General Information of the Compound
Compound ID
CP0949310
Compound Name
1-amino-5-[4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxamido]-3-oxa-pentane
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Structure
Formula
C18H26N4O4S
Molecular Weight
394.497
Canonical SMILES
CC1=C(C(=O)NCCOCCOCCN)C(c2cccc(O)c2)NC(=S)N1
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InChI
InChI=1S/C18H26N4O4S/c1-12-15(17(24)20-6-8-26-10-9-25-7-5-19)16(22-18(27)21-12)13-3-2-4-14(23)11-13/h2-4,11,16,23H,5-10,19H2,1H3,(H,20,24)(H2,21,22,27)
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InChIKey
IPQUUOBGQFXZQP-UHFFFAOYSA-N
Physicochemical Property
logP
0.2931
Rotatable Bonds
10
Heavy Atom Count
27
Polar Areas
117.87
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
6
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44435341
ChEMBL ID
CHEMBL240689
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01160, Kinesin-like protein KIF11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa Homo sapiens (Human)  1
1
IC50 = 3900 nM
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