General Information of the Compound
Compound ID
CP0932686
Compound Name
5-benzyl-3-{2-(3-chlorophenyl)-4-[3-oxospiro[2,3-dihydro-1H-indene-1,4'-(hexahydropyridine)]-1-yl]butyl}-(5R)-tetrahydro-1H-2,4-imidazoledione
    Show/Hide
Structure
Formula
C33H34ClN3O3
Molecular Weight
556.106
Canonical SMILES
O=C1CC2(CCN(CCC(CN3C(=O)N[C@H](Cc4ccccc4)C3=O)c3cccc(Cl)c3)CC2)c2ccccc21
    Show/Hide
InChI
InChI=1S/C33H34ClN3O3/c34-26-10-6-9-24(20-26)25(22-37-31(39)29(35-32(37)40)19-23-7-2-1-3-8-23)13-16-36-17-14-33(15-18-36)21-30(38)27-11-4-5-12-28(27)33/h1-12,20,25,29H,13-19,21-22H2,(H,35,40)/t25?,29-/m1/s1
    Show/Hide
InChIKey
VVPDJLRPPVILJY-SNSSHHSLSA-N
Physicochemical Property
logP
5.597
Rotatable Bonds
8
Heavy Atom Count
40
Polar Areas
69.72
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 489324
ChEMBL ID
CHEMBL319697
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS