General Information of the Compound
Compound ID
CP0932400
Compound Name
1-(4-Methylbenzenesulfonyl)-4-(piperazin-1-ylmethyl)-1H-indole dihydrochloride
    Show/Hide
Structure
Formula
C20H25Cl2N3O2S
Molecular Weight
442.412
Canonical SMILES
Cc1ccc(S(=O)(=O)n2ccc3c(CN4CCNCC4)cccc32)cc1.Cl.Cl
    Show/Hide
InChI
InChI=1S/C20H23N3O2S.2ClH/c1-16-5-7-18(8-6-16)26(24,25)23-12-9-19-17(3-2-4-20(19)23)15-22-13-10-21-11-14-22;;/h2-9,12,21H,10-11,13-15H2,1H3;2*1H
    Show/Hide
InChIKey
SJECABFDQOGBEG-UHFFFAOYSA-N
Physicochemical Property
logP
3.43552
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
54.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 24969960
SID: 56268113
ChEMBL ID
CHEMBL3216123
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 10.72 nM
   TI
   LI
   LO
   TS