General Information of the Compound
Compound ID
CP0921718
Compound Name
N-[4-chloro-2-hydroxy-3-(4-piperidinylsulfo-nyl)phenyl]-N'-[2-(phenyloxy)phenyl]urea
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Structure
Formula
C24H24ClN3O5S
Molecular Weight
501.992
Canonical SMILES
O=C(Nc1ccccc1Oc1ccccc1)Nc1ccc(Cl)c(S(=O)(=O)C2CCNCC2)c1O
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InChI
InChI=1S/C24H24ClN3O5S/c25-18-10-11-20(22(29)23(18)34(31,32)17-12-14-26-15-13-17)28-24(30)27-19-8-4-5-9-21(19)33-16-6-2-1-3-7-16/h1-11,17,26,29H,12-15H2,(H2,27,28,30)
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InChIKey
VSFXNIKJSPGYDK-UHFFFAOYSA-N
Physicochemical Property
logP
5.0076
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
116.76
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 50996777
SID: 117642961
ChEMBL ID
CHEMBL3948111
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01304, C-X-C chemokine receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 < 30000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01013, C-X-C chemokine receptor type 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 < 30000 nM
   TI
   LI
   LO
   TS