General Information of the Compound
Compound ID
CP0946434
Compound Name
3-(1-(hydroxyimino)-3,3-dimethyl-2,3-dihydro-1H-inden-5-yl)benzonitrile
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Structure
Formula
C18H16N2O
Molecular Weight
276.339
Canonical SMILES
CC1(C)C/C(=N\O)c2ccc(-c3cccc(C#N)c3)cc21
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InChI
InChI=1S/C18H16N2O/c1-18(2)10-17(20-21)15-7-6-14(9-16(15)18)13-5-3-4-12(8-13)11-19/h3-9,21H,10H2,1-2H3/b20-17+
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InChIKey
JIKHATGBFZSJGW-LVZFUZTISA-N
Physicochemical Property
logP
4.08488
Rotatable Bonds
1
Heavy Atom Count
21
Polar Areas
56.38
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45483823
ChEMBL ID
CHEMBL565906
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 317 nM
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