Brief Information of the Cell Line and Protein
Cell Line ID: CL000007 , HT-29
Synonyms
HT 29
HT29
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0320
Protein ID: PT00954 , Receptor-interacting serine/threonine-protein kinase 1
Gene Name RIPK1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q13546
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000007  Protein ID: PT00954
 
Compound ID Compound Name Compound Formula
CP0535733
N,2,2-trimethyl-N-[(2,3,5-trifluorophenyl)methyl]butanamide
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C14H18F3NO
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0246542
N-benzyl-N-hydroxy-2,2-dimethylbutanamide
   Show/Hide
C13H19NO2
 1
1
EC50 = 28 nM
   TI
   LI
   LO
   TS
CP0572491
N-[(2,5-difluorophenyl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C14H19F2NO
 1
1
EC50 = 36 nM
   TI
   LI
   LO
   TS
CP0564168
N-hydroxy-2,2-dimethyl-N-[(3,4,5-trifluorophenyl)methyl]butanamide
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C13H16F3NO2
 1
1
EC50 = 49 nM
   TI
   LI
   LO
   TS
CP0451780
N-[(3,4-difluorophenyl)methyl]-N-hydroxy-2,2-dimethylbutanamide
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C13H17F2NO2
 1
1
EC50 = 56 nM
   TI
   LI
   LO
   TS
CP0564170
N-[(2,3-difluorophenyl)methyl]-N,2,2-trimethylbutanamide
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C14H19F2NO
 1
1
EC50 = 58 nM
   TI
   LI
   LO
   TS
CP0454881
N-[(4-fluorophenyl)methyl]-N-hydroxy-2,2-dimethylbutanamide
   Show/Hide
C13H18FNO2
 1
1
EC50 = 64 nM
   TI
   LI
   LO
   TS
CP0481010
N-[(3-fluorophenyl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C14H20FNO
 1
1
EC50 = 72 nM
   TI
   LI
   LO
   TS
CP0550716
N-hydroxy-2,2-dimethyl-N-[(2,3,5-trifluorophenyl)methyl]butanamide
   Show/Hide
C13H16F3NO2
 1
1
EC50 = 74 nM
   TI
   LI
   LO
   TS
CP0564169
N,2,2-trimethyl-N-[(2,3,5-trifluorophenyl)methyl]propanamide
   Show/Hide
C13H16F3NO
 1
1
EC50 = 98 nM
   TI
   LI
   LO
   TS
CP0513681
N-[(2-fluorophenyl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C14H20FNO
 1
1
EC50 = 125 nM
   TI
   LI
   LO
   TS
CP0548623
N-[(2,4-difluorophenyl)methyl]-N-hydroxy-2,2-dimethylbutanamide
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C13H17F2NO2
 1
1
EC50 = 198 nM
   TI
   LI
   LO
   TS
CP0542263
N,2,2-trimethyl-N-(thiophen-2-ylmethyl)butanamide
   Show/Hide
C12H19NOS
 1
1
EC50 = 221 nM
   TI
   LI
   LO
   TS
CP0547407
N-hydroxy-2,2-dimethyl-N-[(2,3,4-trifluorophenyl)methyl]butanamide
   Show/Hide
C13H16F3NO2
 1
1
EC50 = 262 nM
   TI
   LI
   LO
   TS
CP0563183
N,2,2-trimethyl-N-[(5-methylthiophen-2-yl)methyl]butanamide
   Show/Hide
C13H21NOS
 1
1
EC50 = 378 nM
   TI
   LI
   LO
   TS
CP0479705
N-benzyl-N,2,2-trimethylbutanamide
   Show/Hide
C14H21NO
 1
1
EC50 = 457 nM
   TI
   LI
   LO
   TS
CP0550666
N,1-dimethyl-N-[(2,3,5-trifluorophenyl)methyl]cyclohexane-1-carboxamide
   Show/Hide
C16H20F3NO
 1
1
EC50 = 490 nM
   TI
   LI
   LO
   TS
CP0458651
N-[(2,4-difluorophenyl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C14H19F2NO
 1
1
EC50 = 627 nM
   TI
   LI
   LO
   TS
CP0458652
N-[(3-chlorophenyl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C14H20ClNO
 1
1
EC50 = 628 nM
   TI
   LI
   LO
   TS
CP0542262
N-(furan-2-ylmethyl)-N,2,2-trimethylbutanamide
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C12H19NO2
 1
1
EC50 = 628 nM
   TI
   LI
   LO
   TS
CP0547409
N-methyl-1-(trifluoromethyl)-N-[(2,3,5-trifluorophenyl)methyl]cyclobutane-1-carboxamide
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C14H13F6NO
 1
1
EC50 = 656 nM
   TI
   LI
   LO
   TS
CP0563185
N-[(4-fluorophenyl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C14H20FNO
 1
1
EC50 = 815 nM
   TI
   LI
   LO
   TS
CP0547410
N-[(2-fluorophenyl)methyl]-2,2-dimethylbutanamide
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C13H18FNO
 1
1
EC50 = 898 nM
   TI
   LI
   LO
   TS
CP0548620
N-(2-hydroxy-1-phenylethyl)-2,2-dimethylbutanamide
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C14H21NO2
 1
1
EC50 = 1077 nM
   TI
   LI
   LO
   TS
CP0413313
N-[(3-bromophenyl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C14H20BrNO
 1
1
EC50 = 1233 nM
   TI
   LI
   LO
   TS
CP0479700
N-methyl-1-(trifluoromethyl)-N-[(2,3,5-trifluorophenyl)methyl]cyclopentane-1-carboxamide
   Show/Hide
C15H15F6NO
 1
1
EC50 = 1234 nM
   TI
   LI
   LO
   TS
CP0481009
N,2,2-trimethyl-N-[(2,4,6-trifluorophenyl)methyl]butanamide
   Show/Hide
C14H18F3NO
 1
1
EC50 = 1254 nM
   TI
   LI
   LO
   TS
CP0578681
N-[(4,5-dimethylthiophen-2-yl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C14H23NOS
 1
1
EC50 = 1308 nM
   TI
   LI
   LO
   TS
CP0563181
N,2,6-trimethyl-N-[(2,3,5-trifluorophenyl)methyl]piperidine-1-carboxamide
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C16H21F3N2O
 1
1
EC50 = 1526 nM
   TI
   LI
   LO
   TS
CP0481008
N,2,2-trimethyl-N-(pyridin-3-ylmethyl)butanamide
   Show/Hide
C13H20N2O
 1
1
EC50 = 1735 nM
   TI
   LI
   LO
   TS
CP0565861
N,2,2-trimethyl-N-[(3-methylthiophen-2-yl)methyl]butanamide
   Show/Hide
C13H21NOS
 1
1
EC50 = 2527 nM
   TI
   LI
   LO
   TS
CP0533988
N-benzyl-2,2-dimethylbutanamide
   Show/Hide
C13H19NO
 1
1
EC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0572488
N-methyl-N-[(2,3,5-trifluorophenyl)methyl]cyclobutanecarboxamide
   Show/Hide
C13H14F3NO
 1
1
EC50 = 8237 nM
   TI
   LI
   LO
   TS
CP0483551
N-[(2-bromophenyl)methyl]-2,2-dimethylbutanamide
   Show/Hide
C13H18BrNO
 1
1
EC50 = 8562 nM
   TI
   LI
   LO
   TS
CP0413312
N,2,2-trimethyl-N-(2-phenylpropan-2-yl)butanamide
   Show/Hide
C16H25NO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0447661
N-[(3-bromophenyl)methyl]-2,2-dimethylbutanamide
   Show/Hide
C13H18BrNO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0451758
N-[(2-chlorophenyl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C14H20ClNO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0454882
2-methoxy-N,2-dimethyl-N-[(2,3,5-trifluorophenyl)methyl]propanamide
   Show/Hide
C13H16F3NO2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0479703
N-[(3-fluoropyridin-4-yl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C13H19FN2O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0483549
N,2,2-trimethyl-N-[(1-methylpyrazol-3-yl)methyl]butanamide
   Show/Hide
C12H21N3O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0541678
N,1-dimethyl-N-[(2,3,5-trifluorophenyl)methyl]cyclopropane-1-carboxamide
   Show/Hide
C13H14F3NO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0542264
N-ethyl-N-[(2-fluorophenyl)methyl]-2,2-dimethylbutanamide
   Show/Hide
C15H22FNO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0548621
N,2,2-trimethyl-N-(1-phenylethyl)butanamide
   Show/Hide
C15H23NO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0550717
N-(2-hydroxy-1-phenylethyl)-N,2,2-trimethylbutanamide
   Show/Hide
C15H23NO2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0563177
2,2-dimethyl-N-(2-phenylpropan-2-yl)butanamide
   Show/Hide
C15H23NO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0563179
2,2-dimethyl-N-(1-phenylethyl)butanamide
   Show/Hide
C14H21NO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0565862
N,2,2-trimethyl-N-(pyridin-4-ylmethyl)butanamide
   Show/Hide
C13H20N2O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0572490
N,2,2-trimethyl-N-[(2-methyl-1,3-thiazol-5-yl)methyl]butanamide
   Show/Hide
C12H20N2OS
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0483550
N-[(3-hydroxyphenyl)methyl]-N,2,2-trimethylbutanamide
   Show/Hide
C14H21NO2
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0489645
1-methyl-3,3-di(propan-2-yl)-1-[(2,3,5-trifluorophenyl)methyl]urea
   Show/Hide
C15H21F3N2O
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0542245
1,3-dimethyl-1-propan-2-yl-3-[(2,3,5-trifluorophenyl)methyl]urea
   Show/Hide
C13H17F3N2O
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0547408
N,2-dimethyl-N-[(2,3,5-trifluorophenyl)methyl]piperidine-1-carboxamide
   Show/Hide
C15H19F3N2O
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0548622
3-hydroxy-N,2,2-trimethyl-N-[(2,3,5-trifluorophenyl)methyl]propanamide
   Show/Hide
C13H16F3NO2
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0563175
2,2-dimethyl-N-(1-phenylcyclopropyl)butanamide
   Show/Hide
C15H21NO
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS