Brief Information of the Cell Line and Protein
Cell Line ID: CL000752 , PBMC iPSC #1
Category Induced pluripotent stem cell
Organism
Homo sapiens (Human)
Protein ID: PT00892 , Tyrosine-protein kinase JAK3
Gene Name JAK3
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P52333
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000752  Protein ID: PT00892
 
Compound ID Compound Name Compound Formula
CP0008733
[(1S)-1-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydroinden-1-yl]cyanamide
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C17H15N5
 1
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
CP0014853
N-[3-[5-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]prop-2-enamide
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C18H18N4O2
 1
1
IC50 = 63 nM
   TI
   LI
   LO
   TS
CP0001795
2,2-difluoro-6-[5-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3H-1,4-benzoxazine-4-carbonitrile
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C18H15F2N5O2
 1
1
IC50 = 162 nM
   TI
   LI
   LO
   TS
CP0001796
N-[(1R,3S)-3-(cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-3-fluorobenzenesulfonamide
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C22H17FN6O2S
 1
1
IC50 = 331 nM
   TI
   LI
   LO
   TS
CP0001797
[(1S)-6-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide
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C22H17N5
 1
1
IC50 = 458 nM
   TI
   LI
   LO
   TS
CP0014854
3-cyano-N-[(1R,3S)-3-(cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]benzenesulfonamide
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C23H17N7O2S
 1
1
IC50 = 468 nM
   TI
   LI
   LO
   TS
CP0014520
[(1S)-6-[5-[3-(hydroxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1H-inden-1-yl]cyanamide
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C23H19N5O
 1
1
IC50 = 498 nM
   TI
   LI
   LO
   TS
CP0004518
[(1S)-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide
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C16H13N5
 1
1
IC50 = 598 nM
   TI
   LI
   LO
   TS
CP0001779
N-[(1R,3S)-3-(cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-4-methoxybenzenesulfonamide
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C23H20N6O3S
 1
1
IC50 = 947 nM
   TI
   LI
   LO
   TS
CP0004519
[(1S,3R)-3-hydroxy-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide
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C16H13N5O
 1
1
IC50 = 1728 nM
   TI
   LI
   LO
   TS
CP0013445
N-[(1R,3S)-3-(cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]methanesulfonamide
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C17H16N6O2S
 1
1
IC50 = 2240 nM
   TI
   LI
   LO
   TS