| Compound ID |
Compound Name |
Compound Formula |
|
CP0576003
|
(5R)-4-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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|
C25H31ClN6O2
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0568350
|
(4S)-5-[(1R,5S)-8-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one
Show/Hide
|
C25H31ClN6O3
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0569793
|
(4S)-5-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one
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|
C24H29ClN6O3
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0577114
|
(5R)-4-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-(cyclopropylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C25H29ClN6O2
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0571317
|
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-methyl-6,8-dihydropteridin-7-one;hydrochloride
Show/Hide
|
C23H31Cl2N7O2
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0088096
|
(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
Show/Hide
|
C24H32ClN5O2
|
2
|
| 1 |
IC50 = 1.3 nM
|
|
|
| 2 |
IC50 = 3.8 nM
|
|
|
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CP0571316
|
(5R)-4-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-[(4-methoxycyclohexyl)amino]propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C29H37ClN6O3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0578923
|
(4S)-5-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one
Show/Hide
|
C23H29ClN6O3
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0543716
|
(4S)-5-[(1R,5S)-3-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one
Show/Hide
|
C25H31ClN6O3
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0545494
|
(5R)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C24H31ClN6O2
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0965432
|
(R)-4-(4-((S)-2-(4-chlorophenyl)-3-(isopropylamino)propanoyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
Show/Hide
|
C24H31ClN6O2
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0480237
|
N-[(3S,4S)-4-(3,5-difluorophenyl)piperidin-3-yl]-3-fluoro-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H22ClF3N4O
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0577369
|
4-[8-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-5-methyl-6,8-dihydropteridin-7-one;formic acid
Show/Hide
|
C26H34ClN7O4
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0552081
|
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C24H31ClN6O2
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0533998
|
N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-3-fluoro-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H22ClF3N4O
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0576733
|
(5R)-4-[8-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C26H33ClN6O2
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0577366
|
(5R)-4-[3-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C26H33ClN6O2
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0130706
|
N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-2-fluoro-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H22ClF3N4O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0573075
|
(5R)-4-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-(3-oxabicyclo[3.1.0]hexan-6-ylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C27H31ClN6O3
|
1
|
| 1 |
IC50 = 4.1 nM
|
|
|
|
CP0531401
|
N-[(3S,4S)-4-(3,5-difluorophenyl)piperidin-3-yl]-2-fluoro-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H22ClF3N4O
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0569440
|
5-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one
Show/Hide
|
C23H29ClN6O3
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0577367
|
(5R)-4-[(1S,6R)-5-[(2S)-3-amino-2-(4-chlorophenyl)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C22H25ClN6O2
|
1
|
| 1 |
IC50 = 6.8 nM
|
|
|
|
CP0423418
|
N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-2,5-difluoro-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H21ClF4N4O
|
1
|
| 1 |
IC50 = 9.2 nM
|
|
|
|
CP0579115
|
(5R)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-(trifluoromethyl)-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C24H28ClF3N6O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0550487
|
(2R,4S)-11-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6,8,10-triazatricyclo[5.4.0.02,4]undeca-1(7),8,10-trien-5-one
Show/Hide
|
C24H29ClN6O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0480236
|
2-chloro-N-[(3S,4S)-4-(3,5-difluorophenyl)piperidin-3-yl]-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H22Cl2F2N4O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0451203
|
N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-4-(2-methylpyrazol-3-yl)benzamide
Show/Hide
|
C22H22F2N4O
|
1
|
| 1 |
IC50 = 21.6 nM
|
|
|
|
CP0578377
|
4-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydropteridin-7-one
Show/Hide
|
C24H30ClN7O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0480243
|
2-chloro-N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H22Cl2F2N4O
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0547235
|
(6S)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C24H31ClN6O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0553130
|
N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-2,6-difluoro-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H21ClF4N4O
|
1
|
| 1 |
IC50 = 26.3 nM
|
|
|
|
CP0578352
|
(5R)-4-[(2R)-4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2-methylpiperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C25H33ClN6O2
|
1
|
| 1 |
IC50 = 26.4 nM
|
|
|
|
CP0577368
|
(5R)-4-[(3R)-4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3-methylpiperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C25H33ClN6O2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
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CP0543699
|
4-[(1R,5S)-3-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-5-methyl-6,8-dihydropteridin-7-one
Show/Hide
|
C25H32ClN7O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
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CP0418880
|
2,5-difluoro-N-[(3S,4S)-4-(4-fluorophenyl)piperidin-3-yl]-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H22ClF3N4O
|
1
|
| 1 |
IC50 = 35.3 nM
|
|
|
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CP0562652
|
2-chloro-N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-6-fluoro-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H21Cl2F3N4O
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
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CP0480234
|
4-(4-chloro-2-methylpyrazol-3-yl)-N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-2,5-difluorobenzamide;hydrochloride
Show/Hide
|
C22H20Cl2F4N4O
|
1
|
| 1 |
IC50 = 48.9 nM
|
|
|
|
CP0569441
|
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C23H29ClN6O2
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0547250
|
(5R)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-4,7-diazaspiro[2.5]octan-7-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C26H33ClN6O2
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0577102
|
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one;hydrochloride
Show/Hide
|
C24H32Cl2N6O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0550489
|
(5R)-4-[(1R,6S)-5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C25H31ClN6O2
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
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CP0480235
|
4-(4-bromo-2-methylpyrazol-3-yl)-N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-2,5-difluorobenzamide;hydrochloride
Show/Hide
|
C22H20BrClF4N4O
|
1
|
| 1 |
IC50 = 66.2 nM
|
|
|
|
CP0550443
|
(2S,4R)-11-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6,8,10-triazatricyclo[5.4.0.02,4]undeca-1(7),8,10-trien-5-one
Show/Hide
|
C24H29ClN6O2
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0570248
|
(6R)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C24H31ClN6O2
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
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CP0907361
|
N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1H-pyrazol-5-yl)benzamide Hydrochloride
Show/Hide
|
C21H20ClF3N4O
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
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CP0569570
|
4-(4-bromo-2-methylpyrazol-3-yl)-N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-2,6-difluorobenzamide;hydrochloride
Show/Hide
|
C22H20BrClF4N4O
|
1
|
| 1 |
IC50 = 95.7 nM
|
|
|
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CP0547755
|
4-(4-chloro-2-methylpyrazol-3-yl)-N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-2,6-difluorobenzamide;hydrochloride
Show/Hide
|
C22H20Cl2F4N4O
|
1
|
| 1 |
IC50 = 97.1 nM
|
|
|
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CP0573226
|
2,6-difluoro-N-[(3S,4S)-4-(4-fluorophenyl)piperidin-3-yl]-4-(2-methylpyrazol-3-yl)benzamide;hydrochloride
Show/Hide
|
C22H22ClF3N4O
|
1
|
| 1 |
IC50 = 107.2 nM
|
|
|
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CP0444667
|
4-(4-bromo-2-methylpyrazol-3-yl)-2-chloro-N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-6-fluorobenzamide;hydrochloride
Show/Hide
|
C22H20BrCl2F3N4O
|
1
|
| 1 |
IC50 = 136.8 nM
|
|
|
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CP0418906
|
2-chloro-4-(4-chloro-2-methylpyrazol-3-yl)-N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-6-fluorobenzamide;hydrochloride
Show/Hide
|
C22H20Cl3F3N4O
|
1
|
| 1 |
IC50 = 142.5 nM
|
|
|
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CP0569439
|
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-methyl-7,8-dihydropteridin-6-one
Show/Hide
|
C23H30ClN7O2
|
1
|
| 1 |
IC50 = 146 nM
|
|
|
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CP0533997
|
N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-4-(2-ethylpyrazol-3-yl)-2-fluorobenzamide;hydrochloride
Show/Hide
|
C23H24ClF3N4O
|
1
|
| 1 |
IC50 = 176 nM
|
|
|
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CP0552089
|
(4R)-5-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one;formic acid
Show/Hide
|
C24H31ClN6O5
|
1
|
| 1 |
IC50 = 201 nM
|
|
|
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CP0568923
|
(5R)-4-[(3S)-4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3-methylpiperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one;formic acid
Show/Hide
|
C26H35ClN6O4
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
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CP0543850
|
(5R)-4-[(3aR,6aS)-5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C26H33ClN6O2
|
1
|
| 1 |
IC50 = 285 nM
|
|
|
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CP0552082
|
(5R)-4-[5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C25H31ClN6O2
|
1
|
| 1 |
IC50 = 414 nM
|
|
|
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CP0571318
|
(5S)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-(trifluoromethyl)-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C24H28ClF3N6O2
|
1
|
| 1 |
IC50 = 776 nM
|
|
|
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CP0545500
|
(5R)-4-[1-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,6-dihydro-2H-pyridin-4-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
|
C25H30ClN5O2
|
1
|
| 1 |
IC50 = 951 nM
|
|
|
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CP0012721
|
[3-[4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl]azetidin-1-yl]-[4-[[(2S)-2,3-dihydroxypropoxy]methyl]pyridin-2-yl]methanone
Show/Hide
|
C30H34N2O6
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
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CP0545487
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(5R)-4-[2-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,6-diazaspiro[3.3]heptan-6-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H31ClN6O2
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1
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| 1 |
IC50 > 1000 nM
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CP0550463
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(5R)-4-[1-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperidin-4-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H32ClN5O2
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1
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| 1 |
IC50 > 1000 nM
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CP0576731
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(2S)-2-(4-chlorophenyl)-1-[4-[6-(hydroxymethyl)-5-methylpyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
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C22H30ClN5O2
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1
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| 1 |
IC50 > 1000 nM
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CP0576732
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4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-1H-pyridin-2-one
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C21H27ClN4O2
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1
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| 1 |
IC50 > 1000 nM
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CP0579114
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(5S)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C24H31ClN6O2
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1
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| 1 |
IC50 > 1000 nM
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