General Information of the Compound
Compound ID
CP0968718
Compound Name
(S)-3-(7-fluoro-2-phenyl-1H-indol-3-yl)-N-(2-oxopyrrolidin-3-yl)propanamide
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Structure
Formula
C21H20FN3O2
Molecular Weight
365.408
Canonical SMILES
O=C(CCc1c(-c2ccccc2)[nH]c2c(F)cccc12)N[C@H]1CCNC1=O
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InChI
InChI=1S/C21H20FN3O2/c22-16-8-4-7-14-15(9-10-18(26)24-17-11-12-23-21(17)27)19(25-20(14)16)13-5-2-1-3-6-13/h1-8,17,25H,9-12H2,(H,23,27)(H,24,26)/t17-/m0/s1
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InChIKey
PFHXOZYAIKUHOI-KRWDZBQOSA-N
Physicochemical Property
logP
2.9113
Rotatable Bonds
5
Heavy Atom Count
27
Polar Areas
73.99
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
2
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 153620155
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT07126, Apolipoprotein L1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000058 T-REx-293 Homo sapiens (Human)  1
1
IC50 = 250 nM
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