General Information of the Compound
Compound ID
CP0904893
Compound Name
[(R)-4-(3,5-bis-trifluoromethyl-benzoyl)-3-(1H-indol-3-ylmethyl)-piperazin-1-yl]-acetaldehyde O-(3-morpholin-4-yl-propyl)-oxime
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Structure
Formula
C31H35F6N5O3
Molecular Weight
639.641
Canonical SMILES
O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12
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InChI
InChI=1S/C31H35F6N5O3/c32-30(33,34)24-16-22(17-25(19-24)31(35,36)37)29(43)42-10-9-41(8-6-39-45-13-3-7-40-11-14-44-15-12-40)21-26(42)18-23-20-38-28-5-2-1-4-27(23)28/h1-2,4-6,16-17,19-20,26,38H,3,7-15,18,21H2/b39-6-/t26-/m1/s1
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InChIKey
JIWGLAUBRTXBNX-XKKPCFNCSA-N
Physicochemical Property
logP
5.2993
Rotatable Bonds
10
Heavy Atom Count
45
Polar Areas
73.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44407998
ChEMBL ID
CHEMBL204262
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Kd = 0.631 nM
   TI
   LI
   LO
   TS
2
Ki = 1.259 nM
   TI
   LI
   LO
   TS