General Information of the Compound
Compound ID
CP0908893
Compound Name
SID144192239
    Show/Hide
Structure
Formula
C28H23F2N3O3
Molecular Weight
487.506
Canonical SMILES
O=C(Nc1ccc(F)cc1)N1CC(=O)N2[C@@H](CO)[C@@H](c3ccc(C#Cc4ccc(F)cc4)cc3)[C@@H]2C1
    Show/Hide
InChI
InChI=1S/C28H23F2N3O3/c29-21-9-5-19(6-10-21)2-1-18-3-7-20(8-4-18)27-24-15-32(16-26(35)33(24)25(27)17-34)28(36)31-23-13-11-22(30)12-14-23/h3-14,24-25,27,34H,15-17H2,(H,31,36)/t24-,25-,27-/m0/s1
    Show/Hide
InChIKey
RHVAAZYGDMPMSB-KLJDGLGGSA-N
Physicochemical Property
logP
3.5676
Rotatable Bonds
3
Heavy Atom Count
36
Polar Areas
72.88
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 60186490
ChEMBL ID
CHEMBL2358020
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06124, Paired box protein Pax-8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000097 RMG-I Homo sapiens (Human)  1
1
AC50 = 10390 nM
   TI
   LI
   LO
   TS