General Information of the Compound
Compound ID
CP0920952
Compound Name
(R)-(2-((1H-indol-3-yl)methyl)-4-(3-(2-morpholinoethoxyimino)butyl)piperazin-1-yl)(3,5-bis(trifluoromethyl)phenyl)methanone
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Structure
Formula
C32H37F6N5O3
Molecular Weight
653.668
Canonical SMILES
C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1
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InChI
InChI=1S/C32H37F6N5O3/c1-22(40-46-15-12-41-10-13-45-14-11-41)6-7-42-8-9-43(27(21-42)18-24-20-39-29-5-3-2-4-28(24)29)30(44)23-16-25(31(33,34)35)19-26(17-23)32(36,37)38/h2-5,16-17,19-20,27,39H,6-15,18,21H2,1H3/b40-22-/t27-/m1/s1
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InChIKey
JCKNROOTXBQYOS-YXHYVMOGSA-N
Physicochemical Property
logP
5.6894
Rotatable Bonds
10
Heavy Atom Count
46
Polar Areas
73.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44408025
ChEMBL ID
CHEMBL204979
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Kd = 1.259 nM
   TI
   LI
   LO
   TS
2
Ki = 0.3981 nM
   TI
   LI
   LO
   TS