General Information of the Compound
Compound ID
CP0970148
Compound Name
1-((1-acryloyl-3-fluoroazetidin-3-yl)methyl)-7-chloro-6-(5-chlorobenzo[d][1,3]dioxol-4-yl)-4-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-b]pyrazine-2,3(1H,4H)-dione
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Formula
C30H26Cl2FN5O5
Molecular Weight
626.472
Canonical SMILES
C=CC(=O)N1CC(F)(Cn2c(=O)c(=O)n(-c3c(C)ccnc3C(C)C)c3nc(-c4c(Cl)ccc5c4OCO5)c(Cl)cc32)C1
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InChI
InChI=1S/C30H26Cl2FN5O5/c1-5-21(39)36-11-30(33,12-36)13-37-19-10-18(32)24(22-17(31)6-7-20-26(22)43-14-42-20)35-27(19)38(29(41)28(37)40)25-16(4)8-9-34-23(25)15(2)3/h5-10,15H,1,11-14H2,2-4H3
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InChIKey
XGOCTGCGXRJDQF-UHFFFAOYSA-N
Physicochemical Property
logP
4.81322
Rotatable Bonds
6
Heavy Atom Count
43
Polar Areas
108.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03462, GTPase KRas
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000207 MIA PaCa-2 Homo sapiens (Human)  1
1
IC50 <= 100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 <= 100 nM