General Information of the Compound
Compound ID
CP0963886
Compound Name
2-[[4-[4-(5-fluoro-2-methoxy-phenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl]amino]acetic acid
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Structure
Formula
C22H22FN3O3
Molecular Weight
395.434
Canonical SMILES
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(NCC(=O)O)CC3)cc12
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InChI
InChI=1S/C22H22FN3O3/c1-29-20-7-4-14(23)10-17(20)16-8-9-24-22-18(16)11-19(26-22)13-2-5-15(6-3-13)25-12-21(27)28/h2,4,7-11,15,25H,3,5-6,12H2,1H3,(H,24,26)(H,27,28)
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InChIKey
HUXIUBXCPRIWRC-UHFFFAOYSA-N
Physicochemical Property
logP
3.9877
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
87.24
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90419536
ChEMBL ID
CHEMBL4872494
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01235, Cyclin-dependent kinase 9
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431 Homo sapiens (Human)  1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 63 nM