General Information of the Compound
Compound ID
CP0908331
Compound Name
8-(Benzo[b]thiophen-3-yl)-2-(pyridin-3-ylmethyl)-2,3,4,5-tetrahydro-1H-benzo[c]azepine
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Structure
Formula
C24H22N2S
Molecular Weight
370.521
Canonical SMILES
c1cncc(CN2CCCc3ccc(-c4csc5ccccc45)cc3C2)c1
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InChI
InChI=1S/C24H22N2S/c1-2-8-24-22(7-1)23(17-27-24)20-10-9-19-6-4-12-26(16-21(19)13-20)15-18-5-3-11-25-14-18/h1-3,5,7-11,13-14,17H,4,6,12,15-16H2
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InChIKey
OUIYQRYTMPYCJH-UHFFFAOYSA-N
Physicochemical Property
logP
5.9117
Rotatable Bonds
3
Heavy Atom Count
27
Polar Areas
16.13
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122180290
ChEMBL ID
CHEMBL3586354
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00948, Prostaglandin E2 receptor EP2 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000516 ECV-304 Homo sapiens (Human)  2
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
2
IC50 > 30000 nM
   TI
   LI
   LO
   TS