General Information of the Compound
Compound ID
CP0950895
Compound Name
MOTILIN_055
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Structure
Formula
C25H26ClFN4O2
Molecular Weight
468.96
Canonical SMILES
C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)cc2Cl)CCN1
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InChI
InChI=1S/C25H26ClFN4O2/c1-17-15-31(12-11-28-17)16-19-3-7-21(13-23(19)26)30(2)25(32)18-4-10-24(29-14-18)33-22-8-5-20(27)6-9-22/h3-10,13-14,17,28H,11-12,15-16H2,1-2H3/t17-/m0/s1
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InChIKey
FXBMHOHXPVPWSS-KRWDZBQOSA-N
Physicochemical Property
logP
4.7367
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
57.7
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 23728875
SID: 47213639
ChEMBL ID
CHEMBL2364317
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01121, Motilin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 0.3162 nM
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