General Information of the Compound
Compound ID
CP0944161
Compound Name
2-Methyl-8-(pyridin-3-ylsulfonyl)-2,3,4,5-tetrahydro-1Hpyrido[4,3-b]indole hydrochloride
    Show/Hide
Structure
Formula
C17H18ClN3O2S
Molecular Weight
363.87
Canonical SMILES
CN1CCc2[nH]c3ccc(S(=O)(=O)c4cccnc4)cc3c2C1.Cl
    Show/Hide
InChI
InChI=1S/C17H17N3O2S.ClH/c1-20-8-6-17-15(11-20)14-9-12(4-5-16(14)19-17)23(21,22)13-3-2-7-18-10-13;/h2-5,7,9-10,19H,6,8,11H2,1H3;1H
    Show/Hide
InChIKey
KQEKMJZCGRYCRQ-UHFFFAOYSA-N
Physicochemical Property
logP
2.8054
Rotatable Bonds
2
Heavy Atom Count
24
Polar Areas
66.06
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 45113654
SID: 92302704
ChEMBL ID
CHEMBL1095273
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS