Brief Information of the Cell Line and Protein
Cell Line ID: CL000476 , A2774
 Cell Line Info 
Synonyms
A-2774
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_U376
Protein ID: PT01058 , Disintegrin and metalloproteinase domain-containing protein 17
 Protein Info 
Gene Name ADAM17
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P78536
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000476
 Cell Line Info 
 Protein ID: PT01058
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0062139
 Compound Info 
(R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-4-(hydroxyamino)-4-oxobutylcarbamate
   Show/Hide
C22H25N3O7S
  2
1
IC50 = 26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 419 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0132610
 Compound Info 
(2R)-5-(carbamoylamino)-2-[[4-[(3,5-dibromophenyl)methoxy]phenyl]sulfonylamino]-N-hydroxypentanamide
   Show/Hide
C19H22Br2N4O6S
  2
1
IC50 = 45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 651 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0073959
 Compound Info 
benzyl N-[(4R)-4-[[4-[(3,5-dibromophenyl)methoxy]phenyl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamate
   Show/Hide
C26H27Br2N3O7S
  2
1
IC50 = 274 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 7626 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0109071
 Compound Info 
benzyl N-[(3R)-3-[[4-[(3,5-dibromophenyl)methoxy]phenyl]sulfonylamino]-4-(hydroxyamino)-4-oxobutyl]carbamate
   Show/Hide
C25H25Br2N3O7S
  2
1
IC50 = 1391 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0132603
 Compound Info 
2-[[4-[(3,5-dibromophenyl)methoxy]phenyl]sulfonylamino]-N-hydroxyacetamide
   Show/Hide
C15H14Br2N2O5S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS