General Information of the Compound
Compound ID
CP0915529
Compound Name
rac-N-(2-chloro-4-cyano-6-methylphenyl)-1,3-dioxo-2-((1S,2R)-2-phenylcyclopropyl)hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide
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Structure
Formula
C24H22ClN5O3
Molecular Weight
463.925
Canonical SMILES
Cc1cc(C#N)cc(Cl)c1NC(=O)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1
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InChI
InChI=1S/C24H22ClN5O3/c1-14-9-15(12-26)10-18(25)21(14)27-23(32)28-7-8-29-20(13-28)22(31)30(24(29)33)19-11-17(19)16-5-3-2-4-6-16/h2-6,9-10,17,19-20H,7-8,11,13H2,1H3,(H,27,32)/t17-,19+,20?/m1/s1
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InChIKey
FPOUQJTYZRLOBK-MVGXFMOLSA-N
Physicochemical Property
logP
3.5565
Rotatable Bonds
3
Heavy Atom Count
33
Polar Areas
96.75
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56659616
ChEMBL ID
CHEMBL1808458
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 84 nM
   TI
   LI
   LO
   TS
CL000426 Shh Light II Mus musculus (Mouse)  1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS