General Information of the Protein
Protein ID
PT07126
Protein Name
Apolipoprotein L1
Secondarily
Protein Name
Apolipoprotein L
Apolipoprotein L-I
Gene Name
APOL1
Secondarily
Gene Name
APOL
Sequence
MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
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Uniprot ID
Primary ID:
O14791

Secondarily ID:
A5PLQ4
B4DU12
E9PF24
O60804
Q5R3P7
Q5R3P8
Q96AB8
Q96PM4
Q9BQ03
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Ensembl ID
ENSG00000100342
HGNC ID
HGNC:618
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0902820
3-[5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(3S,4S)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide
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C21H18F3N3O3
 1
1
IC50 < 250 nM
   TI
   LI
   LO
   TS
CP0902821
N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]-3-[2-(4-methoxyphenyl)-1H-indol-3-yl]propanamide
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C22H23N3O4
 1
1
IC50 < 250 nM
   TI
   LI
   LO
   TS
CP0947392
3-[7-cyano-5-fluoro-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide
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C22H18F2N4O3
 1
1
IC50 < 250 nM
   TI
   LI
   LO
   TS
CP0950477
3-[2-(4-cyanophenyl)-5,7-difluoro-1H-indol-3-yl]-N-[(3S)-2-oxopyrrolidin-3-yl]propanamide
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C22H18F2N4O2
 1
1
IC50 < 250 nM
   TI
   LI
   LO
   TS
CP0957907
3-(7-fluoro-2-phenyl-1H-indol-3-yl)-N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide
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C21H20FN3O3
 1
1
IC50 < 250 nM
   TI
   LI
   LO
   TS
CP0957908
3-(5,6-difluoro-2-phenyl-1H-indol-3-yl)-N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide
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C21H19F2N3O3
 1
1
IC50 < 250 nM
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Apolipoprotein L1 messenger RNA (APOL1 mRNA) )
Target Type Clinical trial Target