General Information of the Compound
Compound ID
CP0945080
Compound Name
3-(3,5-Bis-trifluoromethyl-benzyl)-5-(1H-indol-3-ylmethyl)-2,4-dioxo-imidazolidine-1-carboxylic acid methylamide
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Structure
Formula
C23H18F6N4O3
Molecular Weight
512.41
Canonical SMILES
CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12
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InChI
InChI=1S/C23H18F6N4O3/c1-30-20(35)33-18(8-13-10-31-17-5-3-2-4-16(13)17)19(34)32(21(33)36)11-12-6-14(22(24,25)26)9-15(7-12)23(27,28)29/h2-7,9-10,18,31H,8,11H2,1H3,(H,30,35)
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InChIKey
SOVVORMDBAETNG-UHFFFAOYSA-N
Physicochemical Property
logP
4.9204
Rotatable Bonds
4
Heavy Atom Count
36
Polar Areas
85.51
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10052114
SID: 15035672
ChEMBL ID
CHEMBL425848
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 63 nM
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