General Information of the Compound
Compound ID
CP0953206
Compound Name
(2S)-2-[[3-[5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl]cyclobutyl]methylamino]-N-(2,2,2-trifluoroethyl)butanamide
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Formula
C25H25F6N3O
Molecular Weight
497.483
Canonical SMILES
CC[C@H](NCC1CC(c2c(-c3ccc(F)cc3)[nH]c3c(F)cc(F)cc23)C1)C(=O)NCC(F)(F)F
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InChI
InChI=1S/C25H25F6N3O/c1-2-20(24(35)33-12-25(29,30)31)32-11-13-7-15(8-13)21-18-9-17(27)10-19(28)23(18)34-22(21)14-3-5-16(26)6-4-14/h3-6,9-10,13,15,20,32,34H,2,7-8,11-12H2,1H3,(H,33,35)/t13?,15?,20-/m0/s1
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InChIKey
JWTONGMCWOLVHN-IELXDLANSA-N
Physicochemical Property
logP
5.7925
Rotatable Bonds
8
Heavy Atom Count
35
Polar Areas
56.92
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
2
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT07126, Apolipoprotein L1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000058 T-REx-293 Homo sapiens (Human)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS