General Information of the Compound
Compound ID
CP0943821
Compound Name
[3-(2-{2-[3-(2-Furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamino)propoxy]ethoxy}ethoxy)propyl]carbamic acid tert-butyl ester
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Structure
Formula
C26H38N8O6
Molecular Weight
558.64
Canonical SMILES
Cn1cc2c(nc(NCCCOCCOCCOCCCNC(=O)OC(C)(C)C)n3nc(-c4ccco4)nc23)n1
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InChI
InChI=1S/C26H38N8O6/c1-26(2,3)40-25(35)28-10-7-12-37-15-17-38-16-14-36-11-6-9-27-24-30-21-19(18-33(4)31-21)23-29-22(32-34(23)24)20-8-5-13-39-20/h5,8,13,18H,6-7,9-12,14-17H2,1-4H3,(H,28,35)(H,27,30,31)
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InChIKey
ZYQJMXBLKSAHAS-UHFFFAOYSA-N
Physicochemical Property
logP
3.0376
Rotatable Bonds
16
Heavy Atom Count
40
Polar Areas
152.09
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
13
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155534188
ChEMBL ID
CHEMBL4469798
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 8480 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 674 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 264 nM
   TI
   LI
   LO
   TS