General Information of the Compound
Compound ID
CP0919404
Compound Name
4-{[(3S)-1-Butyl-3-(cyclohexylmethyl)-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl]methyl}-N-phenylbenzamide hydrochloride
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Structure
Formula
C33H45ClN4O3
Molecular Weight
581.201
Canonical SMILES
CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)Nc3ccccc3)cc1)CC2.Cl
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InChI
InChI=1S/C33H44N4O3.ClH/c1-2-3-20-37-31(39)29(23-25-10-6-4-7-11-25)35-32(40)33(37)18-21-36(22-19-33)24-26-14-16-27(17-15-26)30(38)34-28-12-8-5-9-13-28;/h5,8-9,12-17,25,29H,2-4,6-7,10-11,18-24H2,1H3,(H,34,38)(H,35,40);1H/t29-;/m0./s1
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InChIKey
WJNBDBJRHIBKDQ-JMAPEOGHSA-N
Physicochemical Property
logP
5.7928
Rotatable Bonds
9
Heavy Atom Count
41
Polar Areas
81.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49799706
ChEMBL ID
CHEMBL1170873
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 57 nM
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