| Compound ID |
Compound Name |
Compound Formula |
|
CP0266599
|
1-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methylmorpholin-4-yl]methyl]piperazin-1-yl]ethanone
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C29H40FN5O2
|
2
|
| 1 |
EC50 = 5.1 nM
|
|
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| 2 |
IC50 = 5.1 nM
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|
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CP0231623
|
US9018214, 234
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C28H38FN5O2
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
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CP0544254
|
US9018214, 219
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C28H37F2N5O2
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
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CP0144533
|
US9018214, 203
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C28H36F3N5O
|
1
|
| 1 |
EC50 = 17 nM
|
|
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CP0566033
|
1-[[(2R,5R)-1-[2-[6-[difluoro(phenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]pyrrolidin-2-one
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|
C28H35F2N5O2
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
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CP0574311
|
US9018214, 202
Show/Hide
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C28H36F3N5O
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
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CP0513569
|
1-[[(2R,5R)-1-[2-[6-(1,1-difluorobutyl)-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]pyrrolidin-2-one
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|
C25H37F2N5O2
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
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CP0077521
|
(2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide
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|
C26H33FN4O3S
|
2
|
| 1 |
EC50 = 35 nM
|
|
|
| 2 |
IC50 = 35 nM
|
|
|
|
CP0547914
|
US9018214, 240
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C29H40FN5O2
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
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CP0547912
|
1-[[(2R,5R)-1-[2-[6-[(2,4-difluorophenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]pyrrolidin-2-one
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|
C28H35F2N5O2
|
1
|
| 1 |
EC50 = 67 nM
|
|
|
|
CP0122118
|
US9018214, 199
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C28H35F2N5O2
|
1
|
| 1 |
EC50 = 69 nM
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|
|
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CP0547913
|
1-[[(2R,5R)-1-[2-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]pyrrolidin-2-one
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|
C28H36FN5O2
|
1
|
| 1 |
EC50 = 73 nM
|
|
|
|
CP0327287
|
US9018214, 180
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|
C28H37N5O2
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0223574
|
US9018214, 188
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|
C23H33F2N5O2
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
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CP0106277
|
US9018214, 190
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|
C24H35F2N5O2
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
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CP0199527
|
US9018214, 220
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|
C28H37F2N5O
|
1
|
| 1 |
EC50 = 180 nM
|
|
|
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CP0386973
|
1-[2-[(2R,5R)-2-[[(3R,5R)-3,5-dimethylmorpholin-4-yl]methyl]-5-methylpiperazin-1-yl]acetyl]-6-[(4-fluorophenyl)methyl]-3,3,4-trimethyl-2H-pyrrolo[3,2-b]pyridin-5-one
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|
C31H44FN5O3
|
1
|
| 1 |
IC50 = 0.83 nM
|
|
|
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CP0475597
|
2-[(2R,5R)-2-[[(3R,5R)-3,5-dimethylmorpholin-4-yl]methyl]-5-methylpiperazin-1-yl]-1-[6-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]ethanone
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|
C31H44FN5O3
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0356374
|
1-[6-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methylmorpholin-4-yl]methyl]piperazin-1-yl]ethanone
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|
C30H42FN5O3
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
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CP0486045
|
2-[(2R,5R)-2-[[(3R,5R)-3,5-dimethylmorpholin-4-yl]methyl]-5-methylpiperazin-1-yl]-1-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]ethanone
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|
C30H42FN5O2
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
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CP0521075
|
2-[[(2R,5R)-1-[2-[3-[(2,4-difluorophenyl)methyl]-7,7-dimethyl-6H-pyrrolo[3,2-c]pyridazin-5-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]-5-fluoro-3H-isoindol-1-one
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|
C31H33F3N6O2
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
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CP0427159
|
2-[[(2R,5R)-1-[2-[3-[(2,4-difluorophenyl)methyl]-7,7-dimethyl-6H-pyrrolo[3,2-c]pyridazin-5-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]-4-fluoro-3H-isoindol-1-one
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|
C31H33F3N6O2
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
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CP0386974
|
1-[2-[(2R,5R)-2-[[(3R,5R)-3,5-dimethylmorpholin-4-yl]methyl]-5-methylpiperazin-1-yl]acetyl]-6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2,4-dihydropyrrolo[3,2-b]pyridin-5-one
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|
C30H42FN5O3
|
1
|
| 1 |
IC50 = 5.4 nM
|
|
|
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CP0475599
|
2-[[(2R,5R)-1-[2-[3-[(2,4-difluorophenyl)methyl]-7,7-dimethyl-6H-pyrrolo[3,2-c]pyridazin-5-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]-3-oxo-1H-isoindole-5-carbonitrile
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|
C32H33F2N7O2
|
1
|
| 1 |
IC50 = 5.8 nM
|
|
|
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CP0386977
|
2-[(2R,5R)-2-[[(3R,5R)-3,5-dimethylmorpholin-4-yl]methyl]-5-methylpiperazin-1-yl]-1-[6-[(S)-(4-fluorophenyl)-hydroxymethyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]ethanone
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|
C30H42FN5O3
|
1
|
| 1 |
IC50 = 7.4 nM
|
|
|
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CP0475600
|
2-[[(2R,5R)-1-[2-[3-[(2,4-difluorophenyl)methyl]-7,7-dimethyl-6H-pyrrolo[3,2-c]pyridazin-5-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]-6-fluoro-3H-isoindol-1-one
Show/Hide
|
C31H33F3N6O2
|
1
|
| 1 |
IC50 = 7.5 nM
|
|
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CP0486044
|
2-[[(2R,5R)-1-[2-[3-[(2,4-difluorophenyl)methyl]-7,7-dimethyl-6H-pyrrolo[3,2-c]pyridazin-5-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]-3H-isoindol-1-one
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|
C31H34F2N6O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
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CP0386980
|
(6R)-4-[[(2R,5R)-1-[2-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]-6-methylmorpholin-3-one
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|
C29H38FN5O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
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CP0440745
|
2-[(2R,5R)-2-[[(3R,5S)-3,5-dimethylmorpholin-4-yl]methyl]-5-methylpiperazin-1-yl]-1-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]ethanone
Show/Hide
|
C30H42FN5O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
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CP0475596
|
1-[2-[(2R,5R)-2-[[(3R,5R)-3,5-dimethylmorpholin-4-yl]methyl]-5-methylpiperazin-1-yl]acetyl]-6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2H-pyrrolo[2,3-c]pyridin-5-one
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|
C30H42FN5O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
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CP0486043
|
2-[[(2R,5R)-1-[2-[3-[(2,4-difluorophenyl)methyl]-7,7-dimethyl-6H-pyrrolo[3,2-c]pyridazin-5-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]-1-oxo-3H-isoindole-5-carbonitrile
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|
C32H33F2N7O2
|
1
|
| 1 |
IC50 = 16 nM
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CP0408548
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2-[(2R,5R)-2-[[(3R,5R)-3,5-dimethylmorpholin-4-yl]methyl]-5-methylpiperazin-1-yl]-1-[6-[(4-fluoro-2-hydroxyphenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]ethanone
Show/Hide
|
C30H42FN5O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
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CP0482583
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1-[[(2R,5R)-1-[2-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]-3,4-dimethyl-2H-pyrrol-5-one
Show/Hide
|
C30H38FN5O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
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CP0408551
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2-[(2R,5R)-2-[[(2R,5R)-2,5-dimethylmorpholin-4-yl]methyl]-5-methylpiperazin-1-yl]-1-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]ethanone
Show/Hide
|
C30H42FN5O2
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1
|
| 1 |
IC50 = 20 nM
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CP0427160
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2-[[(2R,5R)-1-[2-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]-3H-isoindol-1-one
Show/Hide
|
C32H36FN5O2
|
1
|
| 1 |
IC50 = 30 nM
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CP0386979
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2-[[(2R,5R)-1-[2-[3-[(4-fluorophenyl)methyl]-7,7-dimethyl-6H-pyrrolo[3,2-c]pyridazin-5-yl]-2-oxoethyl]-5-methylpiperazin-2-yl]methyl]-3H-isoindol-1-one
Show/Hide
|
C31H35FN6O2
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1
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| 1 |
IC50 = 47 nM
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CP0440720
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2-[(2R,5R)-2-[[(3R,5R)-3,5-dimethylmorpholin-4-yl]methyl]-5-methylpiperazin-1-yl]-1-[6-[(R)-(4-fluorophenyl)-hydroxymethyl]-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]ethanone
Show/Hide
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C30H42FN5O3
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1
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| 1 |
IC50 = 47 nM
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