General Information of the Compound
Compound ID
CP0935322
Compound Name
N'-[3-(3-Chlorophenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl]-N,N-dimethylethane-1,2-diamine dihydrochloride
    Show/Hide
Structure
Formula
C18H22Cl4N6O2S2
Molecular Weight
560.36
Canonical SMILES
CN(C)CCN(C)c1nc2c(S(=O)(=O)c3cccc(Cl)c3)nnn2c2ccsc12.Cl.Cl.Cl
    Show/Hide
InChI
InChI=1S/C18H19ClN6O2S2.3ClH/c1-23(2)8-9-24(3)16-15-14(7-10-28-15)25-17(20-16)18(21-22-25)29(26,27)13-6-4-5-12(19)11-13;;;/h4-7,10-11H,8-9H2,1-3H3;3*1H
    Show/Hide
InChIKey
SPFASSKNTNFMHG-UHFFFAOYSA-N
Physicochemical Property
logP
4.0884
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
83.7
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 90664684
ChEMBL ID
CHEMBL3216262
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 780 nM
   TI
   LI
   LO
   TS