General Information of the Compound
Compound ID
CP0918488
Compound Name
rac-N-(biphenyl-2-yl)-2-(naphthalen-1-yl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide
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Structure
Formula
C29H24N4O3
Molecular Weight
476.536
Canonical SMILES
O=C(Nc1ccccc1-c1ccccc1)N1CCN2C(=O)N(c3cccc4ccccc34)C(=O)C2C1
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InChI
InChI=1S/C29H24N4O3/c34-27-26-19-31(28(35)30-24-15-7-6-13-22(24)20-9-2-1-3-10-20)17-18-32(26)29(36)33(27)25-16-8-12-21-11-4-5-14-23(21)25/h1-16,26H,17-19H2,(H,30,35)
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InChIKey
KHLYDKCXTXXEAT-UHFFFAOYSA-N
Physicochemical Property
logP
5.1917
Rotatable Bonds
3
Heavy Atom Count
36
Polar Areas
72.96
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56676765
ChEMBL ID
CHEMBL1808443
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  1
1
IC50 > 2500 nM
   TI
   LI
   LO
   TS