General Information of the Compound
Compound ID
CP0930932
Compound Name
(4-{2-(4-Fluorophenyl)-2-[(thiophen-2-ylmethyl)amino]ethyl}piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
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Structure
Formula
C22H28FN3O2S
Molecular Weight
417.55
Canonical SMILES
O=C(C1CCCO1)N1CCN(CC(NCc2cccs2)c2ccc(F)cc2)CC1
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InChI
InChI=1S/C22H28FN3O2S/c23-18-7-5-17(6-8-18)20(24-15-19-3-2-14-29-19)16-25-9-11-26(12-10-25)22(27)21-4-1-13-28-21/h2-3,5-8,14,20-21,24H,1,4,9-13,15-16H2
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InChIKey
NYVDYEQXJKXCIV-UHFFFAOYSA-N
Physicochemical Property
logP
3.0413
Rotatable Bonds
7
Heavy Atom Count
29
Polar Areas
44.81
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 51000744
SID: 117683690
ChEMBL ID
CHEMBL4519124
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06765, Hepcidin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000031 MDCK Canis lupus familiaris (Dog)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS