General Information of the Compound
Compound ID
CP0970401
Compound Name
3-[[5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl]methyl]-N-(3-hydroxy-3-methyl-cyclobutyl)cyclobutanecarboxamide
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Structure
Formula
C25H25F3N2O2
Molecular Weight
442.481
Canonical SMILES
CC1(O)CC(NC(=O)C2CC(Cc3c(-c4ccc(F)cc4)[nH]c4c(F)cc(F)cc34)C2)C1
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InChI
InChI=1S/C25H25F3N2O2/c1-25(32)11-18(12-25)29-24(31)15-6-13(7-15)8-19-20-9-17(27)10-21(28)23(20)30-22(19)14-2-4-16(26)5-3-14/h2-5,9-10,13,15,18,30,32H,6-8,11-12H2,1H3,(H,29,31)
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InChIKey
LZECOHJYFDWYCE-UHFFFAOYSA-N
Physicochemical Property
logP
4.8505
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
65.12
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
2
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156815976
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT07126, Apolipoprotein L1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000058 T-REx-293 Homo sapiens (Human)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS