-4-[3-[6-[(3R)-3-methylpiperazin-1-yl]-3-pyridyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]piperazine-1-carboxylate
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|
C23H31N9O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0950697
|
[(3R,5S)-3,5-dimethyl-4-[3-[6-[(3R)-3-methylpiperazin-1-yl]-3-pyridyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]piperazin-1-yl]-pyrrolidin-1-yl-methanone
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|
C26H36N10O
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0965080
|
methyl(3R,5S)-3,5-dimethyl-4-[3-[6-(4-methylpiperazin-1-yl)-3-pyridyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]piperazine-1-carboxylate
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|
C23H31N9O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0970051
|
methyl(3R,5S)-3,5-dimethyl-4-[3-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]piperazine-1-carboxylate
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|
C24H32N8O2
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0579477
|
8-amino-2-cyclobutyl-5-(1-piperidin-4-ylpyrazol-4-yl)-3,4-dihydro-2,7-naphthyridin-1-one
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|
C20H26N6O
|
1
|
| 1 |
IC50 = 102 nM
|
|
|
|
CP0965937
|
methyl(3R,5S)-4-[3-[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3,5-dimethyl-piperazine-1-carboxylate
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|
C24H31FN8O2
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0574416
|
8-amino-2-cyclohexyl-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3,4-dihydro-2,7-naphthyridin-1-one
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|
C23H32N6O
|
1
|
| 1 |
IC50 = 133 nM
|
|
|
|
CP0579789
|
8-amino-2-cyclohexyl-5-(1-piperidin-3-ylpyrazol-4-yl)-3,4-dihydro-2,7-naphthyridin-1-one
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|
C22H30N6O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0579053
|
8-amino-2-cyclohexyl-5-(1-piperidin-4-ylpyrazol-4-yl)-3,4-dihydro-2,7-naphthyridin-1-one
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|
C22H30N6O
|
1
|
| 1 |
IC50 = 181 nM
|
|
|
|
CP0970645
|
ethyl(3R,5S)-3,5-dimethyl-4-[3-[6-[(3R)-3-methylpiperazin-1-yl]-3-pyridyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]piperazine-1-carboxylate
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|
C24H33N9O2
|
1
|
| 1 |
IC50 = 212 nM
|
|
|
|
CP0967054
|
(3R,5S)-3,5-dimethyl-4-[3-[6-[(3R)-3-methylpiperazin-1-yl]-3-pyridyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]morpholine
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|
C21H28N8O
|
1
|
| 1 |
IC50 = 245 nM
|
|
|
|
CP0579051
|
8-amino-2-cyclohexyl-5-[1-(piperidin-3-ylmethyl)pyrazol-4-yl]-3,4-dihydro-2,7-naphthyridin-1-one
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|
C23H32N6O
|
1
|
| 1 |
IC50 = 267 nM
|
|
|
|
CP0579052
|
8-amino-2-cyclohexyl-5-[1-(piperidin-4-ylmethyl)pyrazol-4-yl]-3,4-dihydro-2,7-naphthyridin-1-one
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|
C23H32N6O
|
1
|
| 1 |
IC50 = 273 nM
|
|
|
|
CP0967055
|
1-[(3R,5S)-3,5-dimethyl-4-[3-[6-[(3R)-3-methylpiperazin-1-yl]-3-pyridyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]piperazin-1-yl]-2-methoxy-ethanone
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|
C24H33N9O2
|
1
|
| 1 |
IC50 = 346 nM
|
|
|
|
CP0951945
|
(3R,5S)-N,N,3,5-tetramethyl-4-[3-[6-[(3R)-3-methylpiperazin-1-yl]-3-pyridyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]piperazine-1-carboxamide
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|
C24H34N10O
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0964932
|
5-[(2S,6R)-2,6-dimethyl-1-piperidyl]-3-[6-[(3R)-3-methylpiperazin-1-yl]-3-pyridyl]-1H-pyrazolo[4,3-d]pyrimidine
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|
C22H30N8
|
1
|
| 1 |
IC50 = 384 nM
|
|
|
|
CP0579343
|
8-amino-5-(1-piperidin-4-ylpyrazol-4-yl)-2-propan-2-yl-3,4-dihydro-2,7-naphthyridin-1-one
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|
C19H26N6O
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0567709
|
2-(2-adamantyl)-8-amino-5-(1-piperidin-4-ylpyrazol-4-yl)-3,4-dihydro-2,7-naphthyridin-1-one
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|
C26H34N6O
|
1
|
| 1 |
IC50 = 415 nM
|
|
|
|
CP0965079
|
1-[(3R,5S)-3,5-dimethyl-4-[3-[6-[(3R)-3-methylpiperazin-1-yl]-3-pyridyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]piperazin-1-yl]-2-methyl-propan-1-one
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|
C25H35N9O
|
1
|
| 1 |
IC50 = 661 nM
|
|
|
|
CP0579475
|
5-[1-(1-acetylpiperidin-4-yl)pyrazol-4-yl]-8-amino-2-cyclohexyl-3,4-dihydro-2,7-naphthyridin-1-one
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|
C24H32N6O2
|
1
|
| 1 |
IC50 = 762 nM
|
|
|
|
CP0579342
|
8-amino-2-cyclohexyl-5-(1-propan-2-ylpyrazol-4-yl)-3,4-dihydro-2,7-naphthyridin-1-one
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|
C20H27N5O
|
1
|
| 1 |
IC50 = 1083 nM
|
|
|
|
CP0567708
|
8-amino-2-cyclohexyl-5-[1-(oxetan-3-yl)pyrazol-4-yl]-3,4-dihydro-2,7-naphthyridin-1-one
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|
C20H25N5O2
|
1
|
| 1 |
IC50 = 1202 nM
|
|
|
|
CP0567707
|
8-amino-2-cyclohexyl-5-(1-cyclopentylpyrazol-4-yl)-3,4-dihydro-2,7-naphthyridin-1-one
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|
C22H29N5O
|
1
|
| 1 |
IC50 = 2474 nM
|
|
|
|
CP0970285
|
3-[6-[(3R)-3-methylpiperazin-1-yl]-3-pyridyl]-5-(1-piperidyl)-1H-pyrazolo[4,3-b]pyridine
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|
C21H27N7
|
1
|
| 1 |
IC50 > 3000 nM
|
|
|
|
CP0574417
|
8-amino-2-(4-hydroxy-4-methylcyclohexyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-3,4-dihydro-2,7-naphthyridin-1-one
Show/Hide
|
C23H32N6O2
|
1
|
| 1 |
IC50 > 3000 nM
|
|
|
