Brief Information of the Cell Line and Protein
Cell Line ID: CL000157 , NCI-H1975
Synonyms
H1975
H-1975
NCIH1975
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1511
Protein ID: PT00845 , RAC-alpha serine/threonine-protein kinase
Gene Name AKT1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P31749
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000157  Protein ID: PT00845
 
Compound ID Compound Name Compound Formula
CP0573911
N-[3-[2-[4-[4-[8-[[2-(1-adamantyl)acetyl]amino]octyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
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C48H62N8O4
 1
1
EC50 = 168 nM
   TI
   LI
   LO
   TS
CP0551614
N-[3-[2-[4-[4-[2-[2-[2-[[2-(1-adamantyl)acetyl]amino]ethoxy]ethoxy]ethyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
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C46H58N8O6
 1
1
EC50 = 300 nM
   TI
   LI
   LO
   TS
CP0203178
N-[3-[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
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C29H31N7O3
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0544748
N-[3-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]-2,2-dimethylpropanamide
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C54H76N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0546212
N-[3-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
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C52H70N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0546213
N-[3-[2-[4-[4-[6-[[2-(1-adamantyl)acetyl]amino]hexyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
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C46H58N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0546214
N-[3-[2-[4-[4-[14-[[2-(1-adamantyl)acetyl]amino]tetradecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
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C54H74N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0546215
N-[3-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]cyclopropanecarboxamide
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C53H72N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0551613
N-[3-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]-2-methylpropanamide
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C53H74N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0551615
N-[3-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecanoyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
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C52H68N8O5
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0551616
N-[12-[4-[4-[[8-(3-acetamidophenyl)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]dodecyl]-2-(1-adamantyl)acetamide
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C51H70N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0562844
2-(1-adamantyl)-N-[12-[4-[4-[[8-(3-aminophenyl)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]dodecyl]acetamide
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C49H68N8O3
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0572863
N-[3-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]propanamide
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C52H72N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0575210
N-[4-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
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C52H70N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0576645
N-[3-[2-[4-[4-[10-[[2-(1-adamantyl)acetyl]amino]decyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
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C50H66N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0576646
N-[4-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]cyclopropanecarboxamide
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C53H72N8O4
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS